المؤلفون: Angela Spinelli, Laura Censi, Donatella Mandolini, Silvia Ciardullo, Michele Antonio Salvatore, Gianfranco Mazzarella, Paola Nardone

المصدر: Nutrients ; Volume 15 ; Issue 18 ; Pages: 3893

مصطلحات موضوعية: fruit and vegetables, sugar-sweetened beverages, physical activity, screen time, overweight, obesity, parental education, residence, citizenship, socio-economic characteristics

جغرافية الموضوع: agris

الوصف: Unhealthy diets, physical inactivity and high body mass index (BMI) are preventable risk factors for non-communicable diseases throughout a person’s lifespan. The higher prevalence of these risk factors in children from lower socio-economic groups has been generally observed. The aim of this study is to explore the effect of parents’ socio-economic conditions on children’s consumption of fruit, vegetables and sugar-sweetened drinks, and inactivity, sedentary behaviour, overweight and obesity. This study used data from the sixth cross-sectional survey of the surveillance “OKkio alla Salute” (Italian COSI), involving 2467 schools and 53,275 children in 2019. All the information was collected through four questionnaires addressed to parents, children, teachers and head teachers. The weights and heights of the children were measured with standard techniques and equipment to classify overweight/obesity according to the WOF-IOTF cut-offs. The results showed a high percentage of children who do not adhere to health recommendations and a high prevalence of overweight and obesity. In particular, “less healthy” behaviours and higher BMI were more frequent in children from families with a lower socio-economic status and those residing in Southern Italy. These findings highlight the need for effective interventions that address the differences in these health-related behaviours.

وصف الملف: application/pdf

العلاقة: Nutrition Methodology & Assessment; https://dx.doi.org/10.3390/nu15183893Test

الإتاحة: https://doi.org/10.3390/nu15183893Test

المؤلفون: Francesca Pennino, Maddalena Di Lillo, Michele Sorrentino, Claudio Fiorilla, Antonio Parisi, Pasquale Domenico Mirizzi, Bruna De Simone, Paolo Montuori, Maria Triassi, Antonio Nardone

المصدر: Healthcare; Volume 11; Issue 16; Pages: 2253

مصطلحات موضوعية: hearing health, KAP model, knowledge, attitude, behaviors

الوصف: Hearing health prevention has emerged as a significant public health concern worldwide. With nearly two and a half billion people experiencing some degree of hearing loss, and around seven hundred million requiring medical intervention, the impact on global health is substantial. The economic burden is equally substantial, with estimated health costs reaching 980 billion dollars in the United States alone. To shed light on this issue, we conducted a survey-based cross-sectional study involving 1150 individuals. Utilizing multiple linear regression across three models, we aimed to explore the association between demographic variables and knowledge, attitude, and behaviors related to hearing health. In Model I, we observed a correlation between knowledge and several factors, including age, smoking habits, marital status, and education. In Model II, attitudes were found to associate with non-smoking habits, education, and knowledge. Model III revealed a statistically significant correlation between behaviors and age, gender, parenthood, knowledge, and attitudes. These findings emphasize the importance of targeted public health programs aimed at improving behaviors among the general population. Such interventions can be both effective and relatively inexpensive. By addressing these determinants, we can enhance overall hearing health in the community. Our study contributes valuable information about the knowledge, attitudes, and behaviors related to hearing health in the general population. Understanding these factors is crucial in developing evidence-based strategies to promote hearing health and prevent hearing loss effectively. As we continue to work towards better hearing health, the findings from this study can serve as a cornerstone for informed decision-making and successful intervention implementation.

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العلاقة: https://dx.doi.org/10.3390/healthcare11162253Test

الإتاحة: https://doi.org/10.3390/healthcare11162253Test

المؤلفون: Alfonso Reginelli, Vittorio Patanè, Fabrizio Urraro, Anna Russo, Marco De Chiara, Alfredo Clemente, Umberto Atripaldi, Giovanni Balestrucci, Mauro Buono, Emma D’ippolito, Roberta Grassi, Ida D’onofrio, Stefania Napolitano, Teresa Troiani, Ferdinando De Vita, Fortunato Ciardiello, Valerio Nardone, Salvatore Cappabianca

المصدر: Diagnostics; Volume 13; Issue 14; Pages: 2334

مصطلحات موضوعية: magnetic resonance, oncologic, radiotherapy, oncologic diagnostics, bone metastases, lung cancer, breast cancer, prostate cancer, whole-body diffusion weighted imaging, whole body-MRI

الوصف: Metastasis to bone is a common occurrence among epithelial tumors, with a high incidence rate in the Western world. As a result, bone lesions are a significant burden on the healthcare system, with a high morbidity index. These injuries are often symptomatic and can lead to functional limitations, which in turn cause reduced mobility in patients. Additionally, they can lead to secondary complications such as pathological fractures, spinal cord compression, hypercalcemia, or bone marrow suppression. The treatment of bone metastases requires collaboration between multiple healthcare professionals, including oncologists, orthopedists, neurosurgeons, physiatrists, and radiotherapists. The primary objective of this study is to evaluate the correlation between two methods used to assess local control. Specifically, the study aims to determine if a reduction in the volume of bone lesions corresponds to better symptomatic control in the clinical management of patients, and vice versa. To achieve this objective, the study evaluates morphological criteria by comparing pre- and post-radiotherapy treatment imaging using MRI and RECIST 1.1 criteria. MRI without contrast is the preferred diagnostic imaging method, due to its excellent tolerance by patients, the absence of exposure to ionizing radiation, and the avoidance of paramagnetic contrast media side effects. This imaging modality allows for accurate assessment of bone lesions. One of the secondary objectives of this study is to identify potentially useful parameters that can distinguish patients into two classes: “good” and “poor” responders to treatment, as reported by previous studies in the literature. These parameters can be evaluated from the imaging examinations by analyzing morphological changes and radiomic features on different sequences, such as T1, STIR (short tau inversion recovery), and DWI-MRI (diffusion-weighted).

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العلاقة: Medical Imaging and Theranostics; https://dx.doi.org/10.3390/diagnostics13142334Test

الإتاحة: https://doi.org/10.3390/diagnostics13142334Test

المؤلفون: Aurora Santin, Beatrice Spedicati, Anna Morgan, Stefania Lenarduzzi, Paola Tesolin, Giuseppe Giovanni Nardone, Daniela Mazzà, Giovanni Di Lorenzo, Federico Romano, Francesca Buonomo, Alessandro Mangogna, Maria Pina Concas, Gabriella Zito, Giuseppe Ricci, Giorgia Girotto

المصدر: Biomedicines; Volume 11; Issue 8; Pages: 2122

مصطلحات موضوعية: endometriosis, whole-exome sequencing, rare variants, candidate genes, deep clinical evaluation, genotype–phenotype correlations

الوصف: Endometriosis (EM) is a common multifactorial gynaecological disorder. Although Genome-Wide Association Studies have largely been employed, the current knowledge of the genetic mechanisms underlying EM is far from complete, and other approaches are needed. To this purpose, whole-exome sequencing (WES) was performed on a deeply characterised cohort of 80 EM patients aimed at the identification of rare and damaging variants within 46 EM-associated genes and novel candidates. WES analysis detected 63 rare, predicted, and damaging heterozygous variants within 24 genes in 63% of the EM patients. In particular, (1) a total of 43% of patients carried variants within 13 recurrent genes (FCRL3, LAMA5, SYNE1, SYNE2, GREB1, MAP3K4, C3, MMP3, MMP9, TYK2, VEGFA, VEZT, RHOJ); (2) a total of 8.8% carried private variants within eight genes (KAZN, IL18, WT1, CYP19A1, IL1A, IL2RB, LILRB2, ZNF366); (3) a total of 24% carried variants within three novel candidates (ABCA13, NEB, CSMD1). Finally, to deepen the polygenic architecture of EM, a comprehensive evaluation of the analysed genes was performed, revealing a higher burden (p < 0.05) of genes harbouring rare and damaging variants in the EM patients than in the controls. These results highlight new insights into EM genetics, allowing for the definition of novel genotype–phenotype correlations, thereby contributing, in a long-term perspective, to the development of personalised care for EM patients.

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العلاقة: Molecular and Translational Medicine; https://dx.doi.org/10.3390/biomedicines11082122Test

الإتاحة: https://doi.org/10.3390/biomedicines11082122Test

المؤلفون: Giuseppe Giannini, Irene Ragusa, Giulia Nerina Nardone, Sara Soldi, Marina Elli, Piera Valenti, Luigi Rosa

المصدر: Gels; Volume 9; Issue 8; Pages: 607

مصطلحات موضوعية: Tau-Marin, mucoadhesive gel, oral formulation, probiotics, periodontitis, periodontal diseases, slow delivery

الوصف: An innovative and stable probiotic-containing mucoadhesive gel (AL0020), integrated with botanical extracts, has been developed to rebalance the dysbiosis associated with periodontal diseases. Tau-Marin gel, prepared with anhydrous ingredients to prevent the replication of bacteria and ensure good stability over time, was tested against some pathogenic bacteria, belonging to the so-called “red complex”, recognized as the most important pathogens in plaque specimens, adherent to the epithelial lining of periodontal pockets. This lipogel was tested in vitro, in a physiological solution (PS) and in a simulated saliva (SS), for up to 8 h, to monitor its ability to release probiotics over time. Probiotics were enumerated through two different techniques, Lacto-Counter Assay (LCA) and Colony Forming Unit (CFU). A detailed physico-chemical profile of AL0020 and its in vitro efficacy in protecting activity against pathogenic bacteria as well as soothing or irritative effect on gingival epithelium were reported. Moreover, a clinical-dermatological trial on 20 volunteers using the product once a day for 30 days was also performed, where the efficacy of the gel in the control of gum disorders was observed.

وصف الملف: application/pdf

العلاقة: Gel Applications; https://dx.doi.org/10.3390/gels9080607Test

الإتاحة: https://doi.org/10.3390/gels9080607Test

المؤلفون: Paola Nardone, Angela Spinelli, Marta Buoncristiano, Silvia Andreozzi, Mauro Bucciarelli, Marco Giustini, Silvia Ciardullo, on behalf of the EPaS-ISS Group on behalf of the EPaS-ISS Group

المصدر: Nutrients; Volume 15; Issue 15; Pages: 3326

مصطلحات موضوعية: children, family, COVID-19 pandemic, food consumption, eating behaviours

جغرافية الموضوع: agris

الوصف: The aim of the EPaS-ISS study was to describe the changes in food consumption and eating behaviours of children (mainly aged 8–9 years) and their families between the pre-COVID-19 period (before February/March 2020) and the COVID-19 period (from February/March 2020 to April 2022). A web questionnaire completed by parents was used to collect data. The sociodemographic characteristics of the children and their parents were also explored through the web questionnaire. Seventeen regions out of nineteen and the two autonomous provinces (PA) of Italy participated in the study. The survey was completed for 4863 children (47.9% females). The study showed that only small changes in children’s food consumption happened between the pre-COVID-19 period and the COVID-19 period; in particular, about 25% of parents reported an increase in savoury snacks and sweet food. A decrease in fruit and vegetable (about 8%) and fish (14%) consumption was also found. However, the changes seem to have mainly affected children from most disadvantaged families. The results also indicate positive changes during the COVID-19 pandemic in some families’ eating behaviours, such as eating more home-cooked meals (42%) and family meals (39%), as well as cooking more with children (42%).

وصف الملف: application/pdf

العلاقة: Nutrition Methodology & Assessment; https://dx.doi.org/10.3390/nu15153326Test

الإتاحة: https://doi.org/10.3390/nu15153326Test

المؤلفون: Alberta Lucchese, Dario Di Stasio, Simona De Stefano, Michele Nardone, Francesco Carinci

المصدر: Journal of Clinical Medicine; Volume 12; Issue 12; Pages: 3874

مصطلحات موضوعية: celiac disease, gluten, oral manifestations

الوصف: Background: Celiac disease (CD) is a chronic immune-mediated gluten-sensitive enteropathy, affecting about 1% of the population. The most common symptoms include diarrhea, abdominal pain, weight loss, and malabsorption. Extra-intestinal symptoms include oral manifestations. This systematic review aims to catalog and characterize oral manifestations in patients with CD. Methods: a systematic literature review among different search engines using PICOS criteria has been performed. The studies included used the following criteria: tissues and anatomical structures of the oral cavity in humans, published in English and available in full text. Review articles and papers published before 1990 were excluded. Results: 209 articles were identified in the initial search. In the end, 33 articles met the selection criteria. The information extracted from the articles was classified based on the type of oral manifestation. Recurrent aphthous stomatitis (34.6%), atrophic glossitis and geographic tongue (15.26%), enamel defects (42.47%), delayed dental eruption (47.34%), xerostomia (38.05%), glossodynia (14.38%), and other manifestations including cheilitis, fissured tongue, periodontal diseases, and oral lichen planus were found in the celiac subjects of the studies analyzed. The quality of articles on the topic should be improved; however, oral manifestations in CD patients are widely described in the literature and could help diagnose celiac disease.

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العلاقة: Gastroenterology & Hepatopancreatobiliary Medicine; https://dx.doi.org/10.3390/jcm12123874Test

الإتاحة: https://doi.org/10.3390/jcm12123874Test

المؤلفون: Giovanni Battista Rossi, Gabriele Nardone, Giulio Settanta, Marco Picone, Marta Berardengo, Francesco Crenna

المصدر: Sensors; Volume 23; Issue 12; Pages: 5371

مصطلحات موضوعية: sea waves, wave buoys, directional spectrum, directional spreading function

الوصف: Technological development in terms of the power requirement for data acquisition and processing opens new perspectives in the field of environmental monitoring. Near real-time data flow about the sea condition and a possible direct interface with applications and services devoted to marine weather networks would have a significant impact on several aspects, such as, for example, safety and efficiency. In this scenario, the needs of buoy networks have been analyzed, and the estimation of directional wave spectra from buoys’ data has been deeply investigated. Two methods have been implemented, namely the truncated Fourier series and the weighted truncated Fourier series, and they have been tested by both simulated and real experimental data, representative of typical Mediterranean Sea conditions. From simulation, the second method proved to be more efficient. From the application to real case studies, it emerged that it works effectively in real conditions, as confirmed by parallel meteorological observations. The estimation of the main propagation direction was possible with a small uncertainty of a few degrees, yet the method exhibits a limited directional resolution, which suggests the need for undertaking further studies, briefly addressed in the conclusions.

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العلاقة: Remote Sensors; https://dx.doi.org/10.3390/s23125371Test

الإتاحة: https://doi.org/10.3390/s23125371Test

المؤلفون: Giacomo Lazzeri, Silvia Ciardullo, Angela Spinelli, Daniela Pierannunzio, Anna Dzielska, Colette Kelly, Einar B. Thorsteinsson, Gentiana Qirjako, Anouk Geraets, Kristiina Ojala, Manon Rouche, Paola Nardone

المصدر: Nutrients; Volume 15; Issue 11; Pages: 2453

مصطلحات موضوعية: adolescents, breakfast, HBSC, daily breakfast consumption, family affluence, family structure, cross-time data, cross-national data, SES, trends, Europe

جغرافية الموضوع: agris

الوصف: Breakfast is often considered the most important meal of the day and can benefit adolescent health in several ways. The aims of the present study were (1) to identify adolescents’ socio-demographic (sex, family affluence and family structure) determinants of daily breakfast consumption (DBC) and (2) to describe trends in DBC among adolescents across 23 countries. Cross-sectional surveys of nationally representative samples of adolescents (aged 11, 13, and 15 years) (n = 589,737) participating in the Health Behaviour in School-aged Children (HBSC) survey from 2002 to 2018 were used. Multilevel logistic regression analyses modeled DBC over time, adjusted for family affluence, family structure and year of survey. Four countries showed an increased trend in DBC (the Netherlands, Macedonia, Slovenia, and England). A significant decrease in DBC was observed in 15 countries (Belgium-Fr, France, Germany, Croatia, Portugal, Spain, Hungary, Poland, Russian Federation, Ukraine, Denmark, Finland, Latvia, Lithuania and Sweden). In 4 countries no significant change was observed (Czech Republic, Scotland, Ireland and Norway). In most of the countries (n = 19), DBC was higher among the adolescents from high-affluence homes. In all the countries analysed, the adolescents living in two-parent households report higher DBC use than those in single-parent households. More than half of the countries showed a decrease in DBC. There is a need to implement key interventions by developing different strategies (education, incorporating educational curriculum and counselling programmes) to increase DBC. Comparing DBC patterns across HBSC countries is important for understanding regional and global trends, monitoring strategies, and developing health promotion programmes.

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العلاقة: Nutrition Methodology & Assessment; https://dx.doi.org/10.3390/nu15112453Test

الإتاحة: https://doi.org/10.3390/nu15112453Test

المؤلفون: Amy Riddell, Aislinn Cook, Nathalie Khavessian, Sally Ellis, Davide Bilardi, Erika Correia, Tomislav Kostyanev, Alessandra Nardone, Neal Russell, Tuba Vilken, Wolfgang Stohr, Bethou Adhisivam, Iana Rosa Alves de Moraes, Nawshad Uddin Ahmed, Adrie Bekker, Eitan Naaman Berezin, Suppawat Boonkasidecha, Cristina G. Carvalheiro, Prachi Chauhan, Sara Chiurchiù, Elisavet Chorafa, Angela Dramowski, Madhusudhan DS, Jinxing Feng, Shengnan Jia, Yuan Kong, Mary Kyohere, Angeliki Kontou, Sorasak Lochindarat, Maia De Luca, Aripfani Mphaphuli, Marisa M. Mussi-Pinhata, Sheila Murunga, Firdose Lambey Nakwa, Sushma Nangia, Erinah Nassolo, Ngoc Thi Bin Hoang, Christina W. Obiero, Linus Olson, Wang Ping, Nishad Plakkal, Priyanka Prasad, Kanchana Preedisripipat, Sheikh Wasik Rahman, Tiffany Seef, Pra-ornsuda Sukrakanchana, Reenu Thomas, Zhang Yu, Qiaoru Zhang, A. Sarah Walker, Julia Bielicki, Paul T. Heath, Michael Sharland, Tatiana Munera-Huertas

المصدر: Antibiotics; Volume 12; Issue 5; Pages: 923

مصطلحات موضوعية: neonatal sepsis, antimicrobial resistance, antibiotic treatment, LMIC, global collaboration, empiric antibiotics, clinical trials

الوصف: Neonatal sepsis is a significant cause of mortality and morbidity in low- and middle-income countries. To deliver high-quality data studies and inform future trials, it is crucial to understand the challenges encountered when managing global multi-centre research studies and to identify solutions that can feasibly be implemented in these settings. This paper provides an overview of the complexities faced by diverse research teams in different countries and regions, together with actions implemented to achieve pragmatic study management of a large multi-centre observational study of neonatal sepsis. We discuss specific considerations for enrolling sites with different approval processes and varied research experience, structures, and training. Implementing a flexible recruitment strategy and providing ongoing training were necessary to overcome these challenges. We emphasize the attention that must be given to designing the database and monitoring plans. Extensive data collection tools, complex databases, tight timelines, and stringent monitoring arrangements can be problematic and might put the study at risk. Finally, we discuss the complexities added when collecting and shipping isolates and the importance of having a robust central management team and interdisciplinary collaborators able to adapt easily and make swift decisions to deliver the study on time and to target. With pragmatic approaches, appropriate training, and good communication, these challenges can be overcome to deliver high-quality data from a complex study in challenging settings through a collaborative research network.

وصف الملف: application/pdf

العلاقة: Antibiotics Use and Antimicrobial Stewardship; https://dx.doi.org/10.3390/antibiotics12050923Test

الإتاحة: https://doi.org/10.3390/antibiotics12050923Test