Therapeutic effects of quetiapine and 5-HT1A receptor agonism on hyperactivity in dopamine-deficient mice ; ドーパミン欠乏マウスの多動に対するクエチアピンおよび5-HT1A受容体作動の治療効果について
| العنوان: | Therapeutic effects of quetiapine and 5-HT1A receptor agonism on hyperactivity in dopamine-deficient mice ; ドーパミン欠乏マウスの多動に対するクエチアピンおよび5-HT1A受容体作動の治療効果について |
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| المؤلفون: | Ochiai, Yukiko, 落合, 郁紀子 |
| سنة النشر: | 2022 |
| المجموعة: | Niigata University Academic Repository (NUAR) / 新潟大学学術リポジトリ |
| مصطلحات موضوعية: | psychiatric symptoms, dopamine deficiency, dopamine-deficient mice, 5-HT1A receptor, Parkinson's disease |
| الوصف: | 新潟大学 ; Niigata University ; 博士（医学） ; Some diseases that are associated with dopamine deficiency are accompanied by psychiatric symptoms, such as Parkinson's disease. However, the mechanism by which this occurs has not been clarified. Previous studies found that dopamine-deficient (DD) mice exhibited hyperactivity in a novel environment. This hyperactivity is improved by clozapine and donepezil, which are used to treat psychiatric symptoms associated with dopamine deficiency (PSDD). We considered that DD mice could be used to study PSDD. In the present study, we sought to identify the pharmacological mechanism of PSDD. We conducted locomotor activity tests by administering quetiapine and drugs that have specific actions on serotonin (5-hydroxytryptamine [5-HT]) receptors and muscarinic receptors. Changes in neuronal activity that were induced by drug administration in DD mice were evaluated by examining Fos immunoreactivity. Quetiapine suppressed hyperactivity in DD mice. The 5-HT1A receptor antagonist WAY100635 inhibited this effect. The number of Fos-positive neurons in the median raphe nucleus increased in DD mice that exhibited hyperactivity and was decreased by treatment with quetiapine and 5-HT1A receptor agonists. In conclusion, hyperactivity in DD mice was ameliorated by quetiapine, likely through 5-HT1A receptor activation. These findings suggest that 5-HT1A receptors may play a role in PSDD, and 5-HT1A receptor-targeting drugs may help improve PSDD. ; International Journal of Molecular Sciences. 2022, 23(13), 7436. ; 新大院博(医)第1085号 ; doctoral thesis |
| نوع الوثيقة: | other/unknown material |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://doi.org/10.3390/ijms23137436Test; 甲第5072号; https://niigata-u.repo.nii.ac.jp/record/2000964/files/r4nmk1085.pdfTest; https://niigata-u.repo.nii.ac.jp/record/2000964/files/r4nmk1085_a.pdfTest |
| الإتاحة: | https://doi.org/10.3390/ijms23137436Test https://niigata-u.repo.nii.ac.jp/record/2000964/files/r4nmk1085.pdfTest https://niigata-u.repo.nii.ac.jp/record/2000964/files/r4nmk1085_a.pdfTest |
| حقوق: | © 2022 by the authors. ; Creative Commons Attribution 4.0 International ; open access |
| رقم الانضمام: | edsbas.6838AB12 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |