دورية أكاديمية
Oral administration of Bali Robusta coffee (Coffea canephora) extract prevented the reduction of Leydig cells and testosterone levels in male Wistar rats (Rattus norvegicus) with excessive physical training
| العنوان: | Oral administration of Bali Robusta coffee (Coffea canephora) extract prevented the reduction of Leydig cells and testosterone levels in male Wistar rats (Rattus norvegicus) with excessive physical training |
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| المؤلفون: | Ismalia, Kandy Rosa, Pangkahila, Wimpie, Sriwidyani, Ni Putu |
| المصدر: | Neurologico Spinale Medico Chirurgico; Vol 4 No 1 (2021); 37-41 ; 2621-2064 |
| بيانات النشر: | Indoscholar |
| سنة النشر: | 2021 |
| المجموعة: | Neurologico Spinale Medico Chirurgico Journal |
| مصطلحات موضوعية: | Bali Robusta coffee extract, Leydig cells, Testosterone, Overtraining |
| الوصف: | Background: Excessive exercise cause a deterioration of organ function and structure. Overtraining will cause reduce antioxidant reserve and excess free radical production. In this condition, there will be a decrease in the number of Leydig cells in the testis and followed by a decrease in testosterone level. Bali robusta coffee extract contains active compounds such as alkaloids, saponins, flavonoids, tannins and polyphenols. This study aims to prove whether Bali robusta coffee extract (Coffea canephora) can prevent a decrease in the number of Leydig cells and testosterone levels in male Wistar rats (Rattus norvegicus) with excessive physical training. Methods: Thirty-six rats were randomly divided into 2 groups: the control group (placebo aquabidest 2 ml) and the treatment group (Bali robusta coffee extract of 1 gram/kg BW). Both groups received excessive physical training in the form of swimming until the subjects experienced fatigue for 21-days. Results: The results showed that the mean of Leydig cell number in the treatment group was significantly higher, which was 3.70 ± 0.89 cell/field of view, compared to the control group, which was 2.92 ± 0.65 cell/field of view (p = 0.005). The mean testosterone level in the treatment group was also significantly higher, which was 6.32 ± 0.21 nmol/ml, compared to the control group, which was 1.95 ± 0.32 nmol/ml (p < 0.001). Conclusion: The administration of Bali robusta coffee extract (Coffea canephora) prevented a decrease in the number of Leydig cells and testosterone levels in male Wistar rats (Rattus norvegicus) with excessive physical training. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://indoscholar.com/nsmc/index.php/nsmc/article/view/151/140Test; https://indoscholar.com/nsmc/index.php/nsmc/article/view/151Test |
| DOI: | 10.36444/nsmc.v4i1.151 |
| الإتاحة: | https://doi.org/10.36444/nsmc.v4i1.151Test https://indoscholar.com/nsmc/index.php/nsmc/article/view/151Test |
| حقوق: | Copyright (c) 2021 Neurologico Spinale Medico Chirurgico ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.61799CF0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.36444/nsmc.v4i1.151 |
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