التفاصيل البيبلوغرافية
| العنوان: |
Expression of Er, Pr, Ki-67and Her-2 in Breast Cancer Diagnosis using Archival Tissue Block from Olabisi Onabanjo Teaching Hospital Shagamu and Institute of Advance Medical Research Training Ibadan |
| المؤلفون: |
Olawale Saheed Asimiyu, Peter UAchukwu, Nosa Terry Omorodion, Esohe A Ajayi, and Evbayiro N Omobogie |
| بيانات النشر: |
MedCrave |
| سنة النشر: |
2017 |
| المجموعة: |
MedCrave |
| مصطلحات موضوعية: |
Immunohistochemistry, Carcinoma, Metastasis, Estrogen receptors, IHC, Anti-ER, HER2, Prognostic, Markers, Prosterone receptors, Human epidermal, Ki-67, Primary tumor, Post treatment, Negative, Sarcoma, Lymphoma, Mesothelioma, Melanoma |
| الوصف: |
Immunohistochemistry is used to characterize various surface and intracellular proteins from cells of all tissues. Individual markers and more often panels of various marker proteins can be used to distinguish carcinoma from sarcoma or lymphoma, mesothelioma or melanoma, characterize various tumor subtypes, confirm tissue of origin, help distinguish metastatic from primary tumor and provide additional information about tumors, which may be important for staging, prognosis, predicting response to therapy or evaluating for residual tumor post treatment. The most common panel is one used for breast cancer patients to determine hormone receptor expression and other markers that predict response to certain therapies and determine risk of recurrence to assist in treatment decisions such as surgery, radiation therapy and chemotherapy. Common breast cancer prognostic and therapeutic markers used include: ER , HER2, Ki-67 and PR . Aim of the study is to demonstrate immunohistochemistry markers on samples. Objective: To confirm the superiority of IHC over conventional H$E. The trend shows that 58.5% of the patients were HER-2 and Ki-67 negative. This is an indication that there is likelihood for the patient to survive through effective treatment. The analysis indicated that 1(2.4%) patients were (ER, PR) positive and Ki-67 negative. It also shows that 10(24.3%) patients were (ER, PR) negative and Ki-67 positive. Findings also show that 2(4.9%) patients were (ER, PR) positive and Ki-67 positive. Finally, it shows that 19(46.3%) patients were (ER, PR) negative and Ki-67 negative. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
http://medcraveonline.com/MOJBM/MOJBM-01-00017.pdfTest |
| الإتاحة: |
http://medcraveonline.com/MOJBM/MOJBM-01-00017.pdfTest |
| حقوق: |
http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.6CF5FF0 |
| قاعدة البيانات: |
BASE |
