دورية أكاديمية
Sensorineural hearing loss and ischemic injury: Development of animal models to assess vascular and oxidative effects
| العنوان: | Sensorineural hearing loss and ischemic injury: Development of animal models to assess vascular and oxidative effects |
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| المؤلفون: | OLIVETTO, ELENA, SIMONI, EDI, GUARAN, VALERIA, ASTOLFI, LAURA, MARTINI, ALESSANDRO |
| المساهمون: | Olivetto, Elena, Simoni, Edi, Guaran, Valeria, Astolfi, Laura, Martini, Alessandro |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2015 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: | ABR, Bcl-2, Cyt-c, HIF-1α, IHC, JNK, MAPK, MYH-6, NF-200, NF-kB, OHC, PJNK, ROS, TF, TM, TSH, Sensory Systems |
| الوصف: | Hearing loss may be genetic, associated with aging or exposure to noise or ototoxic substances. Its aetiology can be attributed to vascular injury, trauma, tumours, infections or autoimmune response. All these factors could be related to alterations in cochlear microcirculation resulting in hypoxia, which in turn may damage cochlear hair cells and neurons, leading to deafness. Hypoxia could underlie the aetiology of deafness, but very few data about it are presently available. The aim of this work is to develop animal models of hypoxia and ischemia suitable for study of cochlear vascular damage, characterizing them by electrophysiology and gene/protein expression analyses. The effects of hypoxia in infarction were mimicked in rat by partial permanent occlusion of the left coronary artery, and those of ischemia in thrombosis by complete temporary carotid occlusion. In our models both hypoxia and ischemia caused a small but significant hearing loss, localized at the cochlear apex. A slight induction of the coagulation cascade and of oxidative stress pathways was detected as cell survival mechanism, and cell damages were found on the cuticular plate of outer hair cells only after carotid ischemia. Based on these data, the two developed models appear suitable for in vivo studies of cochlear vascular damage. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/25987500; info:eu-repo/semantics/altIdentifier/wos/WOS:000361251900007; volume:327; firstpage:58; lastpage:68; numberofpages:11; journal:HEARING RESEARCH; http://hdl.handle.net/11577/3173460Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84930638534; www.elsevier.com/locate/heares |
| DOI: | 10.1016/j.heares.2015.05.004 |
| الإتاحة: | https://doi.org/10.1016/j.heares.2015.05.004Test http://hdl.handle.net/11577/3173460Test |
| رقم الانضمام: | edsbas.398916BE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.heares.2015.05.004 |
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