دورية أكاديمية
Dynamics of cellular immunity indicators in the complex treatment of acute optic neuritis ; Динамика показателей клеточного иммунитета при комплексном лечении острого оптического неврита
| العنوان: | Dynamics of cellular immunity indicators in the complex treatment of acute optic neuritis ; Динамика показателей клеточного иммунитета при комплексном лечении острого оптического неврита |
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| المؤلفون: | D. A. Storozhilova, O. V. Kolenko, L. P. Danilova, L. P. Emanova, I. V. Vasilieva, Д. А. Сторожилова, О. В. Коленко, Л. П. Данилова, Л. П. Еманова, И. В. Васильева |
| المصدر: | Medical Immunology (Russia); Том 25, № 5 (2023); 1013-1018 ; Медицинская иммунология; Том 25, № 5 (2023); 1013-1018 ; 2313-741X ; 1563-0625 |
| بيانات النشر: | SPb RAACI |
| سنة النشر: | 2023 |
| المجموعة: | Medical Immunology (E-Journal) / Медицинская иммунология |
| مصطلحات موضوعية: | имунофан, herpes virus infection, corticosteroid therapy, immunomodulatory therapy, indicators of cellular immunity, imunofan, герпесвирусная инфекция, кортикостероидная терапия, иммуномодулирующая терапия, показатели клеточного иммунитета |
| الوصف: | An increase in the incidence of optic neuritis among the working-age population, as well as an unpromising prognosis for vision due to the development of optic nerve atrophy, determines the high social significance of this problem. The aim of the work is to analyze the effect of Imunofan at the parameters of cellular immunity and clinical symptoms of the disease in the complex treatment of optic neuritis associated with herpes virus infection. The study involved 37 people (37 eyes) with acute optic neuritis associated with herpes infection. The treatment regimen included the appointment of a dexamethasone solution according to a decreasing scheme, a 1% solution of the drug Emoxipin 0.5 mL and a 12.5% solution of the drug Dicynone 0.5 mL through an irrigation system implanted in the retrobulbar space, in combination with the neuroprotection drugs (Pikamilon and Semax) for 10 days. All patients were divided into 2 groups. The main group consisted of 20 patients who received Imunofan to the treatment regimen in addition. The comparison group included 17 patients who were treated only according to the method described above. The course of treatment lasted 10 days. The analysis of the data showed a more significant positive dynamics of cellular immunity parameters in those who received immunotherapy. Our studies showed the effectiveness of this drug in the complex treatment of optic neuritis associated with herpes infection, what is confirmed by the acceleration of inflammation relief, a more significant increase in visual functions of patients treated with Imunofan, and a lower percentage of optic nerve atrophy. In this group of patients, changes in the parameters of the cellular link of immunity occurred earlier and remained stable throughout the entire period of observation. According to our data, an intergroup assessment of the immunoregulatory index showed its faster increase in patients of the comparison group who received Imunofan, and reached normal values already 6 months after treatment. The clinical ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
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| DOI: | 10.15789/1563-0625-DOC-2741 |
| الإتاحة: | https://doi.org/10.15789/1563-0625-DOC-2741Test https://www.mimmun.ru/mimmun/article/view/2741Test |
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| رقم الانضمام: | edsbas.65DAF0A4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.15789/1563-0625-DOC-2741 |
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