دورية أكاديمية
Functional Gallic Acid-Based Dendrimers as Synthetic Nanotools to Remodel Amyloid-β-42 into Noncytotoxic Forms
| العنوان: | Functional Gallic Acid-Based Dendrimers as Synthetic Nanotools to Remodel Amyloid-β-42 into Noncytotoxic Forms |
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| المؤلفون: | Rodrigues Araújo, Ana Rita, Correa Chinea, Juan Francisco, Domínguez Arca, Vicente, Reis, Rui L., Fernández Megía, Eduardo, Rodrigues Pires, Ricardo Alexandre |
| المساهمون: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares, Universidade de Santiago de Compostela. Departamento de Física Aplicada, Universidade de Santiago de Compostela. Departamento de Química Orgánica |
| بيانات النشر: | ACS Publications |
| المجموعة: | Minerva - Repositorio institucional da Universidade de Santiago de Compostela (USC) |
| مصطلحات موضوعية: | Dendrimers, Gallic acid, Amyloid-β, Supramolecular assembly, Alzheimer’s disease |
| الوصف: | The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsami.1c17823Test. Synthesis and characterization of dendrimers, studies of interference of dendrimers in the Aβ supramolecular assembly, and cell studies ; The self-assembly of amyloid-β (Aβ) generates cytotoxic oligomers linked to the onset and progression of Alzheimer’s disease (AD). As many fundamental molecular pathways that control Aβ aggregation are yet to be unraveled, an important strategy to control Aβ cytotoxicity is the development of bioactive synthetic nanotools capable of interacting with the heterogeneous ensemble of Aβ species and remodel them into noncytotoxic forms. Herein, the synthesis of nanosized, functional gallic acid (Ga)-based dendrimers with a precise number of Ga at their surface is described. It is shown that these Ga-terminated dendrimers interact by H-bonding with monomeric/oligomeric Aβ species at their Glu, Ala, and Asp residues, promoting their remodeling into noncytotoxic aggregates in a process controlled by the Ga units. The multivalent presentation of Ga on the dendrimer surface enhances their ability to interact with Aβ, inhibiting the primary and secondary nucleation of Aβ fibrillization and disrupting the Aβ preformed fibrils ; The authors acknowledge the financial support from the EC (FORECAST-668983), “Programa Operacional Regional do Norte”, “Fundo Social Europeu”, Norte2020 TERM&SC, for the PhD grant NORTE-08-5369-FSE-000044, the SpanishMinistry of Science and Innovation (RTI2018-102212-B-I00), the Xunta de Galicia (ED431C 2018/30; Centro singular de investigación de Galicia accreditation 2019−2022, ED431G 2019/03), European Regional Development Fund-ERDF, and the Galician Supercomputing Centre (CESGA) and the MAT2016-80266-R of the Spanish Ministry of Science and Innovation ; SI |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1944-8244 1944-8252 |
| العلاقة: | https://doi.org/10.1021/acsami.1c17823Test; ACS Appl. Mater. Interfaces 2021, 13, 50, 59673–59682; http://hdl.handle.net/10347/28892Test |
| DOI: | 10.1021/acsami.1c17823 |
| الإتاحة: | https://doi.org/10.1021/acsami.1c17823Test http://hdl.handle.net/10347/28892Test |
| حقوق: | © 2021 American Chemical Society. This work is licenced under a Creative Commons Attribution 4.0 International licence (https://creativecommons.org/licenses/by/4.0/legalcodeTest) ; Atribución 4.0 Internacional ; http://creativecommons.org/licenses/by/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.DE4C0156 |
| قاعدة البيانات: | BASE |
| تدمد: | 19448244 19448252 |
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| DOI: | 10.1021/acsami.1c17823 |