دورية أكاديمية
ω-3 Polyunsaturated fatty acid biomarkers and coronary heart disease: Pooling project of 19 cohort studies
| العنوان: | ω-3 Polyunsaturated fatty acid biomarkers and coronary heart disease: Pooling project of 19 cohort studies |
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| المؤلفون: | Del Gobbo, L, Imamura, F, Aslibekyan, S, Marklund, M, Virtanen, J, Wennberg, M, Yakoob, M, Chiuve, S, Dela Cruz, L, Frazier-Wood, A, Fretts, A, Guallar, E, Matsumoto, C, Prem, K, Tanaka, T, Wu, J, Zhou, X, Helmer, C, Ingelsson, E, Yuan, J, Barberger-Gateau, P, Campos, H, Chaves, P, Djoussé, L, Giles, G, Gómez-Aracena, J, Hodge, A, Hu, F, Jansson, J, Johansson, I, Khaw, K, Koh, W, Lemaitre, R, Lind, L, Luben, R, Rimm, E, Risérus, U, Samieri, C, Franks, P, Siscovick, D, Stampfer, M, Steffen, L, Steffen, B, Tsai, M, Van Dam, R, Voutilainen, S, Willett, W, Woodward, M, Mozaffarian, D |
| بيانات النشر: | American Medical Association |
| سنة النشر: | 2016 |
| المجموعة: | Oxford University Research Archive (ORA) |
| الوصف: | Importance: The role of ω-3 polyunsaturated fatty acids for primary prevention of coronary heart disease (CHD) remains controversial. Most prior longitudinal studies evaluated self-reported consumption rather than biomarkers.Objective: To evaluate biomarkers of seafood-derived eicosapentaenoic acid (EPA; 20:5 ω-3), docosapentaenoic acid (DPA; 22:5 ω-3), and docosahexaenoic acid (DHA; 22:6 ω-3) and plant-derived α-linolenic acid (ALA; 18:3 ω-3) for incident CHD.Data Sources: A global consortium of 19 studies identified by November 2014.Study Selection: Available prospective (cohort, nested case-control) or retrospective studies with circulating or tissue ω-3 biomarkers and ascertained CHD. Data Extraction and Synthesis: Each study conducted standardized, individual-level analysis using harmonized models, exposures, outcomes, and covariates. Findings were centrally pooled using random-effects meta-analysis. Heterogeneity was examined by age, sex, race, diabetes, statins, aspirin, ω-6 levels, and FADS desaturase genes.Main Outcomes and Measures: Incident total CHD, fatal CHD, and nonfatal myocardial infarction (MI).Results: The 19 studies comprised 16 countries, 45 637 unique individuals, and 7973 total CHD, 2781 fatal CHD, and 7157 nonfatal MI events, with ω-3 measures in total plasma, phospholipids, cholesterol esters, and adipose tissue. Median age at baselinewas 59 years (range, 18-97 years), and 28 660 (62.8%)were male. In continuous (per 1-SD increase) multivariable-adjusted analyses, the ω-3 biomarkers ALA, DPA, and DHAwere associated with a lower risk of fatal CHD, with relative risks (RRs) of 0.91 (95%CI, 0.84-0.98) for ALA, 0.90 (95%CI, 0.85-0.96) for DPA, and 0.90 (95%CI, 0.84-0.96) for DHA. Although DPA was associated with a lower risk of total CHD (RR, 0.94; 95%CI, 0.90-0.99), ALA (RR, 1.00; 95%CI, 0.95-1.05), EPA (RR, 0.94; 95%CI, 0.87-1.02), and DHA (RR, 0.95; 95%CI, 0.91-1.00)were not. Significant associations with nonfatal MIwere not evident. Associations appeared generally stronger in ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://ora.ox.ac.uk/objects/uuid:2243512f-7b57-4b13-939c-77ce3ed84033Test; https://doi.org/10.1001/jamainternmed.2016.2925Test |
| DOI: | 10.1001/jamainternmed.2016.2925 |
| الإتاحة: | https://doi.org/10.1001/jamainternmed.2016.2925Test https://ora.ox.ac.uk/objects/uuid:2243512f-7b57-4b13-939c-77ce3ed84033Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.DBA5225C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1001/jamainternmed.2016.2925 |
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