دورية أكاديمية
In inflammatory myopathies, dropped head/bent spine syndrome is associated with scleromyositis: an international case-control study
| العنوان: | In inflammatory myopathies, dropped head/bent spine syndrome is associated with scleromyositis: an international case-control study |
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| المؤلفون: | Pijnenburg, Luc, Giannini, Margherita, Bouchard-Marmen, Maude, Arnaud, Laurent, Barsotti, Simone, Bellando-Randone, Silvia, Bernardi, Livio, Bini, Paola, Blagojevic, Jelena, Codullo, Veronica, Couderc, Marion, De Moreuil, Claire, Dernis, Emanuelle, Diamanti, Luca, Dubost, Jean Jacques, Duval, Fanny, Emmi, Giacomo, Galempoix, Jean-Marc, Geny, Bernard, Gottenberg, Jacques-Eric, Groza, Monica, Guffroy, Aurelien, Guichard, Isabelle, Guilpain, Philippe, Hervier, Baptiste, Hudson, Marie, Iaccarino, Luca, Iannone, Florenzo, Lebrun, Delphine, Marchioni, Enrico, Mariampillai, Kuberaka, Maurier, Francois, Mosca, Marta, Nadaj-Pakleza, Aleksandra, Nannini, Carlotta, Piot, Jean-Maxime, Prieto-González, Sergio, Poursac, Nicolas, Rouanet, Eglantine, Sellam, Jérémie, Selva-O'Callaghan, Albert, Séverac, François, Sibilia, Jean, Sole, Guilhem, Soulages, Antoine, Terrier, Benjamin, Tournadre, Anne, Troyanov, Yves, Vernier, Nathalie, Vesperini, Veronique, Viallard, Jean-François, Ziane, Rahima, Cavagna, Lorenzo, Meyer, Alain |
| المساهمون: | Pijnenburg, Luc, Giannini, Margherita, Bouchard-Marmen, Maude, Arnaud, Laurent, Barsotti, Simone, Bellando-Randone, Silvia, Bernardi, Livio, Bini, Paola, Blagojevic, Jelena, Codullo, Veronica, Couderc, Marion, De Moreuil, Claire, Dernis, Emanuelle, Diamanti, Luca, Dubost, Jean Jacque, Duval, Fanny, Emmi, Giacomo, Galempoix, Jean-Marc, Geny, Bernard, Gottenberg, Jacques-Eric, Groza, Monica, Guffroy, Aurelien, Guichard, Isabelle, Guilpain, Philippe, Hervier, Baptiste, Hudson, Marie, Iaccarino, Luca, Iannone, Florenzo, Lebrun, Delphine, Marchioni, Enrico, Mariampillai, Kuberaka, Maurier, Francoi, Mosca, Marta, Nadaj-Pakleza, Aleksandra, Nannini, Carlotta, Piot, Jean-Maxime, Prieto-González, Sergio, Poursac, Nicola, Rouanet, Eglantine, Sellam, Jérémie, Selva-O'Callaghan, Albert, Séverac, Françoi, Sibilia, Jean, Sole, Guilhem, Soulages, Antoine, Terrier, Benjamin, Tournadre, Anne, Troyanov, Yve, Vernier, Nathalie, Vesperini, Veronique, Viallard, Jean-Françoi, Ziane, Rahima, Cavagna, Lorenzo, Meyer, Alain |
| بيانات النشر: | BMJ PUBLISHING GROUP |
| سنة النشر: | 2023 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: | dermatomyositi, polymyositi, systemic sclerosis |
| الوصف: | Background Some myopathies can lead to dropped head or bent spine syndrome (DH/BS). The significance of this symptom has not been studied in inflammatory myopathies (IM).Objectives To assess the significance of DH/BS in patients with IM.Methods Practitioners from five IM networks were invited to report patients with IM suffering from DH/BS (without other known cause than IM). IM patients without DH/BS, randomly selected in each participating centre, were included as controls at a ratio of 2 to 1.Results 49 DH/BS-IM patients (DH: 57.1%, BS: 42.9%) were compared with 98 control-IM patients. DH/BS-IM patients were older (65 years vs 53 years, p<0.0001) and the diagnosis of IM was delayed (6 months vs 3 months, p=0.009). Weakness prevailing in the upper limbs (42.9% vs 15.3%), dysphagia (57.1% vs 25.5%), muscle atrophy (65.3% vs 34.7%), weight loss (61.2% vs 23.5%) and loss of the ability to walk (24.5% vs 5.1%) were hallmarks of DH/BS-IM (p <= 0.0005), for which the patients more frequently received intravenous immunoglobulins (65.3% vs 34.7%, p=0.0004). Moreover, DH/BS-IM patients frequently featured signs and/or complications of systemic sclerosis ( SSc), fulfilling the American College of Rheumatology/European Alliance of Associations for Rheumatology criteria for this disease in 40.8% of the cases (vs 5.1%, p<0.0001). Distribution of the myopathy, its severity and its association with SSc were independently associated with DH/BS ( p<0.05). Mortality was higher in the DH/BS-IM patients and loss of walking ability was independently associated with survival (p<0.05).Conclusion In IM patients, DH/BS is a marker of severity and is associated with SSc (scleromyositis). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/37666644; info:eu-repo/semantics/altIdentifier/wos/WOS:001066158300002; volume:9; issue:3; journal:RMD OPEN; https://hdl.handle.net/11577/3508909Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85169848951 |
| DOI: | 10.1136/rmdopen-2023-003081 |
| الإتاحة: | https://doi.org/10.1136/rmdopen-2023-003081Test https://hdl.handle.net/11577/3508909Test |
| رقم الانضمام: | edsbas.E06783C8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/rmdopen-2023-003081 |
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