التفاصيل البيبلوغرافية
| العنوان: |
Effects of T-Cell Depletion on Allogeneic Hematopoietic Stem Cell Transplantation Outcomes in AML Patients |
| المؤلفون: |
Gabriela Hobbs, Miguel-Angel Perales |
| المصدر: |
Journal of Clinical Medicine; Volume 4; Issue 3; Pages: 488-503 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2015 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
AML, CD34+ selection, T-cell depletion, graft- versus -host disease, hematopoietic stem cell transplantation |
| الوصف: |
Graft versus host disease (GVHD) remains one of the leading causes of morbidity and mortality associated with conventional allogeneic hematopoietic stem cell transplantation (HCT). The use of T-cell depletion significantly reduces this complication. Recent prospective and retrospective data suggest that, in patients with AML in first complete remission, CD34+ selected grafts afford overall and relapse-free survival comparable to those observed in recipients of conventional grafts, while significantly decreasing GVHD. In addition, CD34+ selected grafts allow older patients, and those with medical comorbidities or with only HLA-mismatched donors to successfully undergo transplantation. Prospective data are needed to further define which groups of patients with AML are most likely to benefit from CD34+ selected grafts. Here we review the history of T-cell depletion in AML, and techniques used. We then summarize the contemporary literature using CD34+ selection in recipients of matched or partially mismatched donors (7/8 or 8/8 HLA-matched), and provide a summary of the risks and benefits of using T-cell depletion. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Hematology; https://dx.doi.org/10.3390/jcm4030488Test |
| DOI: |
10.3390/jcm4030488 |
| الإتاحة: |
https://doi.org/10.3390/jcm4030488Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.393B3FED |
| قاعدة البيانات: |
BASE |
