دورية أكاديمية
Follow-up and quality of life of patients with cryopyrin-associated periodic syndromes treated with Anakinra
| العنوان: | Follow-up and quality of life of patients with cryopyrin-associated periodic syndromes treated with Anakinra |
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| المؤلفون: | Lepore L., Paloni G., Caorsi R., Alessio M., Rigante D., Ruperto N., Cattalini M., Tommasini A., Zulian F., Ventura A., Martini A., Gattorno M. |
| المساهمون: | Lepore, L., Paloni, G., Caorsi, R., Alessio, M., Rigante, D., Ruperto, N., Cattalini, M., Tommasini, A., Zulian, F., Ventura, A., Martini, A., Gattorno, M. |
| بيانات النشر: | Mosby Inc. |
| سنة النشر: | 2010 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: | Adolescent, Adult, Case-Control Studie, Child, Preschool, Cryopyrin-Associated Periodic Syndrome, Female, Follow-Up Studie, Human, Inflammation, Interleukin 1 Receptor Antagonist Protein, Interleukin-1, Male, Phenotype, Quality of Health Care, Quality of Life, Surveys and Questionnaire, Syndrome, Treatment Outcome |
| الوصف: | Objective: To evaluate the quality of life and long-term follow-up of patients enrolled in the Italian registry of cryopyrin-associated periodic syndromes (CAPS). Study design: Since 2004, 20 patients with CAPS were enrolled in a common registry from different Italian Centers of Pediatric Rheumatology; 14 patients were treated with Anakinra in an open fashion. Both treated and untreated patients were routinely followed according to standard of care. The Child Health Questionnaire (CHQ-PF 50) was used to assess the health-related quality of life. Results: The mean duration of follow-up was 37.5 months. In all treated patients, a complete and persistent control of the inflammatory manifestations was observed with no further progression of the disease. At enrollment in the registry, patients showed a poorer health-related quality of life than healthy children in both physical and the psychosocial summary scores. Treatment was associated with a dramatic and sustained amelioration of a variety of measures of poor quality of life, particularly in those concerning the global health perception, bodily pain-discomfort, and other physical domains. Conclusions: Long-term IL-1 blockade produces a significant and persistent improvement in the clinical manifestations associated with the disease and on the overall quality of life. Copyright © 2010 Mosby Inc. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/20472245; info:eu-repo/semantics/altIdentifier/wos/WOS:000279871700029; volume:157; issue:2; firstpage:310; lastpage:315; numberofpages:6; journal:THE JOURNAL OF PEDIATRICS; http://hdl.handle.net/11577/3332208Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-77955291693 |
| DOI: | 10.1016/j.jpeds.2010.02.040 |
| الإتاحة: | https://doi.org/10.1016/j.jpeds.2010.02.040Test http://hdl.handle.net/11577/3332208Test |
| رقم الانضمام: | edsbas.65712516 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jpeds.2010.02.040 |
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