المؤلفون: Hunter, David, Nevitt, Michael, Lynch, John, Byers Kraus, Virginia, Katz, Jeffrey N., Collins, Jamie E., Bowes, Mike, Guermazi, Ali, Roemer, Frank W., Losina, Elena

مصطلحات موضوعية: ddc:610

الوصف: Objective To perform a longitudinal validation study of imaging bone biomarkers of knee osteoarthritis (OA) progression. Methods We undertook a nested case–control study within the Osteoarthritis Initiative in knees (one knee per subject) with a Kellgren and Lawrence grade of 1–3. Cases were defined as knees having the combination of medial tibiofemoral radiographic progression and pain progression at the 24-month, 36-month or 48-month follow-up compared with baseline. Controls (n=406) were eligible knees that did not meet both endpoint criteria and included 200 with neither radiographic nor pain progression, 103 with radiographic progression only and 103 with pain progression only. Bone surfaces in medial and lateral femur, tibia and patella compartments were segmented from MR images using active appearance models. Independent variables of primary interest included change from baseline to 24 months in (1) total area of bone and (2) position on three-dimensional (3D) bone shape vectors that discriminate OA versus non-OA shapes. We assessed the association of bone markers changes over 24 months with progression using logistic regression. Results 24-month changes in bone area and shape in all compartments were greater in cases than controls, with ORs of being a case per 1 SD increase in bone area ranging from 1.28 to 1.71 across compartments, and per 1 SD greater change in 3D shape vectors ranging from 1.22 to 1.64. Bone markers were associated most strongly with radiographic progression and only weakly with pain progression. Conclusions In knees with mild-to-moderate radiographic OA, changes in bone area and shape over 24 months are associated with the combination of radiographic and pain progression over 48 months. This finding of association with longer term clinical outcome underscores their potential for being an efficacy of intervention biomarker in clinical trials.

وصف الملف: application/pdf

العلاقة: https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/9665Test; urn:nbn:de:bvb:29-opus4-96653; https://nbn-resolving.org/urn:nbn:de:bvb:29-opus4-96653Test; https://doi.org/10.1136/annrheumdis-2015-207602Test; https://opus4.kobv.de/opus4-fau/files/9665/Hunter_longitudinal.pdfTest

الإتاحة: https://doi.org/10.1136/annrheumdis-2015-207602Test
https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/9665Test
https://nbn-resolving.org/urn:nbn:de:bvb:29-opus4-96653Test
https://opus4.kobv.de/opus4-fau/files/9665/Hunter_longitudinal.pdfTest

المؤلفون: Roemer, Frank W., Guermazi, Ali, Collins, Jamie E., Losina, Elena, Nevitt, Michael C., Lynch, John A., Katz, Jeffrey N., Kwoh, C. Kent, Kraus, Virginia B., Hunter, David J.

مصطلحات موضوعية: ddc:610

الوصف: Background To describe the scoring methodology and MRI assessments used to evaluate the cross-sectional features observed in cases and controls, to define change over time for different MRI features, and to report the extent of changes over a 24-month period in the Foundation for National Institutes of Health Osteoarthritis Biomarkers Consortium study nested within the larger Osteoarthritis Initiative (OAI) Study. Methods We conducted a nested case–control study. Cases (n = 406) were knees having both radiographic and pain progression. Controls (n = 194) were knee osteoarthritis subjects who did not meet the case definition. Groups were matched for Kellgren-Lawrence grade and body mass index. MRIs were acquired using 3 T MRI systems and assessed using the semi-quantitative MOAKS system. MRIs were read at baseline and 24 months for cartilage damage, bone marrow lesions (BML), osteophytes, meniscal damage and extrusion, and Hoffa- and effusion-synovitis. We provide the definition and distribution of change in these biomarkers over time. Results Seventy-three percent of the cases had subregions with BML worsening (vs. 66 % in controls) (p = 0.102). Little change in osteophytes was seen over 24 months. Twenty-eight percent of cases and 10 % of controls had worsening in meniscal scores in at least one subregion (p < 0.001). Seventy-three percent of cases and 53 % of controls had at least one area with worsening in cartilage surface area (p < 0.001). More cases experienced worsening in Hoffa- and effusion synovitis than controls (17 % vs. 6 % (p < 0.001); 41 % vs. 18 % (p < 0.001), respectively). Conclusions A wide range of MRI-detected structural pathologies was present in the FNIH cohort. More severe changes, especially for BMLs, cartilage and meniscal damage, were detected primarily among the case group suggesting that early changes in multiple structural domains are associated with radiographic worsening and symptomatic progression.

وصف الملف: application/pdf

العلاقة: https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/8026Test; urn:nbn:de:bvb:29-opus4-80260; https://nbn-resolving.org/urn:nbn:de:bvb:29-opus4-80260Test; https://doi.org/10.1186/s12891-016-1310-6Test; https://opus4.kobv.de/opus4-fau/files/8026/Roemer_semi-quantitative.pdfTest

الإتاحة: https://doi.org/10.1186/s12891-016-1310-6Test
https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/8026Test
https://nbn-resolving.org/urn:nbn:de:bvb:29-opus4-80260Test
https://opus4.kobv.de/opus4-fau/files/8026/Roemer_semi-quantitative.pdfTest