دورية أكاديمية
AA-amyloidosis in cats (Felis catus) housed in shelters
| العنوان: | AA-amyloidosis in cats (Felis catus) housed in shelters |
|---|---|
| المؤلفون: | Filippo Ferri, Silvia Ferro, Federico Porporato, Carolina Callegari, Chiara Guglielmetti, Maria Mazza, Marta Ferrero, Chiara Crinò, Enrico Gallo, Michele Drigo, Luigi Michele Coppola, Gabriele Gerardi, Tim Paul Schulte, Stefano Ricagno, Monique Vogel, Federico Storni, Martin F. Bachmann, Anne-Cathrine Vogt, Serena Caminito, Giulia Mazzini, Francesca Lavatelli, Giovanni Palladini, Giampaolo Merlini, Eric Zini |
| المساهمون: | Ferri, Filippo, Ferro, Silvia, Porporato, Federico, Callegari, Carolina, Guglielmetti, Chiara, Mazza, Maria, Ferrero, Marta, Crinò, Chiara, Gallo, Enrico, Drigo, Michele, Coppola, LUIGI MICHELE, Gerardi, Gabriele, Paul Schulte, Tim, Ricagno, Stefano, Vogel, Monique, Storni, Federico, Bachmann, Martin F., Vogt, Anne-Cathrine, Caminito, Serena, Mazzini, Giulia, Lavatelli, Francesca, Palladini, Giovanni, Merlini, Giampaolo, Zini, Eric |
| بيانات النشر: | Public Library of Science |
| سنة النشر: | 2023 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| الوصف: | Systemic AA-amyloidosis is a protein-misfolding disease characterized by fibril deposition of serum amyloid-A protein (SAA) in several organs in humans and many animal species. Fibril deposits originate from abnormally high serum levels of SAA during chronic inflammation. A high prevalence of AA-amyloidosis has been reported in captive cheetahs and a horizontal transmission has been proposed. In domestic cats, AA-amyloidosis has been mainly described in predisposed breeds but only rarely reported in domestic short-hair cats. Aims of the study were to determine AA-amyloidosis prevalence in dead shelter cats. Liver, kidney, spleen and bile were collected at death in cats from 3 shelters. AA-amyloidosis was scored. Shedding of amyloid fibrils was investigated with western blot in bile and scored. Descriptive statistics were calculated. In the three shelters investigated, prevalence of AA-amyloidosis was 57.1% (16/28 cats), 73.0% (19/26) and 52.0% (13/25), respectively. In 72.9% of cats (35 in total) three organs were affected concurrently. Histopathology and immunofluorescence of post-mortem extracted deposits identified SAA as the major protein source. The duration of stay in the shelters was positively associated with a histological score of AA-amyloidosis (B = 0.026, CI95% = 0.007-0.046; p = 0.010). AA-amyloidosis was very frequent in shelter cats. Presence of SAA fragments in bile secretions raises the possibility of fecal-oral transmission of the disease. In conclusion, AA-amyloidosis was very frequent in shelter cats and those staying longer had more deposits. The cat may represent a natural model of AA-amyloidosis. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/36989207; info:eu-repo/semantics/altIdentifier/wos/WOS:000988260400001; volume:18; issue:3; numberofpages:14; journal:PLOS ONE; https://hdl.handle.net/11577/3473623Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85151312574; https://doi.org/10.1371/journal.pone.0281822Test |
| DOI: | 10.1371/journal.pone.0281822 |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0281822Test https://hdl.handle.net/11577/3473623Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.97A5C7DD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0281822 |
|---|