رسالة جامعية
Μελέτη παραμέτρων αποπτωτικής διεργασίας στους όζους του θυρεοειδούς αδένα in vivo ; Study of apoptotic parameters in thyroid gland nodules in vivo
| العنوان: | Μελέτη παραμέτρων αποπτωτικής διεργασίας στους όζους του θυρεοειδούς αδένα in vivo ; Study of apoptotic parameters in thyroid gland nodules in vivo |
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| المؤلفون: | Karanikas, Michael, Καρανίκας, Μιχαήλ |
| بيانات النشر: | Democritus University of Thrace (DUTH) Δημοκρίτειο Πανεπιστήμιο Θράκης (ΔΠΘ) |
| سنة النشر: | 2006 |
| المجموعة: | National Archive of PhD Theses (National Documentation Centre Greece) |
| مصطلحات موضوعية: | Απόπτωση, Θυρεοειδής αδένας, Όζοι θυρεοειδούς, Κασπάσες, Θυρεοειδίτις, Θυλακιώδη αδενώματα, Apoptosis, Thyroid gland, Thyroid nodules, Caspase, FAS, Bcl-2, Thyroiditis, Follicular adenomas, Ιατρική και Επιστήμες Υγείας, Κλινική Ιατρική, Medical and Health Sciences, Clinical Medicine |
| الوصف: | The process of apoptosis in human cells is a normal and complex procedure for the organism in order to maintain the balance between normal cells destruction and rebirth. Potential disorders in the apoptotic paths that can result in the pathogenesis of various diseases, is currently a wide field of research worldwide. AIM: In this prospective clinical immunochistochemical study, an attempt is made to investigate the role of the apoptotic procedures in various thyroid diseases (solitary nodule, non-toxic multinodular goiter). MATERIAL: Fifty-five patients (9 male-46 female, mean age 55 years) were included in this study. The diseases were a) non-toxic multinodular goiter 30/55 (54,54%), b) toxic multinodular goiter 11/55 (20%) c) solitary “cold” nodule 11/55 (20%) and d) toxic adenoma 3/55 (5,46%). Total thyroidectomy was performed in all cases and the postoperative course was uncomplicated. METHODS: The expression of Fas and Bcl-2 proteins and p53 gene and ki67 antigen was studied in cytologic samples extracted by FNA under direct vision of the nodule and in the excised thyroid gland. For the trace and marking of the various targets, the abiding-biotin-hyperoxidase with diamino-benzidine (DAB) method was used. The values of TSH were also studied. The results were analyzed and compared using the fisher’s exact test or the unpaired two tailed t-test. RESULTS: The histology report showed 6 carcinomas (10,91%), 5 colloid nodules (9,1%), 30 follicular adenomas (54,55%), 3 hyperplastic nodules (5,45%), 2 focal thyroiditis (3,63%), 7 Hashimoto’s thyroiditis (12,73%) and 2 Grave’s disease (3,63%). Fas was found to be elevated (mean value 22,29) in Hashimoto’s thyroiditis, while the m.v. in follicular adenomas was 9,7 (p=0,05). In addition, the Fas expression was found to be elevated in normofollicular adenomas, compared to macrofollicular adenomas (p=0,04). The Bcl-2 expression was found to be elevated in Hashimoto’s thyroiditis (m.v. 77,4), while the m.v. in follicular adenomas was 52,14 (p=0,02). The ki67 antigen ... |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| اللغة: | Greek, Modern (1453-) |
| العلاقة: | http://hdl.handle.net/10442/hedi/17598Test |
| DOI: | 10.12681/eadd/17598 |
| الإتاحة: | https://doi.org/10.12681/eadd/17598Test http://hdl.handle.net/10442/hedi/17598Test |
| رقم الانضمام: | edsbas.1B35ADF |
| قاعدة البيانات: | BASE |
| DOI: | 10.12681/eadd/17598 |
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