دورية أكاديمية
The effect of iloprost and n-acetylcysteine on skeletal muscle injury in an acute aortic ischemia-reperfusion model: An experimental study
| العنوان: | The effect of iloprost and n-acetylcysteine on skeletal muscle injury in an acute aortic ischemia-reperfusion model: An experimental study |
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| المؤلفون: | Tiryakioglu, O., Erkoc, K., Tunerir, B., Altin, H.F., GüneÅŸ, Tevfik, Uysal, O., Aydin, S. |
| بيانات النشر: | Hindawi Publishing Corporation |
| سنة النشر: | 2015 |
| المجموعة: | Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi |
| مصطلحات موضوعية: | acetylcysteine, 2,2' azinobis(3 ethylbenzothiazoline 6 sulfonic acid), creatine kinase, iloprost, lactate dehydrogenase, reactive oxygen metabolite, abdominal aorta, animal experiment, animal model, animal tissue, Article, cell infiltration, cell swelling, controlled study, experimental study, gastrocnemius muscle, heart muscle ischemia, histopathology, loading drug dose, macrophage, male, monocyte, nonhuman, rat, reperfusion injury, animal, drug effects, human, injuries, pathology |
| الوصف: | Objective. The objective of this study was to examine the effects of iloprost and N-acetylcysteine (NAC) on ischemia-reperfusion (IR) injuries to the gastrocnemius muscle, following the occlusion-reperfusion period in the abdominal aorta of rats. Materials and Methods. Forty male Sprague-Dawley rats were randomly divided into four equal groups. Group 1: control group. Group 2 (IR): aorta was occluded. The clamp was removed after 1 hour of ischemia. Blood samples and muscle tissue specimens were collected following a 2-hour reperfusion period. Group 3 (IR + iloprost): during a 1-hour ischemia period, iloprost infusion was initiated from the jugular catheter. During a 2-hour reperfusion period, the iloprost infusion continued. Group 4 (IR + NAC): similar to the iloprost group. Findings. The mean total oxidant status, CK, and LDH levels were highest in Group 2 and lowest in Group 1. The levels of these parameters in Group 3 and Group 4 were lower compared to Group 2 and higher compared to Group 1 (P 0.05). The histopathological examination showed that Group 3 and Group 4, compared to Group 2, had preserved appearance with respect to hemorrhage, necrosis, loss of nuclei, infiltration, and similar parameters. Conclusion. Iloprost and NAC are effective against ischemia-reperfusion injury and decrease ischemia-related tissue injury. © 2015 Osman Tiryakioglu et al. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2314-6133 |
| العلاقة: | BioMed Research International; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/10490Test; https://doi.org/10.1155/2015/453748Test; 2015; 2-s2.0-84925326247; WOS:000351371300001 |
| DOI: | 10.1155/2015/453748 |
| الإتاحة: | https://doi.org/10.1155/2015/453748Test https://hdl.handle.net/11499/10490Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.3DA17A05 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23146133 |
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| DOI: | 10.1155/2015/453748 |