دورية أكاديمية
Molecular surveillance of pandemic influenza A(H1N1) viruses circulating in Italy from May 2009 to February 2010: association between haemagglutinin mutations and clinical outcome
| العنوان: | Molecular surveillance of pandemic influenza A(H1N1) viruses circulating in Italy from May 2009 to February 2010: association between haemagglutinin mutations and clinical outcome |
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| المؤلفون: | Puzelli, S, Facchini, M, De Marco, M. A, Palmieri, A, Spagnolo, D, Boros, S, Corcioli, F, Trotta, D, Bagnarelli, P, Cassone, A, Rezza, G, Pompa, M. G, Oleari, F, Donatelli, I, Capobianchi, Mr, Vitale, F, D'Agaro, P, Esposito, C, Ghisetti, V, Ansaldi, F, Zanetti, A, Nelli, Lc, Baldanti, F., AZZI, ANNA, FADDA, GIUSEPPE, PALU', GIORGIO |
| المساهمون: | Puzelli, S, Facchini, M, De Marco, M. A, Palmieri, A, Spagnolo, D, Boros, S, Corcioli, F, Trotta, D, Bagnarelli, P, Azzi, Anna, Cassone, A, Rezza, G, Pompa, M. G, Oleari, F, Donatelli, I, Capobianchi, Mr, Fadda, Giuseppe, Palu', Giorgio, Vitale, F, D'Agaro, P, Esposito, C, Ghisetti, V, Ansaldi, F, Zanetti, A, Nelli, Lc, Baldanti, F. |
| سنة النشر: | 2010 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: | Adolescent, Adult, Age Distribution, Aged, Amino Acid Substitution, Child, Preschool, Female, Hemagglutinin, Human, Infant, Influenza A Virus, H1N1 Subtype, Influenza, Italy, Male, Middle Aged, Mutation, Population Surveillance, Reverse Transcriptase Polymerase Chain Reaction, Severity of Illness Index, Sex Distribution, Young Adult, Pandemics |
| الوصف: | Haemagglutinin sequences of pandemic influenza A(H1N1) viruses circulating in Italy were examined, focusing on amino acid changes at position 222 because of its suggested pathogenic relevance. Among 169 patients, the D222G substitution was detected in three of 52 (5.8%) severe cases and in one of 117 (0.9%) mild cases, whereas the D222E mutation was more frequent and evenly distributed in mild (31.6%) and severe cases (38.4%). A cluster of D222E viruses among school children confirms reported human-to-human transmission of viruses mutated at amino acid position 222. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/21087581; info:eu-repo/semantics/altIdentifier/wos/WOS:000283655400002; volume:15; issue:43; journal:EUROSURVEILLANCE; http://hdl.handle.net/11577/3197351Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-79952117723; http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19696Test |
| الإتاحة: | http://hdl.handle.net/11577/3197351Test http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19696Test |
| رقم الانضمام: | edsbas.50BE4A58 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |