رسالة جامعية
ATP, HMGB1, and S100A4 promote immunosuppressive mesenchymal stromal cells by enhancing their kynurenine production : impact of necrosis on tumor-associated MSCs
| العنوان: | ATP, HMGB1, and S100A4 promote immunosuppressive mesenchymal stromal cells by enhancing their kynurenine production : impact of necrosis on tumor-associated MSCs |
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| المؤلفون: | Hang, Regina |
| المساهمون: | Lotfi, Ramin, Jahrsdörfer, Bernd |
| بيانات النشر: | Universität Ulm |
| سنة النشر: | 2019 |
| المجموعة: | OPARU (OPen Access Repository of Ulm University) |
| مصطلحات موضوعية: | DAMPs, HMGB1, S100A4, Indoleamine dioxygenase, DDC 610 / Medicine & health, Mesenchymal stem cells, Necrosis, Dioxygenases, Kynurenine, Neoplasms, Immunology, HMGB proteins, S100 calcium-binding protein A4, Adenosine triphosphate, Mesenchymzelle, Nekrose, Kynurenin, Tumor, ATP, Calcium-bindende Proteine |
| الوصف: | Mesenchymal stromal cells (MSCs) are known to act as immunosuppressive cells, partially due to the expression of the enzyme indoleamine dioxygenase (IDO), which converts tryptophan to kynurenine. Accumulation of MSCs within tumor tissue is associated with tumor progression and poor prognosis. Necrotic cell death with subsequent release of damage associated molecular patterns (DAMPs) is a characteristic feature of advanced solid tumors. Adenosine triphosphate (ATP), high mobility box 1 (HMGB1), S100A4 and uric acid belong to known DAMPs family members. It was already shown that DAMPs act as chemoattractants on MSCs, also influencing their proliferation. The present work aims at determining if DAMPs have any impact on immunosuppressive capacities of MSCs, with specific regard to IDO-activity and subsequent production of kynurenine. |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| وصف الملف: | application/pdf |
| اللغة: | English |
| ردمك: | 978-1-66535-947-4 1-66535-947-1 |
| العلاقة: | http://dx.doi.org/10.18725/OPARU-14033Test; https://oparu.uni-ulm.de/xmlui/123456789/14090Test; http://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-14090-7Test |
| DOI: | 10.18725/OPARU-14033 |
| الإتاحة: | https://doi.org/10.18725/OPARU-14033Test https://oparu.uni-ulm.de/xmlui/123456789/14090Test http://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-14090-7Test |
| حقوق: | Standard |
| رقم الانضمام: | edsbas.57175062 |
| قاعدة البيانات: | BASE |
| ردمك: | 9781665359474 1665359471 |
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| DOI: | 10.18725/OPARU-14033 |