دورية أكاديمية
International Journal of Molecular Sciences / Recent advances in practical methods for liver cell biology: A short overview
| العنوان: | International Journal of Molecular Sciences / Recent advances in practical methods for liver cell biology: A short overview |
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| المؤلفون: | Trebicka, Jonel, Torres, Sandra, Abdullah, Zeinab, Brol, Maximilian, Hellerbrand, Claus, Fernandez, Mercedes, Fiorotto, Romina, Klein, Sabine, Königshofer, Philipp, Liedtke, Christian |
| بيانات النشر: | MDPI |
| سنة النشر: | 2020 |
| المجموعة: | MedUni Vienna ePub (Medzinische Universität Wien) |
| مصطلحات موضوعية: | hepatic stellate cells, hepatocellular cancer, fibrogenesis, steatosis, in vitro models |
| جغرافية الموضوع: | vls-obvumw-8305030, UMW:17643 |
| الوصف: | Molecular and cellular research modalities for the study of liver pathologies have been tremendously improved over the recent decades. Advanced technologies offer novel opportunities to establish cell isolation techniques with excellent purity, paving the path for 2D and 3D microscopy and high-throughput assays (e.g., bulk or single-cell RNA sequencing). The use of stem cell and organoid research will help to decipher the pathophysiology of liver diseases and the interaction between various parenchymal and non-parenchymal liver cells. Furthermore, sophisticated animal models of liver disease allow for the in vivo assessment of fibrogenesis, portal hypertension and hepatocellular carcinoma (HCC) and for the preclinical testing of therapeutic strategies. The purpose of this review is to portray in detail novel in vitro and in vivo methods for the study of liver cell biology that had been presented at the workshop of the 8th meeting of the European Club for Liver Cell Biology (ECLCB-8) in October of 2018 in Bonn, Germany. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text/html |
| اللغة: | English |
| تدمد: | 1422-0067 |
| العلاقة: | vignette : https://repositorium.meduniwien.ac.at/titlepage/urn/urn:nbn:at:at-ubmuw:3-85371/128Test; urn:nbn:at:at-ubmuw:3-85371; https://resolver.obvsg.at/urn:nbn:at:at-ubmuw:3-85371Test; local:99147796353103331; system:AC17023845 |
| DOI: | 10.3390/ijms21062027 |
| الإتاحة: | https://doi.org/10.3390/ijms21062027Test https://resolver.obvsg.at/urn:nbn:at:at-ubmuw:3-85371Test |
| حقوق: | cc-by_4 |
| رقم الانضمام: | edsbas.1E8C3A4F |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 |
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| DOI: | 10.3390/ijms21062027 |