التفاصيل البيبلوغرافية
| العنوان: |
T lymphocyte costimulation mediated by reorganization of membrane microdomains |
| المؤلفون: |
Viola, A, Schroeder, S, Sakakibara, Y, Lanzavecchia, A |
| المساهمون: |
Viola, A, Schroeder, S, Sakakibara, Y, Lanzavecchia, A |
| سنة النشر: |
1999 |
| المجموعة: |
Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: |
Antigen-Presenting Cell, CD28 Antigen, CD3 Complex, Cell Membrane, G(M1) Ganglioside, Human, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Membrane Lipid, Phosphorylation, Phosphotyrosine, Receptors, Antigen, T-Cell, Signal Transduction, T-Lymphocyte, Lymphocyte Activation |
| الوصف: |
Although dispensable, costimulation through CD28 facilitates activation of naïve T lymphocytes. CD28 engagement led to the redistribution and clustering of membrane and intracellular kinase-rich raft microdomains at the site of T cell receptor (TCR) engagements. Although not affecting TCR down-regulation, this process led to higher and more stable tyrosine phosphorylation of several substrates and higher consumption of Lck. These results may provide a general mechanism for amplifying receptor signaling by reorganization of membrane microdomains. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
info:eu-repo/semantics/altIdentifier/pmid/9924026; info:eu-repo/semantics/altIdentifier/wos/WOS:000078324400040; volume:283; issue:5402; firstpage:680-2; journal:SCIENCE; http://hdl.handle.net/11577/3267471Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0033613826 |
| الإتاحة: |
http://hdl.handle.net/11577/3267471Test |
| رقم الانضمام: |
edsbas.6303DB20 |
| قاعدة البيانات: |
BASE |
