التفاصيل البيبلوغرافية
| العنوان: |
Methotrexate與Bromocriptine應用於中止母犬懷孕的探討 ; Application of Methotrexate and Bromocriptine in Termination of Pregnancy in Bitches |
| المؤلفون: |
翁源成, Weng, Yuan-Cheng |
| المساهمون: |
毛嘉洪, Frank Chiahung Mao |
| بيانات النشر: |
獸醫學系 |
| سنة النشر: |
1997 |
| المجموعة: |
National Chung Hsing University Institutional Repository - NCHUIR / 國立中興大學 |
| مصطلحات موضوعية: |
墮胎, methotrexate, 犬, 懷孕, bromocriptine, abortion, canine, pregnancy |
| الوصف: |
本研究使用methotrexate (MTX)和bromocriptine (BrC)二種藥物，來探 討對母犬懷孕中止的作用。其中MTX可以抑制DNA的合成，進而阻止細胞的 再生，而BrC可抑制泌乳素(prolactin)的分泌，而降低助孕素( progesterone)的濃度，使黃體無法維持。實驗中分析5隻正常懷孕母犬的 血液學、血清生化學數值及血清中助孕素的濃度，另使用MTX(5 mg/M2) 在5隻未配種母犬及8隻配種後5天、15天、25天，38天的懷孕母犬，分析 血液學和血清生化學數值，結果發現MTX使用在未懷孕母犬，以及懷孕母 犬會造成嚴重的副作用，特別是在懷孕後期更加明顯，且無法立即中止母 犬的懷孕。4隻以超音波確定懷孕的母犬，給予BrC (0.1 mg/Kg)後，發現 其助孕素濃度在投藥後第一天即開始下降，3隻懷孕40-50天的母犬流產發 生在投藥開始後第二或第三天，而一隻懷孕30天的母犬在投藥6天後以超 音波偵測，已無法偵測到胎兒影像，顯示BrC可成功的中止母犬中、後期 的懷孕。 ; Methotrexate (MTX) and bromocriptine (BrC) were used in this study for terminating pregnancy in bitches. MTX can block DNA synthesis. BrC can inhibit prolactin secreetion and decrease serum pregesterone conxentration. Blood count, serum biochemistry, and serum pregesterone concentrations were analyzed in five normal pregnant bitches, five MTX (5 mg/M2) treated bitches,and eight MTX (5 mg/M2) treated bitches in 5, 15, 25, 38 days of pregnancy.Strong side effects were found in MTX treated bitches, especially in bitches with 25 or 38 day of pregnancy. None of the eight pregnant bitches terminated their pregnancy after MTX treatment. Four ultrasound confirmed pregnant bitcheswere treated with BrC (0.1 mg/Kg). Serum progesterone concentrations weredecreased immediately after the first day of BrC treatment. Three bitches (40to 50 day of pregnancy) were aborted within 2 or 3 days after BrC Treatment. The fetus ultrasound image of a 30-day-pregnant bitch was undertectable aftera 6 day BrC treatment. BrC is proved useful in terminating mid or late pregnancy in bitches. |
| نوع الوثيقة: |
thesis |
| اللغة: |
English |
| العلاقة: |
http://hdl.handle.net/11455/13135Test |
| الإتاحة: |
http://hdl.handle.net/11455/13135Test |
| حقوق: |
none |
| رقم الانضمام: |
edsbas.BD30AC80 |
| قاعدة البيانات: |
BASE |
