دورية أكاديمية
Clinical and microbiological characteristics of polymicrobial bacteremia: a retrospective, multicenter study
| العنوان: | Clinical and microbiological characteristics of polymicrobial bacteremia: a retrospective, multicenter study |
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| المؤلفون: | Fukushima, Shinnosuke, Hagiya, Hideharu, Fujita, Koji, Kamiyama, Shinya, Yamada, Haruto, Kishida, Masayuki, Otsuka, Fumio |
| المصدر: | Infection |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2022 |
| المجموعة: | Okayama University Scientific Achievement Repository / 岡山大学学術成果リポジトリ |
| مصطلحات موضوعية: | bloodstream infection, infectious focus, intra-abdominal infection, polymicrobial bacteremia, prognosis, risk factors |
| الوصف: | Purpose To clarify the clinical and microbial characteristics of polymicrobial bacteremia (PMB) to contribute to improvements in clinical diagnosis and effective early treatment. Methods This retrospective multicenter study used data from three acute-care hospitals in Okayama Prefecture, Japan, collected between January 2014 and March 2019. We reviewed the demographics, comorbidities, organisms isolated, infectious focus, and 30-day mortality of patients with PMB. Results Of the 7233 positive blood cultures, 808 (11.2%) were positive for more than one organism. Of the patients with bacteremia, 507 (7.0%) had PMB, of whom 65.3% were male. Infectious foci were identified in 78.3% of the cases, of which intra-abdominal infections accounted for 47.1%. A combination of Gram-positive cocci (GPC) (chain form) and Gram-negative rods (GNR) accounted for 32.9% of the cases, and GPC/GNR and GNR/GNR patterns were significantly associated with intra-abdominal infections. The 30-day mortality rate of patients with PMB was 18.1%, with a median of 7.5 days from diagnosis to death. The mortality in patients with an infectious focus identified was significantly lower than that in patients with an unknown focus (16.3% vs. 24.5%; p = 0.031). Conclusions Intra-abdominal infections were the most common source of PMB, and were strongly associated with a Gram-staining combination pattern of GPC (chain form)/GNR. PMB cases with an unknown focus had a poorer prognosis, highlighting the importance of early diagnosis and appropriate treatment. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0300-8126 |
| العلاقة: | info:pmid/35301683; https://ousar.lib.okayama-u.ac.jp/files/public/6/63366/20220413145719177939/fulltext20220413-1.pdfTest; https://ousar.lib.okayama-u.ac.jp/files/public/6/63366/20220413145719239838/figures20220413-1.pdfTest; https://ousar.lib.okayama-u.ac.jp/files/public/6/63366/20220413145719264474/tables20220413-1.pdfTest; https://ousar.lib.okayama-u.ac.jp/files/public/6/63366/20220413145719297864/FeaturedImage20220413-1.pdfTest; https://ousar.lib.okayama-u.ac.jp/files/public/6/63366/20220413145719350513/SI20220413-1.pdfTest; Infection; https://ousar.lib.okayama-u.ac.jp/63366Test |
| الإتاحة: | https://doi.org/10.1007/s15010-022-01799-7Test https://ousar.lib.okayama-u.ac.jp/files/public/6/63366/20220413145719177939/fulltext20220413-1.pdfTest https://ousar.lib.okayama-u.ac.jp/files/public/6/63366/20220413145719239838/figures20220413-1.pdfTest https://ousar.lib.okayama-u.ac.jp/files/public/6/63366/20220413145719264474/tables20220413-1.pdfTest https://ousar.lib.okayama-u.ac.jp/files/public/6/63366/20220413145719297864/FeaturedImage20220413-1.pdfTest https://ousar.lib.okayama-u.ac.jp/files/public/6/63366/20220413145719350513/SI20220413-1.pdfTest https://ousar.lib.okayama-u.ac.jp/63366Test |
| حقوق: | © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022 |
| رقم الانضمام: | edsbas.3936E85E |
| قاعدة البيانات: | BASE |
| تدمد: | 03008126 |
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