دورية أكاديمية
CSF Findings in Relation to Clinical Characteristics, Subtype, and Disease Course in Patients With Guillain-Barré Syndrome
| العنوان: | CSF Findings in Relation to Clinical Characteristics, Subtype, and Disease Course in Patients With Guillain-Barré Syndrome |
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| المؤلفون: | Al-Hakem, Helle, Doets, Alex Y., Stino, Amro Maher, Zivkovic, Sasha A., Andersen, Henning, Willison, Hugh J., Cornblath, David R., Gorson, Kenneth C., Islam, Zhahirul, Mohammad, Quazi Deen, Sindrup, Søren Hein, Kusunoki, Susumu, Davidson, Amy, Casasnovas, Carlos, Bateman, Kathleen, Miller, James A. L., van den Berg, Bianca, Verboon, Christine, Roodbol, Joyce, Leonhard, Sonja E., Arends, Samuel, Luijten, Linda W. G., Benedetti, Luana, Kuwabara, Satoshi, Van den Bergh, Peter, Monges, Soledad, Marfia, Girolama A., Shahrizaila, Nortina, Galassi, Giuliana, Pereon, Yann, Bürmann, Jan, Kuitwaard, Krista, Kleyweg, Ruud P., Marchesoni, Cintia, Sedano Tous, María J., Querol, Luis, Martín-Aguilar, Lorena, Wang, Yuzhong, Nobile-Orazio, Eduardo, Rinaldi, Simon, Schenone, Angelo, Pardo, Julio, Vermeij, Frederique H., Waheed, Waqar, Lehmann, Helmar C., Granit, Volkan, Stein, Beth, Cavaletti, Guido, Gutiérrez-Gutiérrez, Gerardo, Barroso, Fabio A., Visser, Leo H., Katzberg, Hans D., Dardiotis, Efthimios, Attarian, Shahram, van der Kooi, Anneke J., Eftimov, Filip, Wirtz, Paul W., Samijn, Johnny P. A., Gilhuis, H. Jacobus, Hadden, Robert D. M., Holt, James K. L., Sheikh, Kazim A., Kolb, Noah, Karafiath, Summer, Vytopil, Michal, Antonini, Giovanni, Feasby, Thomas E., Faber, Catharina, Kramers, Hans, Busby, Mark, Roberts, Rhys C., Silvestri, Nicholas J., Fazio, Raffaella, van Dijk, Gert W., Garssen, Marcel P. J., Verschuuren, Jan, Harbo, Thomas, Jacobs, Bart C., Hughes, R. A. C., Hartung, H. P., de Koning, L. C., Mandarakas, M., van Woerkom, M., Reisin, R. C., Reddel, S. W., Hsieh, S. T., Addington, J. M., Ajroud-Driss, S., Alessandro, L., Badrising, U. A., Balloy, G., Bella, I. R., Bertorini, T. E., Bhavaraju-Sanka, R., Bianco, M., Brannagan, T. H., Brennan, K., Briani, C., Butterworth, S., Chao, C. C., Chen, S., Claeys, K. G., Conti, M. E., Cosgrove, J. S., Dalakas, M. C., Derejko, M., Dimachkie, M. M., Echaniz-Laguna, A., Fokke, C., Fujioka, T., Fulgenzi, E. A., Sobrino, T. García, Gijsbers, C. J., Gilchrist, J. M., Goldstein, J. M., Goodfellow, J., Goyal, N. A., Grisanti, S., Gutmann, L., Htut, M., Jellema, K., Pascual, I. Jericó, Jimeno-Montero, M. C., Kaida, K., Kerkhoff, H., Khoshnoodi, M., Kiers, L., Kuwahara, M., Kwan, J. Y., Ladha, S. S., Lassen, L. Landschoff, Lawson, V., Pan, E. Lee, Lunn, M. P. T., Manji, H., Infante, C. Márquez, Hernandez, E. Martinez, Mataluni, G., Mattiazzi, M. G., McDermott, C. J., Meekins, G. D., Morís de la Tassa, G., Nascimbene, C., Nowak, R. J., Orizaola, P., Osei-Bonsu, M., Pardal, A., Pascual-Goñi, E., Pascuzzi, R. M., Prada, V., Pulley, M., Rojas-Marcos, I., Rudnicki, S. A., Sachs, G. M., Santoro, L., Savransky, A., Schwindling, L., Sekiguchi, Y., Sommer, C. L., Tan, C-Y, Tankisi, H., Twydell, P. T., van Damme, P., van der Ree, T., van Koningsveld, R., Varrato, J. D., Santamaria, V. Vélez, Walgaard, C., Yamagishi, Y., Zhang, L., MM, null, Zhou, L., null, null |
| المساهمون: | Al-Hakem, Helle, Doets, Alex Y., Stino, Amro Maher, Zivkovic, Sasha A., Andersen, Henning, Willison, Hugh J., Cornblath, David R., Gorson, Kenneth C., Islam, Zhahirul, Mohammad, Quazi Deen, Sindrup, Søren Hein, Kusunoki, Susumu, Davidson, Amy, Casasnovas, Carlo, Bateman, Kathleen, Miller, James A. L., van den Berg, Bianca, Verboon, Christine, Roodbol, Joyce, Leonhard, Sonja E., Arends, Samuel, Luijten, Linda W. G., Benedetti, Luana, Kuwabara, Satoshi, Van den Bergh, Peter, Monges, Soledad, Marfia, Girolama A., Shahrizaila, Nortina, Galassi, Giuliana, Pereon, Yann, Bürmann, Jan, Kuitwaard, Krista, Kleyweg, Ruud P., Marchesoni, Cintia, Sedano Tous, María J., Querol, Lui, Martín-Aguilar, Lorena, Wang, Yuzhong, Nobile-Orazio, Eduardo, Rinaldi, Simon, Schenone, Angelo, Pardo, Julio, Vermeij, Frederique H., Waheed, Waqar, Lehmann, Helmar C., Granit, Volkan, Stein, Beth, Cavaletti, Guido, Gutiérrez-Gutiérrez, Gerardo, Barroso, Fabio A., Visser, Leo H., Katzberg, Hans D., Dardiotis, Efthimio, Attarian, Shahram, van der Kooi, Anneke J., Eftimov, Filip, Wirtz, Paul W., Samijn, Johnny P. A., Gilhuis, H. Jacobu, Hadden, Robert D. M., Holt, James K. L., Sheikh, Kazim A., Kolb, Noah, Karafiath, Summer, Vytopil, Michal, Antonini, Giovanni, Feasby, Thomas E., Faber, Catharina, Kramers, Han, Busby, Mark, Roberts, Rhys C., Silvestri, Nicholas J., Fazio, Raffaella, van Dijk, Gert W., Garssen, Marcel P. J., Verschuuren, Jan, Harbo, Thoma, Jacobs, Bart C., Hughes, R. A. C., Hartung, H. P., de Koning, L. C., Mandarakas, M., van Woerkom, M., Reisin, R. C., Reddel, S. W., Hsieh, S. T., Addington, J. M., Ajroud-Driss, S., Alessandro, L., Badrising, U. A., Balloy, G., Bella, I. R., Bertorini, T. E., Bhavaraju-Sanka, R., Bianco, M., Brannagan, T. H., Brennan, K., Briani, C., Butterworth, S., Chao, C. C. |
| بيانات النشر: | LIPPINCOTT WILLIAMS & WILKINS |
| سنة النشر: | 2023 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| الوصف: | Background and ObjectivesTo investigate CSF findings in relation to clinical and electrodiagnostic subtypes, severity, and outcome of Guillain-Barre syndrome (GBS) based on 1,500 patients in the International GBS Outcome Study.MethodsAlbuminocytologic dissociation (ACD) was defined as an increased protein level (>0.45 g/L) in the absence of elevated white cell count (<50 cells/& mu;L). We excluded 124 (8%) patients because of other diagnoses, protocol violation, or insufficient data. The CSF was examined in 1,231 patients (89%).ResultsIn 846 (70%) patients, CSF examination showed ACD, which increased with time from weakness onset: & LE;4 days 57%, >4 days 84%. High CSF protein levels were associated with a demyelinating subtype, proximal or global muscle weakness, and a reduced likelihood of being able to run at week 2 (odds ratio [OR] 0.42, 95% CI 0.25-0.70; p = 0.001) and week 4 (OR 0.44, 95% CI 0.27-0.72; p = 0.001). Patients with the Miller Fisher syndrome, distal predominant weakness, and normal or equivocal nerve conduction studies were more likely to have lower CSF protein levels. CSF cell count was <5 cells/& mu;L in 1,005 patients (83%), 5-49 cells/& mu;L in 200 patients (16%), and & GE;50 cells/& mu;L in 13 patients (1%).DiscussionACD is a common finding in GBS, but normal protein levels do not exclude this diagnosis. High CSF protein level is associated with an early severe disease course and a demyelinating subtype. Elevated CSF cell count, rarely & GE;50 cells/& mu;L, is compatible with GBS after a thorough exclusion of alternative diagnoses.Classification of EvidenceThis study provides Class IV evidence that CSF ACD (defined by the Brighton Collaboration) is common in patients with GBS. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/37076309; info:eu-repo/semantics/altIdentifier/wos/WOS:001021280300017; volume:100; issue:23; journal:NEUROLOGY; https://hdl.handle.net/11577/3510428Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85162175839 |
| DOI: | 10.1212/wnl.0000000000207282 |
| الإتاحة: | https://doi.org/10.1212/wnl.0000000000207282Test https://hdl.handle.net/11577/3510428Test |
| رقم الانضمام: | edsbas.555A43D0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1212/wnl.0000000000207282 |
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