دورية أكاديمية
Orexin A and B in the rat superior salivatory nucleus
العنوان: | Orexin A and B in the rat superior salivatory nucleus |
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المؤلفون: | Sato, Tadasu, Yajima, Takehiro, Fujita, Masako, Kobashi, Motoi, Ichikawa, Hiroyuki, Yoshida, Ryusuke, Mitoh, Yoshihiro |
المصدر: | Autonomic Neuroscience |
بيانات النشر: | Elsevier |
سنة النشر: | 2020 |
المجموعة: | Okayama University Scientific Achievement Repository / 岡山大学学術成果リポジトリ |
مصطلحات موضوعية: | Orexin, Orexin receptor, Superior salivatory nucleus, Preganglionic neuron, Chorda-lingual nerve, Immunohistochemistry |
الوصف: | Orexin (OX), which regulates sleep and wakefulness and feeding behaviors has 2 isoforms, orexin-A and -B (OXA and OXB). In this study, the distribution of OXA and OXB was examined in the rat superior salivatory nucleus (SSN) using retrograde tracing and immunohistochemical and methods. OXA- and OXB-immunoreactive (-ir) nerve fibers were seen throughout the SSN. These nerve fibers surrounded SSN neurons retrogradely labeled with Fast blue (FB) from the corda-lingual nerve. FB-positive neurons had pericellular OXA- (47.5%) and OXB-ir (49.0%) nerve fibers. Immunohistochemistry for OX receptors also demonstrated the presence of OX1R and OX2R in FB-positive SSN neurons. The majority of FB-positive SSN neurons contained OX1R- (69.7%) or OX2R-immunoreactivity (57.8%). These neurons had small and medium-sized cell bodies. In addition, half of FB-positive SSN neurons which were immunoreactive for OX1R (47.0%) and OX2R (52.2%) had pericellular OXA- and OXB-ir nerve fibers, respectively. Co-expression of OX1R- and OX2R was common in FB-positive SSN neurons. The present study suggests a possibility that OXs regulate the activity of SSN neurons through OX receptors. |
نوع الوثيقة: | article in journal/newspaper |
اللغة: | English |
تدمد: | 1566-0702 |
العلاقة: | info:pmid/32721850; https://ousar.lib.okayama-u.ac.jp/files/public/6/60856/2020111209235131099/fulltext.pdfTest; https://ousar.lib.okayama-u.ac.jp/files/public/6/60856/20201112131450296789/fig1-10.pdfTest; AA11470577; https://ousar.lib.okayama-u.ac.jp/60856Test |
الإتاحة: | https://doi.org/10.1016/j.autneu.2020.102712Test https://ousar.lib.okayama-u.ac.jp/files/public/6/60856/2020111209235131099/fulltext.pdfTest https://ousar.lib.okayama-u.ac.jp/files/public/6/60856/20201112131450296789/fig1-10.pdfTest https://ousar.lib.okayama-u.ac.jp/60856Test |
رقم الانضمام: | edsbas.CFBFB92 |
قاعدة البيانات: | BASE |
تدمد: | 15660702 |
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