التفاصيل البيبلوغرافية
| العنوان: |
Use of Microneedle Device to Enhance Dermal Absorption: Study on Ex VivoHuman Skin |
| المؤلفون: |
Hanan Osman Ponchet*, Marion Alriquet, Magali Kouidhi, Karine Sevin, Alexandre Gaborit and Claire E Wilson |
| بيانات النشر: |
MedCrave |
| سنة النشر: |
2018 |
| المجموعة: |
MedCrave |
| مصطلحات موضوعية: |
Spectrofluorometry, Rhodamine 123, Fluorescence, Saturated hygrometry, Cell incubator, Skin culture medium, Ex vivo, Stratum corneum, Microneedle, Cryomatrix, Haematoxylin, Transepidermal Water Loss, Hair regeneration, Cellulite treatment, Scar treatment |
| الوصف: |
The present study investigated the effects of microneedle roller device on dermal delivery of Rhodamine 123 on ex vivohuman skin. The effect of microneedle treatment on transepidermal water loss (TEWL) was also evaluated. Permeation studies of Rhodamine 123 through full-thickness human skin were conducted using modified Franz diffusion cells. The results showed that TEWL increased with the number of passes of the roller device. In addition, results of the in vitropermeation studies revealed marked increase of the absorption and the distribution of Rhodamine 123 through microneedle-treated skin. The increase of skin absorption was dependent on needle length. Thus, microneedle roller device markedly increased the absorption and distribution of Rhodamine 123 in ex vivohuman skin and could be suitable for clinical and preclinical use in order to enhance dermal delivery of test molecules. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
http://medcraveonline.com/JDC/JDC-02-00032.pdfTest |
| الإتاحة: |
http://medcraveonline.com/JDC/JDC-02-00032.pdfTest |
| حقوق: |
http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.42C1F235 |
| قاعدة البيانات: |
BASE |
