رسالة جامعية
Kontinuirani glukozni monitoring u proceni glikemijske varijabilnosti kod pacijenata sa dijabetesom tipa 1
| العنوان: | Kontinuirani glukozni monitoring u proceni glikemijske varijabilnosti kod pacijenata sa dijabetesom tipa 1 |
|---|---|
| المؤلفون: | Ćirić, Vojislav |
| المساهمون: | Pešić, Milica |
| المصدر: | Универзитет у Нишу |
| بيانات النشر: | Универзитет у Нишу, Медицински факултет |
| سنة النشر: | 2023 |
| المجموعة: | NaRDuS (National Repository of Dissertations in Serbia) / Nacionalni Repozitorijum Disertacija u Srbiji |
| مصطلحات موضوعية: | Dijabetes mellitus tip 1, intenzivirana insulinska terapija, kontinuirana supkutana insulinska infuzija, glikemijska varijabilnost, hipoglikemija, kontinuirani glikemijski monitoring, Diabetes mellitus type 1, multiple daily injections insulin therapy, continuous subcutaneous insulin infusion, glycemic variability, hypoglycemia, continuous glucose monitoring |
| الوصف: | Glycemic variability (GV) represents the fluctuations of glycemia between high and low values. Reduction of HbA1c below 7% is an accepted goal for most patients with type 1 diabetes (T1DM), however strict glycemic control increases the risk of hypoglycemia. Achieving successful glycemic control is only possible through reduction of GV. Methods of assessing and presenting GV are still a matter of debate. Self-monitoring of glycemia (SMBG) can only roughly estimate GV. Continuous glucose monitoring (CGM) is a modern method that, by frequent (1-5 min) and precise measurement of the level of glucose in the intestinal fluid over a longer period of time (3-7 days), provides the possibility of assessing GV. The aims of this study are to compare GV in patients with T1DM receiving multiple daily injections of insulin (MDI) and patients receiving continuous insulin infusion therapy (CSII), and then to examine the association of HbA1c results with GV parameters, the association of registered hypoglycemic episodes with HbA1c and GV, as well as the association of GV with quality of life and treatment satisfaction. The study included 60 patients with T1DM divided into two groups - patients treated by MDI and patients treated by CSII. The patients performed masked (professional) CGM for 6 days, with mandatory SMBG and recorded daily activities, meals and physical activity. The parameters determined by the CGM method are average glycemia, SD, estimated HbA1c, time in range (TIR), time above range (TAR), time below range (TBR), AUC (area under curve) for hyperglycemia and hypoglycemia. The following were aditionally calculated: CV, MAGE (mean amplitude of glycemic excursions), MAG change (mean absolute glucose change), MODD (mean daily difference of blood glucose), CONGA (continuous overall net glucose action), J-index, LI (lability index), M-value, GRADE (the glycemic risk assessment diabetes equation), GRADE Hyper, GRADE Hypo, ADDR (average daily risk range), HBGI (high blood glucose index), LBGI (low blood glucose index). ... |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| وصف الملف: | application/pdf |
| اللغة: | Serbian |
| العلاقة: | http://eteze.ni.ac.rs/application/showtheses?thesesId=8626Test; https://fedorani.ni.ac.rs/fedora/get/o:1918/bdef:Content/downloadTest; https://plus.cobiss.net/cobiss/sr/sr/bib/123162889Test; https://nardus.mpn.gov.rs/handle/123456789/21796Test; http://nardus.mpn.gov.rs/bitstream/id/155741/Doctoral_thesis_14152.pdfTest; http://nardus.mpn.gov.rs/bitstream/id/155742/Ciric_Vojislav.pdfTest; https://hdl.handle.net/21.15107/rcub_nardus_21796Test |
| الإتاحة: | https://nardus.mpn.gov.rs/handle/123456789/21796Test http://eteze.ni.ac.rs/application/showtheses?thesesId=8626Test https://fedorani.ni.ac.rs/fedora/get/o:1918/bdef:Content/downloadTest https://plus.cobiss.net/cobiss/sr/sr/bib/123162889Test http://nardus.mpn.gov.rs/bitstream/id/155741/Doctoral_thesis_14152.pdfTest http://nardus.mpn.gov.rs/bitstream/id/155742/Ciric_Vojislav.pdfTest https://hdl.handle.net/21.15107/rcub_nardus_21796Test |
| حقوق: | openAccess ; https://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; BY-NC-ND |
| رقم الانضمام: | edsbas.ED755AD1 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |