دورية أكاديمية
The early-life exposome and epigenetic age acceleration in children
| العنوان: | The early-life exposome and epigenetic age acceleration in children |
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| المؤلفون: | Prado Bert, Paula de, Ruiz-Arenas, Carlos, Vives-Usano, Marta, Andrusaityte, Sandra, Cadiou, Solène, Carracedo Álvarez, Ángel María, Casas, Maribel, Chatzi, Leda, Dadvand, Payam, González Ruiz, Juan Ramon, Grazuleviciene, Regina, Gutzkow, Kristine Bjerve, Haug, Line Småstuen, Hernandez Ferrer, Carles, Keun, Hector C., Lepeule, Johanna, Maitre, Léa, McEachan, Rosemary, Nieuwenhuijsen, Mark J., Pelegrí, Dolors, Robinson, Oliver, Slama, Rémy, Vafeiadi, Marina, Sunyer, Jordi, Vrijheid, Martine, Bustamante, Mariona |
| المساهمون: | Universidade de Santiago de Compostela. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia, e Pediatría |
| بيانات النشر: | Elsevier |
| المجموعة: | Minerva - Repositorio institucional da Universidade de Santiago de Compostela (USC) |
| مصطلحات موضوعية: | Aging, Epigenetic age acceleration, Pregnancy, Childhood, Environmental exposures |
| الوصف: | The early-life exposome influences future health and accelerated biological aging has been proposed as one of the underlying biological mechanisms. We investigated the association between more than 100 exposures assessed during pregnancy and in childhood (including indoor and outdoor air pollutants, built environment, green environments, tobacco smoking, lifestyle exposures, and biomarkers of chemical pollutants), and epigenetic age acceleration in 1,173 children aged 7 years old from the Human Early-Life Exposome project. Age acceleration was calculated based on Horvath’s Skin and Blood clock using child blood DNA methylation measured by Infinium HumanMethylation450 BeadChips. We performed an exposure-wide association study between prenatal and childhood exposome and age acceleration. Maternal tobacco smoking during pregnancy was nominally associated with increased age acceleration. For childhood exposures, indoor particulate matter absorbance (PMabs) and parental smoking were nominally associated with an increase in age acceleration. Exposure to the organic pesticide dimethyl dithiophosphate and the persistent pollutant polychlorinated biphenyl-138 (inversely associated with child body mass index) were protective for age acceleration. None of the associations remained significant after multiple-testing correction. Pregnancy and childhood exposure to tobacco smoke and childhood exposure to indoor PMabs may accelerate epigenetic aging from an early age ; The study received funding from the European Community’s Seventh Framework Programme (FP7/2007-206) (grant agreement no 308333) (HELIX project), the H2020-EU.3.1.2. - Preventing Disease Programme (grant agreement no 874583) (ATHLETE project), and from the European Union’s Horizon 2020 research and innovation programme (grant Agreement number: 733206) (Early Life stressors and Lifecycle Health (LIFECYCLE)). BiB received funding from the Welcome Trust (WT101597MA), from the UK Medical Research Council (MRC) and Economic and Social Science Research Council (ESRC) ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0160-4120 |
| العلاقة: | https://doi.org/10.1016/j.envint.2021.106683Test; info:eu-repo/grantAgreement/EC/FP7/308333; info:eu-repo/grantAgreement/EC/H2020/874583; info:eu-repo/grantAgreement/EC/H2020/733206; info:eu-repo/grantAgreement/EC/FP7/211250; info:eu-repo/grantAgreement/EC/FP7/226285; Environment International 2021, 155: 106683. https://doi.org/10.1016/j.envint.2021.106683Test; http://hdl.handle.net/10347/26749Test |
| DOI: | 10.1016/j.envint.2021.106683 |
| الإتاحة: | https://doi.org/10.1016/j.envint.2021.106683Test http://hdl.handle.net/10347/26749Test |
| حقوق: | © 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0Test/) ; Atribución 4.0 Internacional ; http://creativecommons.org/licenses/by/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.17B3969D |
| قاعدة البيانات: | BASE |
| تدمد: | 01604120 |
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| DOI: | 10.1016/j.envint.2021.106683 |