دورية أكاديمية
The spectrum and differential diagnosis of acquired ocular motor nerve palsies : a clinical study of 502 patients
| العنوان: | The spectrum and differential diagnosis of acquired ocular motor nerve palsies : a clinical study of 502 patients |
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| المؤلفون: | Hörner, Rebecca, Kassubek, Jan, Dreyhaupt, Jens, Ludolph, Albert C. |
| بيانات النشر: | Universität Ulm |
| سنة النشر: | 2023 |
| المجموعة: | OPARU (OPen Access Repository of Ulm University) |
| مصطلحات موضوعية: | Cranial nerve palsy, Ocular motor nerve, DDC 610 / Medicine & health, Cranial nerve diseases, Trochlear nerve, Abducens nerve, Magnetic resonance imaging, Cerebrospinal fluid, Hirnnervenkrankheit, Abduzenslähmung, Kernspintomografie, Liquor cerebrospinalis |
| الوصف: | Background Ocular motor nerve palsies (OMNP) frequently cause patients to present in an emergency room. In the following study, we report the differential diagnosis of OMNP by use of magnetic resonance imaging (MRI) and CSF examination as a standard. Method We performed a data analysis of N = 502 patients who presented with oculomotor, trochlear, and/or abducens nerve palsy in the emergency room of the Department of Neurology, University of Ulm, between January 2006 and December 2019. We report clinical and MRI scan findings in all patients; furthermore, the CSF of 398 patients has been analysed. Results Abducens nerve palsies were most common (45%), followed by palsies of the oculomotor (31%) (CNP III) and trochlear nerve (15%). Multiple OMNPs were seen in 9% of our cohort. The most common causes included inflammations (32.7%), space-occupying lesions, such as aneurysms or neoplasms (17.3%), diabetes mellitus (13.3%), and brainstem infarctions (11%). Still 23.4% of the patients could not be assigned to any specific cause after differential diagnostic procedures and were described as idiopathic. One of three patients with an inflammation and 39% of the patients with space-occupying lesions showed additional cranial nerve deficits. Conclusion Inflammation and space-occupying processes were the most frequent causes of OMNP, although brainstem infarctions also play a significant role, in particular in CNP III. The presence of additional CNPs increases the probability of an inflammatory or space-occupying cause. ; publishedVersion |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | http://dx.doi.org/10.18725/OPARU-49745Test; https://oparu.uni-ulm.de/xmlui/123456789/49821Test; http://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-49821-7Test |
| DOI: | 10.18725/OPARU-49745 |
| الإتاحة: | https://doi.org/10.18725/OPARU-49745Test https://oparu.uni-ulm.de/xmlui/123456789/49821Test http://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-49821-7Test |
| حقوق: | CC BY 4.0 International ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.F77DBF2A |
| قاعدة البيانات: | BASE |
| DOI: | 10.18725/OPARU-49745 |
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