التفاصيل البيبلوغرافية
| العنوان: |
Comparison of Levonorgestrel-Releasing Intrauterine System, Medroxyprogesterone and Norethisterone for Treatment of Endometrial Hyperplasia without Atypia: A Randomized Clinical Trial |
| المؤلفون: |
Mohamed Rezk*, Mohamed Kandil, Said Saleh and Abdelhamid Shaheen |
| بيانات النشر: |
MedCrave |
| سنة النشر: |
2016 |
| المجموعة: |
MedCrave |
| مصطلحات موضوعية: |
Endometrial hyperplasia, Levonorgestrel-releasing intrauterine system, Medroxyprogesterone, Norethisterone, Perimenopausal bleeding |
| الوصف: |
Objective:to assess the efficacy, acceptability and cost-effectiveness of the levonorgestrel-releasing intrauterine system (LNG-IUS) compared to oral Medroxyprogesterone (MPA) and Norethisterone (NETA) for treatment of endometrial hyperplasia (EH) without atypia in perimenopausal women. Methods:This randomized clinical study included 150 perimenopausal women with endometrial hyperplasia (EH) without atypia who were randomly assigned into three groups; 50 patients received 15 mg Medroxyprogesterone acetate (MPA), 50 patients received 15 mg Norethisterone acetate (NETA) and 50 patients in whom levonorgestrel-releasing intrauterine system (LNG-IUS) was inserted. Endometrial sampling was repeated after 6 months of therapy. Primary outcome was regression of EH while secondary outcomes included side effects, patient acceptability and cost of treatment over six months. Results:There was no significant difference between the three groups regarding regression of EH (p<0.05). The LNG-IUS has the highest cost and acceptability (p<0.001). There was a significant higher women suffering from nausea in NETA group (p<0.05), acne in MPA group(P<0.05) and vaginal discharge in LNG-IUS group(p<0.05). Conclusion:In low-income and developing countries where the LNG-IUS is non affordable or unavailable, the use of norethisterone seems a viable cost-effective therapy in patients with endometrial hyperplasia without atypia. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
http://medcraveonline.com/OGIJ/OGIJ-05-00163.pdfTest |
| الإتاحة: |
http://medcraveonline.com/OGIJ/OGIJ-05-00163.pdfTest |
| حقوق: |
http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.24CE2374 |
| قاعدة البيانات: |
BASE |
