دورية أكاديمية
Exposure to repetitive head impacts is associated with corpus callosum microstructure and plasma total tau in former professional american football players
| العنوان: | Exposure to repetitive head impacts is associated with corpus callosum microstructure and plasma total tau in former professional american football players |
|---|---|
| المؤلفون: | Kochsiek, Janna, O'Donnell, Lauren J., Zhang, Fan, Bonke, Elena M., Sollmann, Nico, Tripodis, Yorghos, Wiegand, Tim L. T., Kaufmann, David, Umminger, Lisa, Di Biase, Maria A., Kaufmann, Elisabeth, Schultz, Vivian, Alosco, Michael L., Martin, Brett M., Lin, Alexander P., Coleman, Michael J., Rathi, Yogesh, Pasternak, Ofer, Bouix, Sylvain, Stern, Robert A., Shenton, Martha E., Koerte, Inga K. |
| بيانات النشر: | Universität Ulm |
| سنة النشر: | 2022 |
| المجموعة: | OPARU (OPen Access Repository of Ulm University) |
| مصطلحات موضوعية: | Sport‐related brain injury, diffusion MR imaging, tractography, neurodegeneration, neuropsychological testing, DDC 610 / Medicine & health, Brain Injuries, Sports medicine, Athletic injuries, Chronic traumatic encephalopathy, Diffusion magnetic resonance imaging, Neuropsychological tests, Schädel-Hirn-Trauma, Sportverletzung, Nervendegeneration, Diffusionsgewichtete Magnetresonanztomografie, Neuropsychologischer Test |
| الوصف: | Background Exposure to repetitive head impacts (RHI) is associated with an increased risk of later‐life neurobehavioral dysregulation and neurodegenerative disease. The underlying pathomechanisms are largely unknown. Purpose To investigate whether RHI exposure is associated with later‐life corpus callosum (CC) microstructure and whether CC microstructure is associated with plasma total tau and neuropsychological/neuropsychiatric functioning. Study Type Retrospective cohort study. Population Seventy‐five former professional American football players (age 55.2 ± 8.0 years) with cognitive, behavioral, and mood symptoms. Field Strength/Sequence Diffusion‐weighted echo‐planar MRI at 3 T. Assessment Subjects underwent diffusion MRI, venous puncture, neuropsychological testing, and completed self‐report measures of neurobehavioral dysregulation. RHI exposure was assessed using the Cumulative Head Impact Index (CHII). Diffusion MRI measures of CC microstructure (i.e., free‐water corrected fractional anisotropy (FA), trace, radial diffusivity (RD), and axial diffusivity (AD)) were extracted from seven segments of the CC (CC1‐7), using a tractography clustering algorithm. Neuropsychological tests were selected: Trail Making Test Part A (TMT‐A) and Part B (TMT‐B), Controlled Oral Word Association Test (COWAT), Stroop Interference Test, and the Behavioral Regulation Index (BRI) from the Behavior Rating Inventory of Executive Function, Adult version (BRIEF‐A). Statistical Tests Diffusion MRI metrics were tested for associations with RHI exposure, plasma total tau, neuropsychological performance, and neurobehavioral dysregulation using generalized linear models for repeated measures. Results RHI exposure was associated with increased AD of CC1 (correlation coefficient (r) = 0.32, P < 0.05) and with increased plasma total tau (r = 0.34, P < 0.05). AD of the anterior CC1 was associated with increased plasma total tau (CC1: r = 0.30, P < 0.05; CC2: r = 0.29, P < 0.05). Higher trace, AD, and RD of CC1 were associated ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fjmri.27774&file=jmri27774-sup-0001-FigureS1.tifTest; http://dx.doi.org/10.18725/OPARU-44169Test; https://oparu.uni-ulm.de/xmlui/123456789/44245Test; http://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-44245-5Test |
| DOI: | 10.18725/OPARU-44169 |
| الإتاحة: | https://doi.org/10.18725/OPARU-44169Test https://oparu.uni-ulm.de/xmlui/123456789/44245Test http://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-44245-5Test |
| حقوق: | CC BY 4.0 International ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.59B781BE |
| قاعدة البيانات: | BASE |
| DOI: | 10.18725/OPARU-44169 |
|---|