| الوصف: |
Background: Globally, the burden of Diabetes Mellitus (DM) and Helicobacter pylori (H. pylori) infection is vast, both conferring significant morbidity and mortality risks. H. pylori, categorized as a class 1 carcinogen by WHO, has been identified as a common pathogen in DM, and has also been linked to altered glucose metabolism, increasing risk of gastric malignancy and DM complications. While it is thought that patients with DM are at increased risk of acquiring H. pylori, because of impairment in their humoral and cellular immunity, the results of several studies investigating this association are conflicting. Data on this association is limited in sub–Saharan Africa, including Kenya. Objectives: To determine the prevalence of H. pylori in patients with and without DM, and to describe any association between DM and H. pylori infection, in patients attending clinics at Moi Teaching and Referral Hospital (MTRH) Eldoret, Kenya. Methods: This hospital-based cross-sectional comparative study was conducted at outpatient clinics, MTRH, Eldoret, between December 2020 and April 2021. A total of 470 unmatched participants were enrolled. (232 with DM and 238 without DM). H pylori prevalence was compared between those with DM and those without DM using H. pylori antibody test. Null hypothesis was that the prevalence of H. pylori is similar in both groups. Two sampling techniques were employed: 1) systematic random sampling for the DM group and 2) simple random sampling for the non-DM group. Standardized interviewer administered questionnaires were used to collect demographic, socioeconomic and medical history data. H. pylori serum antibody tests were done and recorded for both groups. Categorical data were summarized using frequencies and continuous variables were summarized using means and medians with corresponding SD and IQR respectively. Bivariate analysis was conducted to test for association. Level of significance was set at p<0.05. This study was approved by the MTRH/Moi University Institutional Research and ... |
