دورية أكاديمية
Investigation of the relationship between interferon-gamma receptor 1-56C/T gene polymorphism and genetic susceptibility to lung sarcoidosis: A cross-sectional study
| العنوان: | Investigation of the relationship between interferon-gamma receptor 1-56C/T gene polymorphism and genetic susceptibility to lung sarcoidosis: A cross-sectional study |
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| المؤلفون: | Kavas, M., Çobankara, V., Boğa, S., Kaymaz, S., Demiray, A., Karasu, U. |
| بيانات النشر: | Turkish League Against Rheumatism (TLAR) |
| سنة النشر: | 2023 |
| المجموعة: | Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi |
| مصطلحات موضوعية: | polymorphism, Interferon-gamma receptor 1, sarcoidosis, angiotensin converting enzyme 2, gamma interferon receptor 1, adult, aged, Article, controlled study, cross-sectional study, DNA extraction, female, gene, gene amplification, gene frequency, genetic polymorphism, genetic susceptibility, genetic variation, genotype, genotyping, Hardy Weinberg equilibrium, human, IFNGR1-56C/T, immunosuppressive treatment, lung sarcoidosis, major clinical study, male, normal human, radiography, real time polymerase chain reaction |
| الوصف: | Objectives: This study aims to investigate the relationship between the interferon-gamma receptor 1 (IFNGR1) polymorphism and susceptibility to lung sarcoidosis. Patients and methods: The study included a total of 55 patients (13 males, 42 females; mean age: 46.5±9.1 years; range, 22 to 66 years) with lung sarcoidosis and 28 healthy controls (6 males, 22 females; mean age: 43.9±5.9 years; range 22 to 60 years) selected from the Turkish population. The polymerase chain reaction was used for genotyping of participants to determine single-nucleotide polymorphisms. Hardy-Weinberg equilibrium, which is considered an important tool for detecting genotyping errors, was tested. Allele and genotype frequencies of patients and controls were compared using logistic regression analysis. Results: The analyses showed no correlation between the tested IFNGR1 single-nucleotide polymorphism (rs2234711) and lung sarcoidosis (p>0.05). The categorization analysis according to the clinical features, laboratory, and radiographic characteristics showed no correlation between the tested polymorphism of IFNGR1 (rs2234711) and these characteristics (p>0.05). Conclusion: The results of the study showed that the tested gene polymorphism (rs2234711) of IFNGR1 was not associated with lung sarcoidosis. More comprehensive studies are needed to verify our results. © 2023 Turkish League Against Rheumatism. All rights reserved. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2618-6500 |
| العلاقة: | Archives of Rheumatology; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/52827Test; https://doi.org/10.46497/ArchRheumatol.2022.9239Test; 38; 001; 008; 2-s2.0-85150239875 |
| DOI: | 10.46497/ArchRheumatol.2022.9239 |
| الإتاحة: | https://doi.org/10.46497/ArchRheumatol.2022.9239Test https://hdl.handle.net/11499/52827Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.16A2A142 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 26186500 |
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| DOI: | 10.46497/ArchRheumatol.2022.9239 |