دورية أكاديمية
Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity
| العنوان: | Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity |
|---|---|
| المؤلفون: | Cantuti-Castelvetri, Ludovico, Ojha, Ravi, Pedro, Liliana D., Djannatian, Minou, Franz, Jonas, Kuivanen, Suvi, Meer, Franziska van der, Kallio, Katri, Kaya, Tugberk, Anastasina, Maria, Smura, Teemu, Levanov, Lev, Szirovicza, Leonora, Tobi, Allan, Kallio-Kokko, Hannimari, Osterlund, Pamela, Joensuu, Merja, Meunier, Frederic A., Butcher, Sarah J., Winkler, Martin Sebastian, Mollenhauer, Brit, Helenius, Ari, Gokce, Ozgun, Teesalu, Tambet, Hepojoki, Jussi, Vapalahti, Olli, Stadelmann, Christine, Balistreri, Giuseppe, Simons, Mikael |
| المصدر: | Science |
| بيانات النشر: | Ludwig-Maximilians-Universität München |
| سنة النشر: | 2020 |
| المجموعة: | Open Access LMU (Ludwig-Maximilians-University Munich) |
| مصطلحات موضوعية: | Medizin, Munich Cluster for Systems Neurology (SyNergy), ddc:610 |
| الوصف: | The causative agent of coronavirus disease 2019 (COVID-19) is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For many viruses, tissue tropism is determined by the availability of virus receptors and entry cofactors on the surface of host cells. In this study, we found that neuropilin-1 (NRP1), known to bind furin-cleaved substrates, significantly potentiates SARS-CoV-2 infectivity, an effect blocked by a monoclonal blocking antibody against NRP1. A SARS-CoV-2 mutant with an altered furin cleavage site did not depend on NRP1 for infectivity. Pathological analysis of olfactory epithelium obtained from human COVID-19 autopsies revealed that SARS-CoV-2 infected NRP1-positive cells facing the nasal cavity. Our data provide insight into SARS-CoV-2 cell infectivity and define a potential target for antiviral intervention. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Cantuti-Castelvetri, Ludovico; Ojha, Ravi; Pedro, Liliana D.; Djannatian, Minou; Franz, Jonas; Kuivanen, Suvi; Meer, Franziska van der; Kallio, Katri; Kaya, Tugberk; Anastasina, Maria; Smura, Teemu; Levanov, Lev; Szirovicza, Leonora; Tobi, Allan; Kallio-Kokko, Hannimari; Osterlund, Pamela; Joensuu, Merja; Meunier, Frederic A.; Butcher, Sarah J.; Winkler, Martin Sebastian; Mollenhauer, Brit; Helenius, Ari; Gokce, Ozgun; Teesalu, Tambet; Hepojoki, Jussi; Vapalahti, Olli; Stadelmann, Christine; Balistreri, Giuseppe und Simons, Mikael (2020): Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. In: Science, Bd. 370, Nr. 6518: S. 856-860 [PDF, 1MB]; https://epub.ub.uni-muenchen.de/86754/1/science.abd2985.pdfTest; http://nbn-resolving.de/urn:nbn:de:bvb:19-epub-86754-8Test; https://epub.ub.uni-muenchen.de/86754Test/ |
| DOI: | 10.1126/science.abd2985 |
| الإتاحة: | https://doi.org/10.1126/science.abd2985Test https://epub.ub.uni-muenchen.de/86754/1/science.abd2985.pdfTest https://epub.ub.uni-muenchen.de/86754Test/ http://nbn-resolving.de/urn:nbn:de:bvb:19-epub-86754-8Test |
| رقم الانضمام: | edsbas.40D649D4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1126/science.abd2985 |
|---|