دورية أكاديمية
Circulating levels of dickkopf-1, osteoprotegerin and sclerostin are higher in old compared with young men and women and positively associated with whole-body bone mineral density in older adults
| العنوان: | Circulating levels of dickkopf-1, osteoprotegerin and sclerostin are higher in old compared with young men and women and positively associated with whole-body bone mineral density in older adults |
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| المؤلفون: | Coulson, J., Bagley, L., Barnouin, Y., Bradburn, S., Butler-Browne, G., Gapeyeva, H., Hogrel, J. -Y., Maden-Wilkinson, T., Maier, A. B., Meskers, C., Murgatroyd, C., Narici, M., Pääsuke, M., Sassano, L., Sipilä, S., Al-Shanti, N., Stenroth, L., Jones, D. A., McPhee, J. S. |
| المساهمون: | Coulson, J., Bagley, L., Barnouin, Y., Bradburn, S., Butler-Browne, G., Gapeyeva, H., Hogrel, J. -Y., Maden-Wilkinson, T., Maier, A. B., Meskers, C., Murgatroyd, C., Narici, M., Pääsuke, M., Sassano, L., Sipilä, S., Al-Shanti, N., Stenroth, L., Jones, D. A., Mcphee, J. S. |
| بيانات النشر: | Springer London |
| سنة النشر: | 2017 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: | dickkopf 1 protein, fibroblast growth factor 23, osteocalcin, osteopontin, osteoprotegerin, sclerostin, adult, aged, Article, blood sampling, body ma, bone density, bone metabolism, bone remodeling, comparative study, controlled study, diet restriction, disease association, dual energy X ray absorptiometry, female, human, lean body weight, male, osteolysi, priority journal, protein blood level, senescence, sex difference, very elderly, whole body bone mineral density |
| الوصف: | Summary: Bone mineral density declines with increasing older age. We examined the levels of circulating factors known to regulate bone metabolism in healthy young and older adults. The circulating levels of dickkopf-1, osteocalcin, osteoprotegerin and sclerostin were positively associated with whole-body bone mineral density (WBMD) in older adults, despite the average WBMD being lower and circulating dickkopf-1, osteoprotegerin and sclerostin being higher in old than young. Introduction: This study aims to investigate the relationship between whole-body bone mineral density (WBMD) and levels of circulating factors with known roles in bone remodelling during ‘healthy’ ageing. Methods: WBMD and fasting plasma concentrations of dickkopf-1, fibroblast growth factor-23, osteocalcin, osteoprotegerin, osteopontin and sclerostin were measured in 272 older subjects (69 to 81 years; 52% female) and 171 younger subjects (18–30 years; 53% female). Results: WBMD was lower in old than young. Circulating osteocalcin was lower in old compared with young, while dickkopf-1, osteoprotegerin and sclerostin were higher in old compared with young. These circulating factors were each positively associated with WBMD in the older adults and the relationships remained after adjustment for covariates (r values ranging from 0.174 to 0.254, all p < 0.01). In multivariate regression, the body mass index, circulating sclerostin and whole-body lean mass together accounted for 13.8% of the variation with WBMD in the older adults. In young adults, dickkopf-1 and body mass index together accounted for 7.7% of variation in WBMD. Conclusion: Circulating levels of dickkopf-1, osteocalcin, osteoprotegerin and sclerostin are positively associated with WBMD in community-dwelling older adults, despite the average WBMD being lower and circulating dickkopf-1, osteoprotegerin and sclerostin being higher in old than young. © 2017, International Osteoporosis Foundation and National Osteoporosis Foundation. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000407492700017; volume:28; issue:9; firstpage:2683; lastpage:2689; numberofpages:7; journal:OSTEOPOROSIS INTERNATIONAL; http://hdl.handle.net/11577/3267120Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85020169497; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020169497&doi=10.1007%2fs00198-017-4104-2&partnerID=40&md5=25020acbab7f5d73a5f5b576099af25aTest |
| DOI: | 10.1007/s00198-017-4104-2 |
| الإتاحة: | https://doi.org/10.1007/s00198-017-4104-2Test http://hdl.handle.net/11577/3267120Test |
| رقم الانضمام: | edsbas.6FB8DD18 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00198-017-4104-2 |
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