التفاصيل البيبلوغرافية
| العنوان: |
T cell activation determined by T cell receptor number and tunable thresholds |
| المؤلفون: |
Viola, A, Lanzavecchia, A |
| المساهمون: |
Viola, A, Lanzavecchia, A |
| سنة النشر: |
1996 |
| المجموعة: |
Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: |
Antibodie, Antigen-Presenting Cell, B7-1 Antigen, CD3 Complex, Cell Line, Clone Cell, Down-Regulation, Enterotoxin, Histocompatibility Antigens Class II, Human, Interferon-gamma, Peptide, Receptors, Antigen, T-Cell, alpha-beta, Superantigen, T-Lymphocyte, Bacterial Toxin, Lymphocyte Activation |
| الوصف: |
The requirements for T cell activation have been reported to vary widely depending on the state of the T cell, the type of antigen-presenting cell, and the nature of the T cell receptor (TCR) ligand. A unitary requirement for T cell responses was revealed by measurement of the number of triggered TCRs. Irrespective of the nature of the triggering ligand, T cells "counted" the number of triggered TCRs and responded when a threshold of approximately 8000 TCRs was reached. The capacity to reach the activation threshold was severely compromised by a reduction in the number of TCRs. Costimulatory signals lowered the activation threshold to approximately 1500 TCRs, thus making T cells more sensitive to antigenic stimulation. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
info:eu-repo/semantics/altIdentifier/pmid/8658175; info:eu-repo/semantics/altIdentifier/wos/WOS:A1996UV47800049; volume:273; issue:5271; firstpage:104-6; journal:SCIENCE; http://hdl.handle.net/11577/3267467Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0030057218 |
| الإتاحة: |
http://hdl.handle.net/11577/3267467Test |
| رقم الانضمام: |
edsbas.937B4F54 |
| قاعدة البيانات: |
BASE |
