التفاصيل البيبلوغرافية
| العنوان: |
Cytosponge-trefoil factor 3 versus usual care to identify Barrett's oesophagus in a primary care setting: a multicentre, pragmatic, randomised controlled trial |
| المؤلفون: |
Fitzgerald RC, di Pietro M, O'Donovan M, Maroni R, Muldrew B, Debiram-Beecham I, Gehrung M, Offman J, Tripathi M, Smith SG, Aigret B, Walter FM, Rubin G, Bagewadi A, Patrick A, Shenoy A, Redmond A, Muddu A, Northrop A, Groves A, Shiner A, Heer A, Takhar A, Bowles A, Jarman A, Wong A, Lucas A, Gibbons A, Dhar A, Curry A, Lalonde A, Swinburn A, Turner A, Lydon A-M, Gunstone A, Lee A, Nambi A, Ariyarathenam A, Elden A, Wilson A, Donepudi B, Campbell B, Uszycka B, Bowers B, Coghill B, de Quadros B, Cheah C, Bratten C, Brown C, Moorbey C, Clisby C, Gordon C, Schramm C, Castle C, Newark C, Norris C, A'Court C, Graham C, Fletcher C, Grocott C, Rees C, Bakker C, Paschalides C, Vickery C, Schembri D, Morris D, Hagan D, Cronk D, Goddard D, Graham D, Phillips D, Prabhu D, Kejariwal D, Garg D, Lonsdale D, Butterworth D, Clements D, Bradman D, Blake D, Mather E, O'Farrell E, Markowetz F, Adams F, Pesola F, Forbes G, Taylor G, Collins G, Irvine G, Fourie G, Doyle H, Barnes H, Bowyer H, Whiting H, Beales I, Binnian I, Bremner I, Jennings I, Troiceanu I, Modelell I, Emmerson I, Ortiz J, Lilley J, Harvey J, Vicars J, Takhar J, Larcombe J, Bornschein J, Aldegather J, Johnson J, Ducker J, Skinner J, Dash J, Walsh J, Miralles J, Ridgway J, Ince J, Kennedy J, Hampson K, Milne K, Ellerby K, Priddis K, Rainsbury K, Powell K, Gunner K, Ragunath K, Knox K, Baseley L, White L, Lovat L, Berney L, Crockett L, Murray L, Westwood L, Chalkley L, Leggett L, Dale L, Scovell L, Brooks L, Saunders L, Owen L, Dilwershah M, Baldry M, Corcoran M, Roy M, Macedo M, Attah M, Anson M-J, Rutter M, Wallard M, Gaw M, Hunt M, Lea-Hagerty M, Penacerrada M, Bianchi M, Baker-Moffatt M, Czajkowski M, Sleeth M, Brewer N, Wooding N, Todd N, Millen N, Zolle O, Whitehead O, Ojechi P, Moore P, Banim P, Spellar P, Bhandari P, Kant P, Nixon R, Russell R, Roberts R, Skule R, West R, Fox R, Beesley R, Gibbins R, Osborne R, Thiagarajan S, Bastiman S, Warburton S, Pai S, Leith-Russell S, Utting S, Watson S, Wytrykowski S, Singh S, Malhotra S, Woods S, Conway S, Mateer S, Macrae S, Fourie S, Campbell S, Parslow-Williams S, Goel S, Dellar S, Jones S, Knight S, Mackay-Thomas S, Mukherjee S, Allen S, Henry S, Evans T, Leighton T, Bray T, Shackleton T, Santosh V, Glover V, Chandraraj V, Elson W, Briggs W, Barron Z, Khan Z, Sasieni P |
| المصدر: |
The Lancet, 1 - 7 August 2020 |
| بيانات النشر: |
Lancet Publishing Group |
| سنة النشر: |
2020 |
| المجموعة: |
Newcastle University Library ePrints Service |
| الوصف: |
© 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Treatment of dysplastic Barrett's oesophagus prevents progression to adenocarcinoma; however, the optimal diagnostic strategy for Barrett's oesophagus is unclear. The Cytosponge-trefoil factor 3 (TFF3) is a non-endoscopic test for Barrett's oesophagus. The aim of this study was to investigate whether offering this test to patients on medication for gastro-oesophageal reflux would increase the detection of Barrett's oesophagus compared with standard management. Methods: This multicentre, pragmatic, randomised controlled trial was done in 109 socio-demographically diverse general practice clinics in England. Randomisation was done both at the general practice clinic level (cluster randomisation) and at the individual patient level, and the results for each type of randomisation were analysed separately before being combined. Patients were eligible if they were aged 50 years or older, had been taking acid-suppressants for symptoms of gastro-oesophageal reflux for more than 6 months, and had not undergone an endoscopy procedure within the past 5 years. General practice clinics were selected by the local clinical research network and invited to participate in the trial. For cluster randomisation, clinics were randomly assigned (1:1) by the trial statistician using a computer-generated randomisation sequence; for individual patient-level randomisation, patients were randomly assigned (1:1) by the general practice clinics using a centrally prepared computer-generated randomisation sequence. After randomisation, participants received either standard management of gastro-oesophageal reflux (usual care group), in which participants only received an endoscopy if required by their general practitioner, or usual care plus an offer of the Cytosponge-TFF3 procedure, with a subsequent endoscopy if the procedure identified TFF3-positive cells (intervention group). The primary outcome was the diagnosis of ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| الإتاحة: |
https://eprint.ncl.ac.uk/fulltext.aspx?url=268639/B14780C4-8A2C-47BC-9862-F8229514B7A1.pdf&pub_id=268639Test |
| رقم الانضمام: |
edsbas.2075D167 |
| قاعدة البيانات: |
BASE |
