دورية أكاديمية
Scientific Reports / Angiotensin II synergizes with BAFF to promote atheroprotective regulatory B cells
| العنوان: | Scientific Reports / Angiotensin II synergizes with BAFF to promote atheroprotective regulatory B cells |
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| المؤلفون: | Ait-Oufella, Hafid, Ponnuswamy, Padmapriya, Joffre, Jeremie, Herbin, Olivier, Esposito, Bruno, Laurans, Ludivine, Binder, Christoph J., Tedder, Thomas F., Zeboudj, Lynda, Loyer, Xavier, Giraud, Andreas, Zhang, Yujiao, Tedgui, Alain, Mallat, Ziad |
| بيانات النشر: | Nature |
| سنة النشر: | 2017 |
| المجموعة: | MedUni Vienna ePub (Medzinische Universität Wien) |
| مصطلحات موضوعية: | Cell polarity, Immunology |
| جغرافية الموضوع: | UMW:18376, UMW:14581 |
| الوصف: | Angiotensin II (AngII) promotes hypertension, atherogenesis, vascular aneurysm and impairs post-ischemic cardiac remodeling through concerted roles on vascular cells, monocytes and T lymphocytes. However, the role of AngII in B lymphocyte responses is largely unexplored. Here, we show that chronic B cell depletion (Baffr deficiency) significantly reduces atherosclerosis in Apoe −/− mice infused with AngII. While adoptive transfer of B cells in Apoe −/− /Baffr −/− mice reversed atheroprotection in the absence of AngII, infusion of AngII in B cell replenished Apoe −/− /Baffr −/− mice unexpectedly prevented the progression of atherosclerosis. Atheroprotection observed in these mice was associated with a significant increase in regulatory CD1dhiCD5+ B cells, which produced high levels of interleukin (IL)-10 (B10 cells). Replenishment of Apoe −/− /Baffr −/− mice with Il10 −/− B cells reversed AngII-induced B cell-dependent atheroprotection, thus highlighting a protective role of IL-10+ regulatory B cells in this setting. Transfer of AngII type 1A receptor deficient (Agtr1a −/−) B cells into Apoe −/− /Baffr −/− mice substantially reduced the production of IL-10 by B cells and prevented the AngII-dependent atheroprotective B cell phenotype. Consistent with the in vivo data, AngII synergized with BAFF to induce IL-10 production by B cells in vitro via AngII type 1A receptor. Our data demonstrate a previously unknown synergy between AngII and BAFF in inducing IL-10 production by B cells, resulting in atheroprotection. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text/html |
| اللغة: | English |
| تدمد: | 2045-2322 |
| العلاقة: | vignette : https://repositorium.meduniwien.ac.at/titlepage/urn/urn:nbn:at:at-ubmuw:3-55514/128Test; urn:nbn:at:at-ubmuw:3-55514; https://resolver.obvsg.at/urn:nbn:at:at-ubmuw:3-55514Test; local:99146557481703331; system:AC16448802 |
| DOI: | 10.1038/s41598-017-04438-6 |
| الإتاحة: | https://doi.org/10.1038/s41598-017-04438-6Test https://resolver.obvsg.at/urn:nbn:at:at-ubmuw:3-55514Test |
| حقوق: | cc-by_4 |
| رقم الانضمام: | edsbas.888A2105 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-017-04438-6 |