المؤلفون: Kanoni, Stavroula, Graham, Sarah E., Wang, Yuxuan, Surakka, Ida, Ramdas, Shweta, Zhu, Xiang, Clarke, Shoa L., Bhatti, Konain Fatima, Vedantam, Sailaja, Winkler, Thomas W., Locke, Adam E., Marouli, Eirini, Zajac, Greg J.M., Wu, Kuan Han H., Ntalla, Ioanna, Hui, Qin, Klarin, Derek, Hilliard, Austin T., Wang, Zeyuan, Xue, Chao, Thorleifsson, Gudmar, Helgadottir, Anna, Gudbjartsson, Daniel F., Holm, Hilma, Ólafsson, Ísleifur, Hwang, Mi Yeong, Han, Sohee, Akiyama, Masato, Sakaue, Saori, Terao, Chikashi, Kanai, Masahiro, Zhou, Wei, Brumpton, Ben M., Rasheed, Humaira, Havulinna, Aki S., Veturi, Yogasudha, Pacheco, Jennifer Allen, Rosenthal, Elisabeth A., Lingren, Todd, Feng, Qi Ping, Kullo, Iftikhar J., Narita, Akira, Takayama, Jun, Martin, Hilary C., Hunt, Karen A., Trivedi, Bhavi, Haessler, Jeffrey, Giulianini, Franco, Bradford, Yuki, Miller, Jason E., Campbell, Archie, Lin, Kuang, Millwood, Iona Y., Rasheed, Asif, Hindy, George, Faul, Jessica D., Zhao, Wei, Weir, David R., Turman, Constance, Huang, Hongyan, Graff, Mariaelisa, Choudhury, Ananyo, Sengupta, Dhriti, Mahajan, Anubha, Brown, Michael R., Zhang, Weihua, Yu, Ketian, Schmidt, Ellen M., Pandit, Anita, Gustafsson, Stefan, Yin, Xianyong, Luan, Jian’an, Zhao, Jing Hua, Matsuda, Fumihiko, Jang, Hye Mi, Yoon, Kyungheon, Medina-Gomez, Carolina, Pitsillides, Achilleas, Hottenga, Jouke Jan, Wood, Andrew R., Ji, Yingji, Gao, Zishan, Haworth, Simon, Yousri, Noha A., Mitchell, Ruth E., Chai, Jin Fang, Aadahl, Mette, Bjerregaard, Anne A., Yao, Jie, Manichaikul, Ani, Hwu, Chii Min, Hung, Yi Jen, Warren, Helen R., Ramirez, Julia, Bork-Jensen, Jette, Kårhus, Line L., Goel, Anuj, Sabater-Lleal, Maria, Noordam, Raymond, Mauro, Pala, Matteo, Floris, McDaid, Aaron F., Marques-Vidal, Pedro, Wielscher, Matthias, Trompet, Stella, Sattar, Naveed, Møllehave, Line T., Munz, Matthias, Zeng, Lingyao, Huang, Jianfeng, Yang, Bin, Poveda, Alaitz, Kurbasic, Azra, Lamina, Claudia, Forer, Lukas, Scholz, Markus, Galesloot, Tessel E., Bradfield, Jonathan P., Ruotsalainen, Sanni E., Daw, EWarwick W., Zmuda, Joseph M., Mitchell, Jonathan S., Fuchsberger, Christian, Christensen, Henry, Brody, Jennifer A., Vazquez-Moreno, Miguel, Feitosa, Mary F., Wojczynski, Mary K., Wang, Zhe, Preuss, Michael H., Mangino, Massimo, Christofidou, Paraskevi, Verweij, Niek, Benjamins, Jan W., Engmann, Jorgen, Tsao, Noah L., Verma, Anurag, Slieker, Roderick C., Lo, Ken Sin, Zilhao, Nuno R., Le, Phuong, Kleber, Marcus E., Delgado, Graciela E., Huo, Shaofeng, Ikeda, Daisuke D., Iha, Hiroyuki, Yang, Jian, Liu, Jun, Demirkan, Ayşe, Leonard, Hampton L., Marten, Jonathan, Frank, Mirjam, Schmidt, Börge, Smyth, Laura J., Cañadas-Garre, Marisa, Wang, Chaolong, Nakatochi, Masahiro, Wong, Andrew, Hutri-Kähönen, Nina, Sim, Xueling, Xia, Rui, Huerta-Chagoya, Alicia, Fernandez-Lopez, Juan Carlos, Lyssenko, Valeriya, Nongmaithem, Suraj S., Bayyana, Swati, Stringham, Heather M., Irvin, Marguerite R., Oldmeadow, Christopher, Kim, Han Na, Ryu, Seungho, Timmers, Paul R.H.J., Arbeeva, Liubov, Dorajoo, Rajkumar, Lange, Leslie A., Prasad, Gauri, Lorés-Motta, Laura, Pauper, Marc, Long, Jirong, Li, Xiaohui, Theusch, Elizabeth, Takeuchi, Fumihiko, Spracklen, Cassandra N., Loukola, Anu, Bollepalli, Sailalitha, Warner, Sophie C., Wang, Ya Xing, Wei, Wen B., Nutile, Teresa, Ruggiero, Daniela, Sung, Yun Ju, Chen, Shufeng, Liu, Fangchao, Yang, Jingyun, Kentistou, Katherine A., Banas, Bernhard, Nardone, Giuseppe Giovanni, Meidtner, Karina, Bielak, Lawrence F., Smith, Jennifer A., Hebbar, Prashantha, Farmaki, Aliki Eleni, Hofer, Edith, Lin, Maoxuan, Concas, Maria Pina, Vaccargiu, Simona, van der Most, Peter J., Pitkänen, Niina, Cade, Brian E., van der Laan, Sander W., Chitrala, Kumaraswamy Naidu, Weiss, Stefan, Bentley, Amy R., Doumatey, Ayo P., Adeyemo, Adebowale A., Lee, Jong Young, Petersen, Eva R.B., Nielsen, Aneta A., Choi, Hyeok Sun, Nethander, Maria, Freitag-Wolf, Sandra, Southam, Lorraine, Rayner, Nigel W., Wang, Carol A., Lin, Shih Yi, Wang, Jun Sing, Couture, Christian, Lyytikäinen, Leo Pekka, Nikus, Kjell, Cuellar-Partida, Gabriel, Vestergaard, Henrik, Hidalgo, Bertha, Giannakopoulou, Olga, Cai, Qiuyin, Obura, Morgan O., van Setten, Jessica, Li, Xiaoyin, Liang, Jingjing, Tang, Hua, Terzikhan, Natalie, Shin, Jae Hun, Jackson, Rebecca D., Reiner, Alexander P., Martin, Lisa Warsinger, Chen, Zhengming, Li, Liming, Kawaguchi, Takahisa, Thiery, Joachim, Bis, Joshua C., Launer, Lenore J., Li, Huaixing, Nalls, Mike A., Raitakari, Olli T., Ichihara, Sahoko, Wild, Sarah H., Nelson, Christopher P., Campbell, Harry, Jäger, Susanne, Nabika, Toru, Al-Mulla, Fahd, Niinikoski, Harri, Braund, Peter S., Kolcic, Ivana, Kovacs, Peter, Giardoglou, Tota, Katsuya, Tomohiro, de Kleijn, Dominique, de Borst, Gert J., Kim, Eung Kweon, Adams, Hieab H.H., Ikram, M. Arfan, Zhu, Xiaofeng, Asselbergs, Folkert W., Kraaijeveld, Adriaan O., Beulens, Joline W.J., Shu, Xiao Ou, Rallidis, Loukianos S., Pedersen, Oluf, Hansen, Torben, Mitchell, Paul, Hewitt, Alex W., Kähönen, Mika, Pérusse, Louis, Bouchard, Claude, Tönjes, Anke, Chen, Yii Der Ida, Pennell, Craig E., Mori, Trevor A., Lieb, Wolfgang, Franke, Andre, Ohlsson, Claes, Mellström, Dan, Cho, Yoon Shin, Lee, Hyejin, Yuan, Jian Min, Koh, Woon Puay, Rhee, Sang Youl, Woo, Jeong Taek, Heid, Iris M., Stark, Klaus J., Zimmermann, Martina E., Völzke, Henry, Homuth, Georg, Evans, Michele K., Zonderman, Alan B., Polasek, Ozren, Pasterkamp, Gerard, Hoefer, Imo E., Redline, Susan, Pahkala, Katja, Oldehinkel, Albertine J., Snieder, Harold, Biino, Ginevra, Schmidt, Reinhold, Schmidt, Helena, Bandinelli, Stefania, Dedoussis, George, Thanaraj, Thangavel Alphonse, Kardia, Sharon L.R., Peyser, Patricia A., Kato, Norihiro, Schulze, Matthias B., Girotto, Giorgia, Böger, Carsten A., Jung, Bettina, Joshi, Peter K., Bennett, David A., De Jager, Philip L., Lu, Xiangfeng, Mamakou, Vasiliki, Brown, Morris, Caulfield, Mark J., Munroe, Patricia B., Guo, Xiuqing, Ciullo, Marina, Jonas, Jost B., Samani, Nilesh J., Kaprio, Jaakko, Pajukanta, Päivi, Tusié-Luna, Teresa, Aguilar-Salinas, Carlos A., Adair, Linda S., Bechayda, Sonny Augustin, de Silva, H. Janaka, Wickremasinghe, Ananda R., Krauss, Ronald M., Wu, Jer Yuarn, Zheng, Wei, Hollander, Anneke Iden, Bharadwaj, Dwaipayan, Correa, Adolfo, Wilson, James G., Lind, Lars, Heng, Chew Kiat, Nelson, Amanda E., Golightly, Yvonne M., Wilson, James F., Penninx, Brenda, Kim, Hyung Lae, Attia, John, Scott, Rodney J., Rao, D. C., Arnett, Donna K., Hunt, Steven C., Walker, Mark, Koistinen, Heikki A., Chandak, Giriraj R., Mercader, Josep M., Costanzo, Maria C., Jang, Dongkeun, Burtt, Noël P., Villalpando, Clicerio Gonzalez, Orozco, Lorena, Fornage, Myriam, Tai, EShyong S., van Dam, Rob M., Lehtimäki, Terho, Chaturvedi, Nish, Yokota, Mitsuhiro, Liu, Jianjun, Reilly, Dermot F., McKnight, Amy Jayne, Kee, Frank, Jöckel, Karl Heinz, McCarthy, Mark I., Palmer, Colin N.A., Vitart, Veronique, Hayward, Caroline, Simonsick, Eleanor, van Duijn, Cornelia M., Jin, Zi Bing, Qu, Jia, Hishigaki, Haretsugu, Lin, Xu, März, Winfried, Gudnason, Vilmundur, Tardif, Jean Claude, Lettre, Guillaume, Hart, Leen M.‘t, Elders, Petra J.M., Damrauer, Scott M., Kumari, Meena, Kivimaki, Mika, van der Harst, Pim, Spector, Tim D., Loos, Ruth J.F., Province, Michael A., Parra, Esteban J., Cruz, Miguel, Psaty, Bruce M., Brandslund, Ivan, Pramstaller, Peter P., Rotimi, Charles N., Christensen, Kaare, Ripatti, Samuli, Widén, Elisabeth, Hakonarson, Hakon, Grant, Struan F.A., Kiemeney, Lambertus A.L.M., de Graaf, Jacqueline, Loeffler, Markus, Kronenberg, Florian, Gu, Dongfeng, Erdmann, Jeanette, Schunkert, Heribert, Franks, Paul W., Linneberg, Allan, Jukema, J. Wouter, Khera, Amit V., Männikkö, Minna, Jarvelin, Marjo Riitta, Kutalik, Zoltan, Francesco, Cucca, Mook-Kanamori, Dennis O., van Dijk, Ko Willems, Watkins, Hugh, Strachan, David P., Grarup, Niels, Sever, Peter, Poulter, Neil, Chuang, Lee Ming, Rotter, Jerome I., Dantoft, Thomas M., Karpe, Fredrik, Neville, Matt J., Timpson, Nicholas J., Cheng, Ching Yu, Wong, Tien Yin, Khor, Chiea Chuen, Li, Hengtong, Sabanayagam, Charumathi, Peters, Annette, Gieger, Christian, Hattersley, Andrew T., Pedersen, Nancy L., Magnusson, Patrik K.E., Boomsma, Dorret I., Willemsen, Allegonda H.M., Cupples, LAdrienne A., van Meurs, Joyce B.J., Ghanbari, Mohsen, Gordon-Larsen, Penny, Huang, Wei, Kim, Young Jin, Tabara, Yasuharu, Wareham, Nicholas J., Langenberg, Claudia, Zeggini, Eleftheria, Kuusisto, Johanna, Laakso, Markku, Ingelsson, Erik, Abecasis, Goncalo, Chambers, John C., Kooner, Jaspal S., de Vries, Paul S., Morrison, Alanna C., Hazelhurst, Scott, Ramsay, Michèle, North, Kari E., Daviglus, Martha, Kraft, Peter, Martin, Nicholas G., Whitfield, John B., Abbas, Shahid, Saleheen, Danish, Walters, Robin G., Holmes, Michael V., Black, Corri, Smith, Blair H., Baras, Aris, Justice, Anne E., Buring, Julie E., Ridker, Paul M., Chasman, Daniel I., Kooperberg, Charles, Tamiya, Gen, Yamamoto, Masayuki, van Heel, David A., Trembath, Richard C., Wei, Wei Qi, Jarvik, Gail P., Namjou, Bahram, Hayes, M. Geoffrey, Ritchie, Marylyn D., Jousilahti, Pekka, Salomaa, Veikko, Hveem, Kristian, Åsvold, Bjørn Olav, Kubo, Michiaki, Kamatani, Yoichiro, Okada, Yukinori, Murakami, Yoshinori, Kim, Bong Jo, Thorsteinsdottir, Unnur, Stefansson, Kari, Zhang, Jifeng, Chen, YEugene E., Ho, Yuk Lam, Lynch, Julie A., Rader, Daniel J., Tsao, Philip S., Chang, Kyong Mi, Cho, Kelly, O’Donnell, Christopher J., Gaziano, John M., Wilson, Peter W.F., Frayling, Timothy M., Hirschhorn, Joel N., Kathiresan, Sekar, Mohlke, Karen L., Sun, Yan V., Morris, Andrew P., Boehnke, Michael, Brown, Christopher D., Natarajan, Pradeep, Deloukas, Panos, Willer, Cristen J., Assimes, Themistocles L., Peloso, Gina M.

المساهمون: Other departments, Faculty of Medicine, Engineering and Natural Sciences, Health Sciences

مصطلحات موضوعية: Lífefna- og sameindalíffræði, Cholesterol, Genetics, Genome-wide association study, GWAS, Lipids, Ecology, Evolution, Behavior and Systematics, Cell Biology

الوصف: Funding Information: GMP, PN, and CW are supported by NHLBI R01HL127564. GMP and PN are supported by R01HL142711. AG acknowledge support from the Wellcome Trust (201543/B/16/Z), European Union Seventh Framework Programme FP7/2007–2013 under grant agreement no. HEALTH-F2-2013–601456 (CVGenes@Target) & the TriPartite Immunometabolism Consortium [TrIC]-Novo Nordisk Foundation’s Grant number NNF15CC0018486. JMM is supported by American Diabetes Association Innovative and Clinical Translational Award 1–19-ICTS-068. SR was supported by the Academy of Finland Center of Excellence in Complex Disease Genetics (Grant No 312062), the Finnish Foundation for Cardiovascular Research, the Sigrid Juselius Foundation, and University of Helsinki HiLIFE Fellow and Grand Challenge grants. EW was supported by the Finnish innovation fund Sitra (EW) and Finska Läkaresällskapet. CNS was supported by American Heart Association Postdoctoral Fellowships 15POST24470131 and 17POST33650016. Charles N Rotimi is supported by Z01HG200362. Zhe Wang, Michael H Preuss, and Ruth JF Loos are supported by R01HL142302. NJT is a Wellcome Trust Investigator (202802/Z/16/Z), is the PI of the Avon Longitudinal Study of Parents and Children (MRC & WT 217065/Z/19/Z), is supported by the University of Bristol NIHR Biomedical Research Centre (BRC-1215–2001) and the MRC Integrative Epidemiology Unit (MC_UU_00011), and works within the CRUK Integrative Cancer Epidemiology Programme (C18281/A19169). Ruth E Mitchell is a member of the MRC Integrative Epidemiology Unit at the University of Bristol funded by the MRC (MC_UU_00011/1). Simon Haworth is supported by the UK National Institute for Health Research Academic Clinical Fellowship. Paul S. de Vries was supported by American Heart Association grant number 18CDA34110116. Julia Ramierz acknowledges support by the People Programme of the European Union’s Seventh Framework Programme grant n° 608765 and Marie Sklodowska-Curie grant n° 786833. Maria Sabater-Lleal is supported by a Miguel Servet contract from ...

العلاقة: Genome Biology; 23(1); http://www.scopus.com/inward/record.url?scp=85144774123&partnerID=8YFLogxKTest; Kanoni , S , Graham , S E , Wang , Y , Surakka , I , Ramdas , S , Zhu , X , Clarke , S L , Bhatti , K F , Vedantam , S , Winkler , T W , Locke , A E , Marouli , E , Zajac , G J M , Wu , K H H , Ntalla , I , Hui , Q , Klarin , D , Hilliard , A T , Wang , Z , Xue , C , Thorleifsson , G , Helgadottir , A , Gudbjartsson , D F , Holm , H , Ólafsson , Í , Hwang , M Y , Han , S , Akiyama , M , Sakaue , S , Terao , C , Kanai , M , Zhou , W , Brumpton , B M , Rasheed , H , Havulinna , A S , Veturi , Y , Pacheco , J A , Rosenthal , E A , Lingren , T , Feng , Q P , Kullo , I J , Narita , A , Takayama , J , Martin , H C , Hunt , K A , Trivedi , B , Haessler , J , Giulianini , F , Bradford , Y , Miller , J E , Campbell , A , Lin , K , Millwood , I Y , Rasheed , A , Hindy , G , Faul , J D , Zhao , W , Weir , D R , Turman , C , Huang , H , Graff , M , Choudhury , A , Sengupta , D , Mahajan , A , Brown , M R , Zhang , W , Yu , K , Schmidt , E M , Pandit , A , Gustafsson , S , Yin , X , Luan , J , Zhao , J H , Matsuda , F , Jang , H M , Yoon , K , Medina-Gomez , C , Pitsillides , A , Hottenga , J J , Wood , A R , Ji , Y , Gao , Z , Haworth , S , Yousri , N A , Mitchell , R E , Chai , J F , Aadahl , M , Bjerregaard , A A , Yao , J , Manichaikul , A , Hwu , C M , Hung , Y J , Warren , H R , Ramirez , J , Bork-Jensen , J , Kårhus , L L , Goel , A , Sabater-Lleal , M , Noordam , R , Mauro , P , Matteo , F , McDaid , A F , Marques-Vidal , P , Wielscher , M , Trompet , S , Sattar , N , Møllehave , L T , Munz , M , Zeng , L , Huang , J , Yang , B , Poveda , A , Kurbasic , A , Lamina , C , Forer , L , Scholz , M , Galesloot , T E , Bradfield , J P , Ruotsalainen , S E , Daw , EW W , Zmuda , J M , Mitchell , J S , Fuchsberger , C , Christensen , H , Brody , J A , Vazquez-Moreno , M , Feitosa , M F , Wojczynski , M K , Wang , Z , Preuss , M H , Mangino , M , Christofidou , P , Verweij , N , Benjamins , J W , Engmann , J , Tsao , N L , Verma , A , Slieker , R C , Lo , K S , Zilhao , N R , Le , P , Kleber , M E , Delgado , G E , Huo , S , Ikeda , D D , Iha , H , Yang , J , Liu , J , Demirkan , A , Leonard , H L , Marten , J , Frank , M , Schmidt , B , Smyth , L J , Cañadas-Garre , M , Wang , C , Nakatochi , M , Wong , A , Hutri-Kähönen , N , Sim , X , Xia , R , Huerta-Chagoya , A , Fernandez-Lopez , J C , Lyssenko , V , Nongmaithem , S S , Bayyana , S , Stringham , H M , Irvin , M R , Oldmeadow , C , Kim , H N , Ryu , S , Timmers , P R H J , Arbeeva , L , Dorajoo , R , Lange , L A , Prasad , G , Lorés-Motta , L , Pauper , M , Long , J , Li , X , Theusch , E , Takeuchi , F , Spracklen , C N , Loukola , A , Bollepalli , S , Warner , S C , Wang , Y X , Wei , W B , Nutile , T , Ruggiero , D , Sung , Y J , Chen , S , Liu , F , Yang , J , Kentistou , K A , Banas , B , Nardone , G G , Meidtner , K , Bielak , L F , Smith , J A , Hebbar , P , Farmaki , A E , Hofer , E , Lin , M , Concas , M P , Vaccargiu , S , van der Most , P J , Pitkänen , N , Cade , B E , van der Laan , S W , Chitrala , K N , Weiss , S , Bentley , A R , Doumatey , A P , Adeyemo , A A , Lee , J Y , Petersen , E R B , Nielsen , A A , Choi , H S , Nethander , M , Freitag-Wolf , S , Southam , L , Rayner , N W , Wang , C A , Lin , S Y , Wang , J S , Couture , C , Lyytikäinen , L P , Nikus , K , Cuellar-Partida , G , Vestergaard , H , Hidalgo , B , Giannakopoulou , O , Cai , Q , Obura , M O , van Setten , J , Li , X , Liang , J , Tang , H , Terzikhan , N , Shin , J H , Jackson , R D , Reiner , A P , Martin , L W , Chen , Z , Li , L , Kawaguchi , T , Thiery , J , Bis , J C , Launer , L J , Li , H , Nalls , M A , Raitakari , O T , Ichihara , S , Wild , S H , Nelson , C P , Campbell , H , Jäger , S , Nabika , T , Al-Mulla , F , Niinikoski , H , Braund , P S , Kolcic , I , Kovacs , P , Giardoglou , T , Katsuya , T , de Kleijn , D , de Borst , G J , Kim , E K , Adams , H H H , Ikram , M A , Zhu , X , Asselbergs , F W , Kraaijeveld , A O , Beulens , J W J , Shu , X O , Rallidis , L S , Pedersen , O , Hansen , T , Mitchell , P , Hewitt , A W , Kähönen , M , Pérusse , L , Bouchard , C , Tönjes , A , Chen , Y D I , Pennell , C E , Mori , T A , Lieb , W , Franke , A , Ohlsson , C , Mellström , D , Cho , Y S , Lee , H , Yuan , J M , Koh , W P , Rhee , S Y , Woo , J T , Heid , I M , Stark , K J , Zimmermann , M E , Völzke , H , Homuth , G , Evans , M K , Zonderman , A B , Polasek , O , Pasterkamp , G , Hoefer , I E , Redline , S , Pahkala , K , Oldehinkel , A J , Snieder , H , Biino , G , Schmidt , R , Schmidt , H , Bandinelli , S , Dedoussis , G , Thanaraj , T A , Kardia , S L R , Peyser , P A , Kato , N , Schulze , M B , Girotto , G , Böger , C A , Jung , B , Joshi , P K , Bennett , D A , De Jager , P L , Lu , X , Mamakou , V , Brown , M , Caulfield , M J , Munroe , P B , Guo , X , Ciullo , M , Jonas , J B , Samani , N J , Kaprio , J , Pajukanta , P , Tusié-Luna , T , Aguilar-Salinas , C A , Adair , L S , Bechayda , S A , de Silva , H J , Wickremasinghe , A R , Krauss , R M , Wu , J Y , Zheng , W , Hollander , A I , Bharadwaj , D , Correa , A , Wilson , J G , Lind , L , Heng , C K , Nelson , A E , Golightly , Y M , Wilson , J F , Penninx , B , Kim , H L , Attia , J , Scott , R J , Rao , D C , Arnett , D K , Hunt , S C , Walker , M , Koistinen , H A , Chandak , G R , Mercader , J M , Costanzo , M C , Jang , D , Burtt , N P , Villalpando , C G , Orozco , L , Fornage , M , Tai , ES S , van Dam , R M , Lehtimäki , T , Chaturvedi , N , Yokota , M , Liu , J , Reilly , D F , McKnight , A J , Kee , F , Jöckel , K H , McCarthy , M I , Palmer , C N A , Vitart , V , Hayward , C , Simonsick , E , van Duijn , C M , Jin , Z B , Qu , J , Hishigaki , H , Lin , X , März , W , Gudnason , V , Tardif , J C , Lettre , G , Hart , L M , Elders , P J M , Damrauer , S M , Kumari , M , Kivimaki , M , van der Harst , P , Spector , T D , Loos , R J F , Province , M A , Parra , E J , Cruz , M , Psaty , B M , Brandslund , I , Pramstaller , P P , Rotimi , C N , Christensen , K , Ripatti , S , Widén , E , Hakonarson , H , Grant , S F A , Kiemeney , L A L M , de Graaf , J , Loeffler , M , Kronenberg , F , Gu , D , Erdmann , J , Schunkert , H , Franks , P W , Linneberg , A , Jukema , J W , Khera , A V , Männikkö , M , Jarvelin , M R , Kutalik , Z , Francesco , C , Mook-Kanamori , D O , van Dijk , K W , Watkins , H , Strachan , D P , Grarup , N , Sever , P , Poulter , N , Chuang , L M , Rotter , J I , Dantoft , T M , Karpe , F , Neville , M J , Timpson , N J , Cheng , C Y , Wong , T Y , Khor , C C , Li , H , Sabanayagam , C , Peters , A , Gieger , C , Hattersley , A T , Pedersen , N L , Magnusson , P K E , Boomsma , D I , Willemsen , A H M , Cupples , LA A , van Meurs , J B J , Ghanbari , M , Gordon-Larsen , P , Huang , W , Kim , Y J , Tabara , Y , Wareham , N J , Langenberg , C , Zeggini , E , Kuusisto , J , Laakso , M , Ingelsson , E , Abecasis , G , Chambers , J C , Kooner , J S , de Vries , P S , Morrison , A C , Hazelhurst , S , Ramsay , M , North , K E , Daviglus , M , Kraft , P , Martin , N G , Whitfield , J B , Abbas , S , Saleheen , D , Walters , R G , Holmes , M V , Black , C , Smith , B H , Baras , A , Justice , A E , Buring , J E , Ridker , P M , Chasman , D I , Kooperberg , C , Tamiya , G , Yamamoto , M , van Heel , D A , Trembath , R C , Wei , W Q , Jarvik , G P , Namjou , B , Hayes , M G , Ritchie , M D , Jousilahti , P , Salomaa , V , Hveem , K , Åsvold , B O , Kubo , M , Kamatani , Y , Okada , Y , Murakami , Y , Kim , B J , Thorsteinsdottir , U , Stefansson , K , Zhang , J , Chen , YE E , Ho , Y L , Lynch , J A , Rader , D J , Tsao , P S , Chang , K M , Cho , K , O’Donnell , C J , Gaziano , J M , Wilson , P W F , Frayling , T M , Hirschhorn , J N , Kathiresan , S , Mohlke , K L , Sun , Y V , Morris , A P , Boehnke , M , Brown , C D , Natarajan , P , Deloukas , P , Willer , C J , Assimes , T L & Peloso , G M 2022 , ' Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis ' , Genome Biology , vol. 23 , no. 1 , 268 . https://doi.org/10.1186/s13059-022-02837-1Test; ec260c87-ebc4-42fb-8b89-7565aebbe229; 85144774123; https://hdl.handle.net/20.500.11815/4020Test

الإتاحة: https://doi.org/20.500.11815/4020Test
https://doi.org/10.1186/s13059-022-02837-1Test
https://hdl.handle.net/20.500.11815/4020Test

المؤلفون: Frey, Vanessa N., Butz, Kevin, Zimmermann, Georg, Kunz, Alexander, Höller, Yvonne, Golaszewski, Stefan, Trinka, Eugen, Nardone, Raffaele

المساهمون: Sálfræðideild (HA), Faculty of Psychology (UA), Hug- og félagsvísindasvið (HA), School of Humanities and Social Sciences (UA), Háskólinn á Akureyri, University of Akureyri

مصطلحات موضوعية: Hands, Bodily self perception, Nervous system, Neuroplasticity, Hendur, Líkamsvitund, Taugakerfi

الوصف: Synchronous visuotactile stimulation on the own hidden hand and a visible fake limb can alter bodily self-perception and influence spontaneous neuroplasticity. The rubber hand illusion (RHI) paradigm experimentally produces an illusion of rubber hand ownership and arm shift by simultaneously stroking a rubber hand in view and a participant's visually occluded hand. The aim of this cross-over, placebo-controlled, single-blind study was to assess whether RHI, in combination with high-frequency repetitive transcranial magnetic stimulation (rTMS) given as intermittent (excitatory) theta burst stimulation (iTBS) applied over the hand area of the primary sensory region (S1) can enhance tactile sensation in a group of 21 healthy subjects and one patient with cervical spinal cord injury. Four sessions covered all combinations of real and sham stimulations of the RHI and the TBS: Real TBS and real RHI, real TBS and sham RHI, sham TBS and real RHI, and both conditions sham. The condition sham TBS and real RHI shows the greatest effect on the proprioceptive drift (median 2.3 cm, IQR 2) and on the score of RHI questionnaires (median 3, IQR 2) in the control group as well as in the real-real condition (median 2, IQR 2). The sham TBS and real RHI condition also shows the best results in the electrical perception test of the patient (median 1.9 mA). Conversely, the upregulation of the cortical excitability of S1 via TBS seems to impair the effect of the RHI. This might be due to a strengthening of the top-down connection between the central nervous system and the periphery, diminishing the RHI. This finding helps in understanding the mechanisms of top-down and bottom-up mechanisms in healthy subjects and patients with spinal cord injury. The RHI paradigm could represent an interesting therapeutic approach in improving tactile sensation and rTMS techniques could modulate these effects. Yet, further studies are needed, to examine the direction of the interaction effect of TMS and RH. ; Spinal Cord Injury and Tissue Regeneration ...

وصف الملف: 1-8

العلاقة: Neural Plasticity;2020; Frey, V. N., Butz, K., Zimmermann, G., Kunz, A., Höller, Y., Golaszewski, S., . . . Nardone, R. (2020). Effects of rubber hand illusion and excitatory theta burst stimulation on tactile sensation: A pilot study. Neural Plasticity, 2020, 1-8. doi:10.1155/2020/3069639; 1687-5443 (eISSN); https://hdl.handle.net/20.500.11815/1805Test; Neural Plasticity

الإتاحة: https://doi.org/20.500.11815/1805Test
https://doi.org/10.1155/2020/3069639Test
https://hdl.handle.net/20.500.11815/1805Test

المؤلفون: Nardone, Raffaele, Golaszewski, Stefan, Schwenker, Kerstin, Brigo, Francesco, Maccarrone, Miriam, Versace, Viviana, Sebastianelli, Luca, Saltuari, Leopold, Höller, Yvonne

المساهمون: School of Humanities and Social Sciences

مصطلحات موضوعية: Taugavísindi, Taugafrumur, Taugasjúkdómar, Cholinergic transmission, Idiopathic normal-pressure hydrocephalus, Short latency afferent inhibition, Transcranial magnetic stimulation, Neurology, Neurology (clinical), Psychiatry and Mental Health, Biological Psychiatry

الوصف: Funding Information: Open access funding provided by Paracelsus Medical University. Publisher Copyright: © 2019, The Author(s). ; The pathophysiological mechanisms of cognitive and gait disturbances in subjects with normal-pressure hydrocephalus (NPH) are still unclear. Cholinergic and other neurotransmitter abnormalities have been reported in animal models of NPH. The objective of this study was to evaluate the short latency afferent inhibition (SAI), a transcranial magnetic stimulation protocol which gives the possibility to test an inhibitory cholinergic circuit in the human brain, in subjects with idiopathic NPH (iNPH). We applied SAI technique in twenty iNPH patients before ventricular shunt surgery. Besides SAI, also the resting motor threshold and the short intracortical inhibition to paired stimulation were assessed. A significant reduction of the SAI (p = 0.016), associated with a less pronounced decrease of the resting motor threshold and the short latency intracortical inhibition to paired stimulation, were observed in patients with iNPH at baseline evaluation. We also found significant (p < 0.001) correlations between SAI values and the gait function tests, as well as between SAI and the neuropsychological tests. These findings suggest that the impairment of cholinergic neurons markedly contributes to cognitive decline and gait impairment in subjects with iNPH. ; The pathophysiological mechanisms of cognitive and gait disturbances in subjects with normal-pressure hydrocephalus (NPH) are still unclear. Cholinergic and other neurotransmitter abnormalities have been reported in animal models of NPH. The objective of this study was to evaluate the short latency afferent inhibition (SAI), a transcranial magnetic stimulation protocol which gives the possibility to test an inhibitory cholinergic circuit in the human brain, in subjects with idiopathic NPH (iNPH). We applied SAI technique in twenty iNPH patients before ventricular shunt surgery. Besides SAI, also the resting motor threshold and the short ...

وصف الملف: 1073-1080

العلاقة: Journal of Neural Transmission; 126(8); http://www.scopus.com/inward/record.url?scp=85067840540&partnerID=8YFLogxKTest; Nardone , R , Golaszewski , S , Schwenker , K , Brigo , F , Maccarrone , M , Versace , V , Sebastianelli , L , Saltuari , L & Höller , Y 2019 , ' Cholinergic transmission is impaired in patients with idiopathic normal-pressure hydrocephalus : a TMS study ' , Journal of Neural Transmission , vol. 126 , no. 8 , pp. 1073-1080 . https://doi.org/10.1007/s00702-019-02036-6Test; 06e00723-de21-4304-b004-144d3989714b; 85067840540; https://hdl.handle.net/20.500.11815/2981Test

الإتاحة: https://doi.org/20.500.11815/2981Test
https://doi.org/10.1007/s00702-019-02036-6Test
https://hdl.handle.net/20.500.11815/2981Test

المؤلفون: Hauer, Larissa, Sellner, Johann, Brigo, Francesco, Trinka, Eugen, Sebastianelli, Luca, Saltuari, Leopold, Versace, Viviana, Höller, Yvonne, Nardone, Raffaele

المساهمون: School of Humanities and Social Sciences

مصطلحات موضوعية: Depression, Geðklofi, Einhverfa, Taugavísindi, Attention, Autism, Dorsolateral prefrontal cortex, Repetitive transcranial magnetic stimulation, Schizophrenia, General Medicine

الوصف: Publisher Copyright: © 2019, MDPI AG. All rights reserved. ; Repetitive transcranial magnetic stimulation (rTMS) may be effective for enhancing cognitive functioning. In this review, we aimed to systematically evaluate the effects of rTMS on attention in psychiatric diseases. In particular, we searched PubMed and Embase to examine the effectiveness of rTMS administered to the dorsolateral prefrontal cortex (DLPFC) on this specific cognitive domain. The search identified 24 articles, 21 of which met inclusion and exclusion criteria. Among them, nine were conducted in patients with depression, four in patients with schizophrenia, three in patients with autism spectrum disorder (ASD), two in patients with attention deficit hyperactivity disorder, one each in patients with Alzheimer’s disease and in patients with alcohol or methamphetamine addiction. No evidence for cognitive adverse effects was found in all the included rTMS studies. Several studies showed a significant improvement of attentional function in patients with depression and schizophrenia. The beneficial effects on attention and other executive functions suggest that rTMS has the potential to target core features of ASD. rTMS may influence the attentional networks in alcohol-dependent and other addicted patients. We also reviewed and discussed the studies assessing the effects of rTMS on attention in the healthy population. This review suggests that prefrontal rTMS could exert procognitive effects on attention in patients with many psychiatric disorders. ; Peer reviewed

العلاقة: Journal of Clinical Medicine; 8(4); http://www.scopus.com/inward/record.url?scp=85087424278&partnerID=8YFLogxKTest; Hauer , L , Sellner , J , Brigo , F , Trinka , E , Sebastianelli , L , Saltuari , L , Versace , V , Höller , Y & Nardone , R 2019 , ' Effects of repetitive transcranial magnetic stimulation over prefrontal cortex on attention in psychiatric disorders : A systematic review ' , Journal of Clinical Medicine , vol. 8 , no. 4 , 416 . https://doi.org/10.3390/jcm8040416Test; 318a114e-fa64-49da-9d62-3dcae51bd766; 85087424278; https://hdl.handle.net/20.500.11815/3206Test

الإتاحة: https://doi.org/20.500.11815/3206Test
https://doi.org/10.3390/jcm8040416Test
https://hdl.handle.net/20.500.11815/3206Test