دورية أكاديمية
أعرض في EDS

Stroke genetics informs drug discovery and risk prediction across ancestries

التفاصيل البيبلوغرافية
العنوان: Stroke genetics informs drug discovery and risk prediction across ancestries
المؤلفون: Mishra, Aniket, Malik, Rainer, Hachiya, Tsuyoshi, Jürgenson, Tuuli, Namba, Shinichi, Posner, Daniel C., Kamanu, Frederick K., Koido, Masaru, Le Grand, Quentin, Shi, Mingyang, He, Yunye, Georgakis, Marios K., Caro, Ilana, Krebs, Kristi, Liaw, Yi-Ching, Vaura, Felix C., Lin, Kuang, Winsvold, Bendik Slagsvold, Srinivasasainagendra, Vinodh, Parodi, Livia, Bae, Hee-Joon, Chauhan, Ganesh, Chong, Michael R., Tomppo, Liisa, Akinyemi, Rufus, Roshchupkin, Gennady V., Habib, Naomi, Jee, Yon Ho, Thomassen, Jesper Qvist, Abedi, Vida, Carcel-Marquez, Jara, Nygaard, Marianne, Leonard, Hampton L., Yang, Chaojie, Yonova-Doing, Ekaterina, Knol, Maria J., Lewis, Adam J., Judy, Renae L., Ago, Tetsuro, Amouyel, Philippe, Armstrong, Nicole D., Bakker, Mark K., Bartz, Traci M., Bennett, David A., Bis, Joshua C., Bordes, Constance, Borte, Sigrid, Cain, Anael, Ridker, Paul M., Cho, Kelly, Chen, Zhengming, Cruchaga, Carlos, Cole, John W., Jager, Phil L. de, Cid, Rafael de, Endres, Matthias, Ferreira, Leslie E., Geerlings, Mirjam I., Gasca, Natalie C., Gudnason, Vilmundur, Hata, Jun, He, Jing, Heath, Alicia K., Ho, Yuk-Lam, Havulinna, Aki S., Hopewell, Jemma C., Hyacinth, Hyacinth I., Inouye, Michael, Jacob, Mina A., Jeon, Christina E., Jern, Christina, Kamouchi, Masahiro, Keene, Keith L., Kitazono, Takanari, Kittner, Steven J., Konuma, Takahiro, Kumar, Amit, Lacaze, Paul, Launer, Lenore J., Lee, Keon-Joo, Lepik, Kaido, Li, Jiang, Li, Liming, Manichaikul, Ani, Markus, Hugh S., Marston, Nicholas A., Meitinger, Thomas, Mitchell, Braxton D., Montellano, Felipe A., Morisaki, Takayuki, Mosley, Thomas H., Nalls, Mike A., Nordestgaard, Borge G., O'Donnell, Martin J., Okada, Yukinori, Onland-Moret, N. Charlotte, Ovbiagele, Bruce, Peters, Annette, Psaty, Bruce M., Rich, Stephen S., Rosand, Jonathan, Sabatine, Marc S., Sacco, Ralph L., Saleheen, Danish, Sandset, Else Charlotte, Salomaa, Veikko, Sargurupremraj, Muralidharan, Sasaki, Makoto, Satizabal, Claudia L., Schmidt, Carsten O., Shimizu, Atsushi, Smith, Nicholas L., Sloane, Kelly L., Sutoh, Yoichi, Sun, Yan V., Tanno, Kozo, Tiedt, Steffen, Tatlisumak, Turgut, Torres-Aguila, Nuria P., Tiwari, Hemant K., Tregouet, David-Alexandre, Trompet, Stella, Tuladhar, Anil Man, Tybjaerg-Hansen, Anne, Vugt, Marion van, Vibo, Riina, Verma, Shefali S., Wiggins, Kerri L., Wennberg, Patrik, Woo, Daniel, Wilson, Peter W. F., Xu, Huichun, Yang, Qiong, Yoon, Kyungheon, Lee, Jin-Moo, Cheng, Yu-Ching, Meschia, James F., Chen, Wei Min, Sale, Michele M., Zonderman, Alan B., Evans, Michele K., Wilson, James G., Correa, Adolfo, Traylor, Matthew, Lewis, Cathryn M., Carty, Cara L., Reiner, Alexander, Haessler, Jeffrey, Langefeld, Carl D., Gottesman, Rebecca F., Yaffe, Kristine, Liu, Yong Mei, Kooperberg, Charles, Lange, Leslie A., Furie, Karen L., Arnett, Donna K., Benavente, Oscar R., Grewal, Raji P., Peddareddygari, Leema Reddy, Hveem, Kristian, Lindstrom, Sara, Wang, Lu, Smith, Erin N., Gordon, William, Hylckama Vlieg, Astrid van, de Andrade, Mariza, Brody, Jennifer A., Pattee, Jack W., Brumpton, Ben M., Suchon, Pierre, Chen, Ming-Huei, Frazer, Kelly A., Turman, Constance, Germain, Marine, MacDonald, James, Braekkan, Sigrid K., Armasu, Sebastian M., Pankratz, Nathan, Jackson, Rebecca D., Nielsen, Jonas B., Giulianini, Franco, Puurunen, Marja K., Ibrahim, Manal, Heckbert, Susan R., Bammler, Theo K., McCauley, Bryan M., Taylor, Kent D., Pankow, James S., Reiner, Alexander P., Gabrielsen, Maiken E., Deleuze, Jean-Francois, O'Donnell, Chris J., Kim, Jihye, McKnight, Barbara, Kraft, Peter, Hansen, John-Bjarne, Rosendaal, Frits R., Heit, John A., Tang, Weihong, Morange, Pierre-Emmanuel, Johnson, Andrew D., Kabrhel, Christopher, Dijk, Ewoud J. van, Koudstaal, Peter J., Luijckx, Gert-Jan, Nederkoorn, Paul J., Oostenbrugge, Robert J. van, Visser, Marieke C., Wermer, Marieke J. H., Kappelle, L. Jaap, Esko, Tonu, Metspalu, Andres, Magi, Reedik, Nelis, Mari, Irvin, Marguerite R., de Leeuw, Frank-Erik, Levi, Christopher R., Maguire, Jane, Jimenez-Conde, Jordi, Sharma, Pankaj, Sudlow, Cathie L. M., Rannikmae, Kristiina, Schmidt, Reinhold, Slowik, Agnieszka, Pera, Joanna, Thijs, Vincent N. S., Lindgren, Arne G., Ilinca, Andreea, Melander, Olle, Engstrom, Gunnar, Rexrode, Kathryn M., Rothwell, Peter M., Stanne, Tara M., Johnson, Julie A., Danesh, John, Butterworth, Adam S., Heitsch, Laura, Boncoraglio, Giorgio B., Kubo, Michiaki, Pezzini, Alessandro, Rolfs, Arndt, Giese, Anne-Katrin, Weir, David, Ross, Owen A., Lemmons, Robin, Soderholm, Martin, Cushman, Mary, Jood, Katarina, McDonough, Caitrin W., Bell, Steven, Linkohr, Birgit, Lee, Tsong-Hai, Putaala, Jukka, Anderson, Christopher D., Lopez, Oscar L., Jian, Xueqiu, Schminke, Ulf, Cullell, Natalia, Delgado, Pilar, Ibanez, Laura, Krupinski, Jerzy, Lioutas, Vasileios, Matsuda, Koichi, Montaner, Joan, Muino, Elena, Roquer, Jaume, Sarnowski, Chloe, Sattar, Naveed, Sibolt, Gerli, Teumer, Alexander, Rutten-Jacobs, Loes, Kanai, Masahiro, Gretarsdottir, Solveig, Rost, Natalia S., Yusuf, Salim, Almgren, Peter, Ay, Hakan, Bevan, Steve, Brown, Robert D., Carrera, Caty, Buring, Julie E., Chen, Wei-Min, Cotlarciuc, Ioana, de Bakker, Paul I. W., DeStefano, Anita L., Hoed, Marcel den, Duan, Qing, Engelter, Stefan T., Falcone, Guido J., Gustafsson, Stefan, Hassan, Ahamad, Holliday, Elizabeth G., Howard, George, Hsu, Fang-Chi, Ingelsson, Erik, Harris, Tamara B., Kissela, Brett M., Kleindorfer, Dawn O., Langenberg, Claudia, Lemmens, Robin, Leys, Didier, Lin, Wei-Yu, Lorentzen, Erik, Magnusson, Patrik K., McArdle, Patrick F., Pulit, Sara L., Rice, Kenneth, Sakaue, Saori, Sapkota, Bishwa R., Tanislav, Christian, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tzourio, Christophe, Duijn, Cornelia M. van, Walters, Matthew, Wareham, Nicholas J., Amin, Najaf, Aparicio, Hugo J., Attia, John, Beiser, Alexa S., Berr, Claudine, Bustamante, Mariana, Caso, Valeria, Choi, Seung Hoan, Chowhan, Ayesha, Dartigues, Jean-Francois, Delavaran, Hossein, Dorr, Marcus, Ford, Ian, Gurpreet, Wander S., Hamsten, Anders, Hozawa, Atsushi, Ingelsson, Martin, Iwasaki, Motoki, Kaffashian, Sara, Kalra, Lalit, Kjartansson, Olafur, Kloss, Manja, Labovitz, Daniel L., Laurie, Cathy C., Li, Linxin, Lind, Lars, Lindgren, Cecilia M., Makoto, Hirata, Minegishi, Naoko, Morris, Andrew P., Müller-Nurasyid, Martina, Norrving, Bo, Ogishima, Soichi, Parati, Eugenio A., Pedersen, Nancy L., Perola, Markus, Jousilahti, Pekka, Pileggi, Silvana, Rabionet, Raquel, Riba-Llena, Iolanda, Ribases, Marta, Romero, Jose R., Rudd, Anthony G., Sarin, Antti-Pekka, Sarju, Ralhan, Satoh, Mamoru, Sawada, Norie, Sigurdsson, Asgeir, Smith, Albert, Stine, O. Colin, Stott, David J., Strauch, Konstantin, Takai, Takako, Tanaka, Hideo, Touze, Emmanuel, Tsugane, Shoichiro, Uitterlinden, Andre G., Valdimarsson, Einar M., Lee, Sven J. van der, Wakai, Kenji, Williams, Stephen R., Wolfe, Charles D. A., Wong, Quenna, Yamaji, Taiki, Sanghera, Dharambir K., Stefansson, Kari, Martinez-Majander, Nicolas, Sobue, Kenji, Soriano-Tarraga, Carolina, Volzke, Henry, Akpa, Onoja, Sarfo, Fred S., Akpalu, Albert, Obiako, Reginald, Wahab, Kolawole, Osaigbovo, Godwin, Owolabi, Lukman, Komolafe, Morenikeji, Jenkins, Carolyn, Arulogun, Oyedunni, Ogbole, Godwin, Adeoye, Abiodun M., Akinyemi, Joshua, Agunloye, Atinuke, Fakunle, Adekunle G., Uvere, Ezinne, Olalere, Abimbola, Adebajo, Olayinka J., Chen, Junshi, Clarke, Robert, Collins, Rory, Guo, Yu, Wang, Chen, Lv, Jun, Peto, Richard, Chen, Yiping, Fairhurst-Hunter, Zammy, Hill, Michael, Pozarickij, Alfred, Schmidt, Dan, Stevens, Becky, Turnbull, Iain, Yu, Canqing, Nagai, Akiko, Murakami, Yoishinori, Shiroma, Eric J., Sigurdsson, Sigurdur, Ghanbari, Mohsen, Boerwinkle, Eric, Fongang, Bernard, Wang, Ruiqi, Ikram, Mohammad K., Volker, Uwe, de Jager, Phil L., de Cid, Rafael, de Laat, Karlijn F., Norden, Anouk G. W. van, de Kort, Paul L., Vermeer, Sarah E., Brouwers, Paul J. A. M., Gons, Rob A. R., den Heijer, Tom, Dijk, Gert W. van, Rooij, Frank G. W. van, Aamodt, Anne H., Skogholt, Anne H., Willer, Cristen J., Heuch, Ingrid, Hagen, Knut, Fritsche, Lars G., Pedersen, Linda M., Ellekjaer, Hanne, Zhou, Wei, Martinsen, Amy E., Kristoffersen, Espen S., Thomas, Laurent F., Kleinschnitz, Christoph, Frantz, Stefan, Ungethum, Kathrin, Gallego-Fabrega, Cristina, Lledos, Miquel, Llucia-Carol, Laia, Sobrino, Tomas, Campos, Francisco, Castillo, Jose, Freijo, Marimar, Arenillas, Juan Francisco, Obach, Victor, Alvarez-Sabin, Jose, Molina, Carlos A., Ribo, Marc, Munoz-Narbona, Lucia, Lopez-Cancio, Elena, Millan, Monica, Diaz-Navarro, Rosa, Vives-Bauza, Cristofol, Serrano-Heras, Gemma, Segura, Tomas, Dhar, Rajat, Delgado-Mederos, Raquel, Prats-Sanchez, Luis, Camps-Renom, Pol, Blay, Natalia, Sumoy, Lauro, Marti-Fabregas, Joan, Schnohr, Peter, Jensen, Gorm B., Benn, Marianne, Afzal, Shoaib, Kamstrup, Pia R., Setten, Jessica van, Laan, Sander W. van der, Vonk, Jet M. J., Kim, Bong-Jo, Curtze, Sami, Tiainen, Marjaana, Kinnunen, Janne, Menon, Vilas, Sung, Yun Ju, Yang, Chengran, Saillour-Glenisson, Florence, Gravel, Simon, Millwood, Iona Y., Gieger, Christian, Ninomiya, Toshiharu, Grabe, Hans J., Jukema, J. Wouter, Rissanen, Ina L., Strbian, Daniel, Kim, Young Jin, Chen, Pei-Hsin, Mayerhofer, Ernst, Howson, Joanna M. M., Adams, Hieab, Wassertheil-Smoller, Sylvia, Christensen, Kaare, Ikram, Mohammad A., Rundek, Tatjana, Worrall, Bradford B., Lathrop, G. Mark, Riaz, Moeen, Simonsick, Eleanor M., Korv, Janika, Franca, Paulo H. C., Zand, Ramin, Prasad, Kameshwar, Frikke-Schmidt, Ruth, Liman, Thomas, Haeusler, Karl Georg, Ruigrok, Ynte M., Heuschmann, Peter Ulrich, Longstreth, W. T., Jung, Keum Ji, Bastarache, Lisa, Pare, Guillaume, Damrauer, Scott M., Chasman, Daniel I., Rotter, Jerome I., Zwart, John-Anker, Niiranen, Teemu J., Fornage, Myriam, Liaw, Yung-Po, Seshadri, Sudha, Fernandez-Cadenas, Israel, Walters, Robin G., Ruff, Christian T., Owolabi, Mayowa O., Huffman, Jennifer E., Milani, Lili, Kamatani, Yoichiro
المصدر: Nature
بيانات النشر: Ludwig-Maximilians-Universität München
سنة النشر: 2022
المجموعة: Open Access LMU (Ludwig-Maximilians-University Munich)
مصطلحات موضوعية: Medizin, Munich Cluster for Systems Neurology (SyNergy), ddc:610
الوصف: Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry(1,2). Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis(3), and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach(4), we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry(5). Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
العلاقة: Mishra, Aniket; Malik, Rainer; Hachiya, Tsuyoshi; Jürgenson, Tuuli; Namba, Shinichi; Posner, Daniel C.; Kamanu, Frederick K.; Koido, Masaru; Le Grand, Quentin; Shi, Mingyang; He, Yunye; Georgakis, Marios K.; Caro, Ilana; Krebs, Kristi; Liaw, Yi-Ching; Vaura, Felix C.; Lin, Kuang; Winsvold, Bendik Slagsvold; Srinivasasainagendra, Vinodh; Parodi, Livia; Bae, Hee-Joon; Chauhan, Ganesh; Chong, Michael R.; Tomppo, Liisa; Akinyemi, Rufus; Roshchupkin, Gennady V.; Habib, Naomi; Jee, Yon Ho; Thomassen, Jesper Qvist; Abedi, Vida; Carcel-Marquez, Jara; Nygaard, Marianne; Leonard, Hampton L.; Yang, Chaojie; Yonova-Doing, Ekaterina; Knol, Maria J.; Lewis, Adam J.; Judy, Renae L.; Ago, Tetsuro; Amouyel, Philippe; Armstrong, Nicole D.; Bakker, Mark K.; Bartz, Traci M.; Bennett, David A.; Bis, Joshua C.; Bordes, Constance; Borte, Sigrid; Cain, Anael; Ridker, Paul M.; Cho, Kelly; Chen, Zhengming; Cruchaga, Carlos; Cole, John W.; Jager, Phil L. de; Cid, Rafael de; Endres, Matthias; Ferreira, Leslie E.; Geerlings, Mirjam I.; Gasca, Natalie C.; Gudnason, Vilmundur; Hata, Jun; He, Jing; Heath, Alicia K.; Ho, Yuk-Lam; Havulinna, Aki S.; Hopewell, Jemma C.; Hyacinth, Hyacinth I.; Inouye, Michael; Jacob, Mina A.; Jeon, Christina E.; Jern, Christina; Kamouchi, Masahiro; Keene, Keith L.; Kitazono, Takanari; Kittner, Steven J.; Konuma, Takahiro; Kumar, Amit; Lacaze, Paul; Launer, Lenore J.; Lee, Keon-Joo; Lepik, Kaido; Li, Jiang; Li, Liming; Manichaikul, Ani; Markus, Hugh S.; Marston, Nicholas A.; Meitinger, Thomas; Mitchell, Braxton D.; Montellano, Felipe A.; Morisaki, Takayuki; Mosley, Thomas H.; Nalls, Mike A.; Nordestgaard, Borge G.; O'Donnell, Martin J.; Okada, Yukinori; Onland-Moret, N. Charlotte; Ovbiagele, Bruce; Peters, Annette; Psaty, Bruce M.; Rich, Stephen S.; Rosand, Jonathan; Sabatine, Marc S.; Sacco, Ralph L.; Saleheen, Danish; Sandset, Else Charlotte; Salomaa, Veikko; Sargurupremraj, Muralidharan; Sasaki, Makoto; Satizabal, Claudia L.; Schmidt, Carsten O.; Shimizu, Atsushi; Smith, Nicholas L.; Sloane, Kelly L.; Sutoh, Yoichi; Sun, Yan V.; Tanno, Kozo; Tiedt, Steffen; Tatlisumak, Turgut; Torres-Aguila, Nuria P.; Tiwari, Hemant K.; Tregouet, David-Alexandre; Trompet, Stella; Tuladhar, Anil Man; Tybjaerg-Hansen, Anne; Vugt, Marion van; Vibo, Riina; Verma, Shefali S.; Wiggins, Kerri L.; Wennberg, Patrik; Woo, Daniel; Wilson, Peter W. F.; Xu, Huichun; Yang, Qiong; Yoon, Kyungheon; Bis, Joshua C.; Bis, Joshua C.; Lee, Jin-Moo; Cheng, Yu-Ching; Meschia, James F.; Chen, Wei Min; Sale, Michele M.; Zonderman, Alan B.; Evans, Michele K.; Wilson, James G.; Correa, Adolfo; Traylor, Matthew; Lewis, Cathryn M.; Carty, Cara L.; Reiner, Alexander; Haessler, Jeffrey; Langefeld, Carl D.; Gottesman, Rebecca F.; Yaffe, Kristine; Liu, Yong Mei; Kooperberg, Charles; Lange, Leslie A.; Furie, Karen L.; Arnett, Donna K.; Benavente, Oscar R.; Grewal, Raji P.; Peddareddygari, Leema Reddy; Kooperberg, Charles; Kooperberg, Charles; Hveem, Kristian; Lindstrom, Sara; Wang, Lu; Smith, Erin N.; Gordon, William; Hylckama Vlieg, Astrid van; de Andrade, Mariza; Brody, Jennifer A.; Pattee, Jack W.; Haessler, Jeffrey; Brumpton, Ben M.; Suchon, Pierre; Chen, Ming-Huei; Frazer, Kelly A.; Turman, Constance; Germain, Marine; MacDonald, James; Braekkan, Sigrid K.; Armasu, Sebastian M.; Pankratz, Nathan; Jackson, Rebecca D.; Nielsen, Jonas B.; Giulianini, Franco; Puurunen, Marja K.; Ibrahim, Manal; Heckbert, Susan R.; Bammler, Theo K.; McCauley, Bryan M.; Taylor, Kent D.; Pankow, James S.; Reiner, Alexander P.; Gabrielsen, Maiken E.; Deleuze, Jean-Francois; O'Donnell, Chris J.; Kim, Jihye; McKnight, Barbara; Kraft, Peter; Hansen, John-Bjarne; Rosendaal, Frits R.; Heit, John A.; Tang, Weihong; Morange, Pierre-Emmanuel; Johnson, Andrew D.; Kabrhel, Christopher; Dijk, Ewoud J. van; Dijk, Ewoud J. van; Koudstaal, Peter J.; Luijckx, Gert-Jan; Nederkoorn, Paul J.; Oostenbrugge, Robert J. van; Visser, Marieke C.; Wermer, Marieke J. H.; Kappelle, L. Jaap; Esko, Tonu; Esko, Tonu; Metspalu, Andres; Magi, Reedik; Nelis, Mari; Irvin, Marguerite R.; Irvin, Marguerite R.; de Leeuw, Frank-Erik; Levi, Christopher R.; Maguire, Jane; Jimenez-Conde, Jordi; Sharma, Pankaj; Sudlow, Cathie L. M.; Rannikmae, Kristiina; Schmidt, Reinhold; Slowik, Agnieszka; Pera, Joanna; Thijs, Vincent N. S.; Lindgren, Arne G.; Ilinca, Andreea; Melander, Olle; Engstrom, Gunnar; Rexrode, Kathryn M.; Rothwell, Peter M.; Stanne, Tara M.; Johnson, Julie A.; Danesh, John; Butterworth, Adam S.; Heitsch, Laura; Boncoraglio, Giorgio B.; Kubo, Michiaki; Pezzini, Alessandro; Rolfs, Arndt; Giese, Anne-Katrin; Weir, David; Jackson, Rebecca D.; Ross, Owen A.; Lemmons, Robin; Soderholm, Martin; Cushman, Mary; Jood, Katarina; McDonough, Caitrin W.; Bell, Steven; Linkohr, Birgit; Lee, Tsong-Hai; Putaala, Jukka; Anderson, Christopher D.; Anderson, Christopher D.; Lopez, Oscar L.; Jian, Xueqiu; Schminke, Ulf; Cullell, Natalia; Delgado, Pilar; Ibanez, Laura; Krupinski, Jerzy; Lioutas, Vasileios; Matsuda, Koichi; Montaner, Joan; Muino, Elena; Roquer, Jaume; Sarnowski, Chloe; Sattar, Naveed; Sibolt, Gerli; Teumer, Alexander; Rutten-Jacobs, Loes; Kanai, Masahiro; Giese, Anne-Katrin; Gretarsdottir, Solveig; Rost, Natalia S.; Yusuf, Salim; Almgren, Peter; Ay, Hakan; Bevan, Steve; Brown, Robert D.; Carrera, Caty; Buring, Julie E.; Chen, Wei-Min; Cotlarciuc, Ioana; de Bakker, Paul I. W.; DeStefano, Anita L.; Hoed, Marcel den; Duan, Qing; Engelter, Stefan T.; Falcone, Guido J.; Gottesman, Rebecca F.; Gustafsson, Stefan; Hassan, Ahamad; Holliday, Elizabeth G.; Howard, George; Hsu, Fang-Chi; Ingelsson, Erik; Harris, Tamara B.; Kissela, Brett M.; Kleindorfer, Dawn O.; Langenberg, Claudia; Lemmens, Robin; Leys, Didier; Lin, Wei-Yu; Lorentzen, Erik; Magnusson, Patrik K.; McArdle, Patrick F.; Pulit, Sara L.; Rice, Kenneth; Sakaue, Saori; Sapkota, Bishwa R.; Tanislav, Christian; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Tzourio, Christophe; Duijn, Cornelia M. van; Walters, Matthew; Wareham, Nicholas J.; Amin, Najaf; Aparicio, Hugo J.; Attia, John; Beiser, Alexa S.; Berr, Claudine; Bustamante, Mariana; Caso, Valeria; Choi, Seung Hoan; Chowhan, Ayesha; Dartigues, Jean-Francois; Delavaran, Hossein; Dorr, Marcus; Ford, Ian; Gurpreet, Wander S.; Hamsten, Anders; Hozawa, Atsushi; Ingelsson, Martin; Iwasaki, Motoki; Kaffashian, Sara; Kalra, Lalit; Kjartansson, Olafur; Kloss, Manja; Labovitz, Daniel L.; Laurie, Cathy C.; Li, Linxin; Lind, Lars; Lindgren, Cecilia M.; Makoto, Hirata; Minegishi, Naoko; Morris, Andrew P.; Müller-Nurasyid, Martina; Norrving, Bo; Ogishima, Soichi; Parati, Eugenio A.; Pedersen, Nancy L.; Perola, Markus; Jousilahti, Pekka; Pileggi, Silvana; Rabionet, Raquel; Riba-Llena, Iolanda; Ribases, Marta; Romero, Jose R.; Rudd, Anthony G.; Sarin, Antti-Pekka; Sarju, Ralhan; Satoh, Mamoru; Sawada, Norie; Sigurdsson, Asgeir; Smith, Albert; Stine, O. Colin; Stott, David J.; Strauch, Konstantin; Takai, Takako; Tanaka, Hideo; Touze, Emmanuel; Tsugane, Shoichiro; Uitterlinden, Andre G.; Valdimarsson, Einar M.; Lee, Sven J. van der; Wakai, Kenji; Williams, Stephen R.; Wolfe, Charles D. A.; Wong, Quenna; Yamaji, Taiki; Sanghera, Dharambir K.; Stefansson, Kari; Taylor, Kent D.; Martinez-Majander, Nicolas; Sobue, Kenji; Soriano-Tarraga, Carolina; Volzke, Henry; Akpa, Onoja; Akpa, Onoja; Sarfo, Fred S.; Akpalu, Albert; Obiako, Reginald; Wahab, Kolawole; Osaigbovo, Godwin; Owolabi, Lukman; Komolafe, Morenikeji; Jenkins, Carolyn; Arulogun, Oyedunni; Ogbole, Godwin; Adeoye, Abiodun M.; Akinyemi, Joshua; Agunloye, Atinuke; Fakunle, Adekunle G.; Uvere, Ezinne; Olalere, Abimbola; Adebajo, Olayinka J.; Chen, Junshi; Chen, Junshi; Clarke, Robert; Collins, Rory; Guo, Yu; Wang, Chen; Lv, Jun; Peto, Richard; Chen, Yiping; Fairhurst-Hunter, Zammy; Hill, Michael; Pozarickij, Alfred; Schmidt, Dan; Stevens, Becky; Turnbull, Iain; Yu, Canqing; Le Grand, Quentin; Le Grand, Quentin; Ferreira, Leslie E.; Nagai, Akiko; Nagai, Akiko; Murakami, Yoishinori; Geerlings, Mirjam I.; Geerlings, Mirjam I.; Gasca, Natalie C.; Gudnason, Vilmundur; Vugt, Marion van; Gottesman, Rebecca F.; Shiroma, Eric J.; Sigurdsson, Sigurdur; Ghanbari, Mohsen; Boerwinkle, Eric; Beiser, Alexa S.; Fongang, Bernard; Wang, Ruiqi; Ikram, Mohammad K.; Volker, Uwe; de Jager, Phil L.; de Jager, Phil L.; de Cid, Rafael; Nordestgaard, Borge G.; Sargurupremraj, Muralidharan; Verma, Shefali S.; de Laat, Karlijn F.; de Laat, Karlijn F.; Norden, Anouk G. W. van; de Kort, Paul L.; Vermeer, Sarah E.; Brouwers, Paul J. A. M.; Gons, Rob A. R.; Nederkoorn, Paul J.; den Heijer, Tom; Dijk, Gert W. van; Rooij, Frank G. W. van; Aamodt, Anne H.; Aamodt, Anne H.; Skogholt, Anne H.; Brumpton, Ben M.; Willer, Cristen J.; Heuch, Ingrid; Hagen, Knut; Fritsche, Lars G.; Pedersen, Linda M.; Gabrielsen, Maiken E.; Ellekjaer, Hanne; Zhou, Wei; Martinsen, Amy E.; Kristoffersen, Espen S.; Nielsen, Jonas B.; Hveem, Kristian; Thomas, Laurent F.; Kleinschnitz, Christoph; Kleinschnitz, Christoph; Frantz, Stefan; Ungethum, Kathrin; Gallego-Fabrega, Cristina; Gallego-Fabrega, Cristina; Lledos, Miquel; Llucia-Carol, Laia; Sobrino, Tomas; Campos, Francisco; Castillo, Jose; Freijo, Marimar; Arenillas, Juan Francisco; Obach, Victor; Alvarez-Sabin, Jose; Molina, Carlos A.; Ribo, Marc; Munoz-Narbona, Lucia; Lopez-Cancio, Elena; Millan, Monica; Diaz-Navarro, Rosa; Vives-Bauza, Cristofol; Serrano-Heras, Gemma; Segura, Tomas; Delgado, Pilar; Dhar, Rajat; Delgado-Mederos, Raquel; Prats-Sanchez, Luis; Camps-Renom, Pol; Blay, Natalia; Sumoy, Lauro; Marti-Fabregas, Joan; Schnohr, Peter; Schnohr, Peter; Jensen, Gorm B.; Benn, Marianne; Afzal, Shoaib; Kamstrup, Pia R.; Setten, Jessica van; Laan, Sander W. van der; Vonk, Jet M. 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T.; Jung, Keum Ji; Bastarache, Lisa; Pare, Guillaume; Damrauer, Scott M.; Chasman, Daniel I.; Rotter, Jerome I.; Anderson, Christopher D.; Zwart, John-Anker; Niiranen, Teemu J.; Fornage, Myriam; Liaw, Yung-Po; Seshadri, Sudha; Fernandez-Cadenas, Israel; Walters, Robin G.; Ruff, Christian T.; Owolabi, Mayowa O.; Huffman, Jennifer E.; Milani, Lili und Kamatani, Yoichiro (2022): Stroke genetics informs drug discovery and risk prediction across ancestries. In: Nature, Bd. 611, Nr. 7934: S. 115-123 [PDF, 16MB]; https://epub.ub.uni-muenchen.de/112654/1/s41586-022-05165-3.pdfTest; http://nbn-resolving.de/urn:nbn:de:bvb:19-epub-112654-0Test; https://epub.ub.uni-muenchen.de/112654Test/
DOI: 10.1038/s41586-022-05165-3
الإتاحة: https://doi.org/10.1038/s41586-022-05165-3Test
https://epub.ub.uni-muenchen.de/112654/1/s41586-022-05165-3.pdfTest
https://epub.ub.uni-muenchen.de/112654Test/
http://nbn-resolving.de/urn:nbn:de:bvb:19-epub-112654-0Test
رقم الانضمام: edsbas.CBE4294E
قاعدة البيانات: BASE
الوصف
DOI:10.1038/s41586-022-05165-3