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Association of glial and neuronal degeneration markers with Alzheimer’s disease cerebrospinal fluid profile and cognitive functions

التفاصيل البيبلوغرافية
العنوان: Association of glial and neuronal degeneration markers with Alzheimer’s disease cerebrospinal fluid profile and cognitive functions
المؤلفون: Teitsdóttir, Unnur Diljá, Jónsdóttir, María K., Lund, Sigrún H., Darreh-Shori, Taher, Snædal, Jón, Petersen, Pétur H.
المساهمون: Læknadeild (HÍ), Faculty of Medicine (UI), Lífvísindasetur (HÍ), Biomedical Center (UI), Sálfræðideild (HR), Department of Psychology (RU), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Samfélagssvið (HR), School of Social Sciences (RU), Háskóli Íslands, University of Iceland, Háskólinn í Reykjavík, Reykjavik University
بيانات النشر: Springer Science and Business Media LLC
سنة النشر: 2020
المجموعة: Opin vísindi (Iceland)
مصطلحات موضوعية: AD biomarker profile, Alzheimer's disease, Cerebrospinal fluid, Cognitive domains, Glial fibrillary acidic protein, Neurofilament light, S100 calcium-binding protein B, YKL-40, Alzheimer sjúkdómur
الوصف: Publisher's version (útgefin grein) ; Background: Neuroinflammation has gained increasing attention as a potential contributing factor in the onset and progression of Alzheimer's disease (AD). The objective of this study was to examine the association of selected cerebrospinal fluid (CSF) inflammatory and neuronal degeneration markers with signature CSF AD profile and cognitive functions among subjects at the symptomatic pre- and early dementia stages. Methods: In this cross-sectional study, 52 subjects were selected from an Icelandic memory clinic cohort. Subjects were classified as having AD (n = 28, age = 70, 39% female, Mini-Mental State Examination [MMSE] = 27) or non-AD (n = 24, age = 67, 33% female, MMSE = 28) profile based on the ratio between CSF total-tau (T-tau) and amyloid-β1-42 (Aβ42) values (cut-off point chosen as 0.52). Novel CSF biomarkers included neurofilament light (NFL), YKL-40, S100 calcium-binding protein B (S100B) and glial fibrillary acidic protein (GFAP), measured with enzyme-linked immunosorbent assays (ELISAs). Subjects underwent neuropsychological assessment for evaluation of different cognitive domains, including verbal episodic memory, non-verbal episodic memory, language, processing speed, and executive functions. Results: Accuracy coefficient for distinguishing between the two CSF profiles was calculated for each CSF marker and test. Novel CSF markers performed poorly (area under curve [AUC] coefficients ranging from 0.61 to 0.64) compared to tests reflecting verbal episodic memory, which all performed fair (AUC > 70). LASSO regression with a stability approach was applied for the selection of CSF markers and demographic variables predicting performance on each cognitive domain, both among all subjects and only those with a CSF AD profile. Relationships between CSF markers and cognitive domains, where the CSF marker reached stability selection criteria of > 75%, were visualized with scatter plots. Before calculations of corresponding Pearson's correlations coefficients, ...
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 1758-9193
العلاقة: Alzheimer's Research & Therapy;12(1); https://alzres.biomedcentral.com/articles/10.1186/s13195-020-00657-8Test; Teitsdottir, U.D., Jonsdottir, M.K., Lund, S.H. et al. Association of glial and neuronal degeneration markers with Alzheimer’s disease cerebrospinal fluid profile and cognitive functions. Alzheimer's Research & Therapy 12, 92 (2020). https://doi.org/10.1186/s13195-020-00657-8Test; https://hdl.handle.net/20.500.11815/2260Test; Alzheimer's Research & Therapy
DOI: 10.1186/s13195-020-00657-8
الإتاحة: https://doi.org/20.500.11815/2260Test
https://doi.org/10.1186/s13195-020-00657-8Test
https://hdl.handle.net/20.500.11815/2260Test
حقوق: info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.374DD9B
قاعدة البيانات: BASE
الوصف
تدمد:17589193
DOI:10.1186/s13195-020-00657-8