التفاصيل البيبلوغرافية
| العنوان: |
Specific Increase in Joint Neutrophil Extracellular Traps and Its Relation to Interleukin 6 in Autoimmune Arthritis |
| المؤلفون: |
Ayako Ohyama, Atsumu Osada, Hoshimi Kawaguchi, Izumi Kurata, Taihei Nishiyama, Tamaki Iwai, Akihito Ishigami, Yuya Kondo, Hiroto Tsuboi, Takayuki Sumida, Isao Matsumoto |
| المصدر: |
International Journal of Molecular Sciences; Volume 22; Issue 14; Pages: 7633 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2021 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
neutrophil extracellular traps, interleukin-6, citrullinated proteins, rheumatoid arthritis |
| جغرافية الموضوع: |
agris |
| الوصف: |
Neutrophils and their extracellular traps have been shown to play an important role in the pathogenesis of rheumatoid arthritis (RA), but the detailed mechanisms in joints are still unclear, and their regulation remains to be solved. Here, we explored neutrophil extracellular trap (NET)osis in experimental models of arthritis and further investigated the effects of interleukin-6 (IL-6) inhibition in neutrophils and NETosis. In skins of peptide GPI-induced arthritis (pGIA), citrullinated protein was detected as well as citrullinated histone expression in immunized skin but this was not specific to pGIA. Citrullinated histone expression in pGIA joints was specific to pGIA and was merged with neutrophil elastase, suggesting NETosis. Neutrophils in joints tend to upregulate IL-6 receptors when compared with bone marrow neutrophils. Administration of mouse anti-IL-6 receptor antibodies in pGIA suppressed arthritis in association with a decrease in neutrophil infiltration and NETosis in joints. In the plasma of RA patients, citrullinated protein was significantly reduced after tocilizumab treatment. Our results suggest that IL-6 enhances neutrophil chemotaxis and NETosis in inflammatory joints and could be the source of citrullinated proteins. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Molecular Immunology; https://dx.doi.org/10.3390/ijms22147633Test |
| DOI: |
10.3390/ijms22147633 |
| الإتاحة: |
https://doi.org/10.3390/ijms22147633Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.93576568 |
| قاعدة البيانات: |
BASE |
