التفاصيل البيبلوغرافية
| العنوان: |
Genistein during Development Alters Differentially the Expression of POMC in Male and Female Rats |
| المؤلفون: |
Jose Manuel Fernandez-Garcia, Beatriz Carrillo, Patricia Tezanos, Paloma Collado, Helena Pinos |
| المصدر: |
Metabolites; Volume 11; Issue 5; Pages: 293 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2021 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
genistein, proopiomelanocortin, arcuate nucleus, sex differences, rats |
| الوصف: |
Phytoestrogens are considered beneficial for health, but some studies have shown that they may cause adverse effects. This study investigated the effects of genistein administration during the second week of life on energy metabolism and on the circuits regulating food intake. Two different genistein doses, 10 or 50 µg/g, were administered to male and female rats from postnatal day (P) 6 to P13. Physiological parameters, such as body weight and caloric intake, were then analyzed at P90. Moreover, proopiomelanocortin (POMC) expression in the arcuate nucleus (Arc) and orexin expression in the dorsomedial hypothalamus (DMH), perifornical area (PF) and lateral hypothalamus (LH) were studied. Our results showed a delay in the emergence of sex differences in the body weight in the groups with higher genistein doses. Furthermore, a significant decrease in the number of POMC-immunoreactive (POMC-ir) cells in the Arc in the two groups of females treated with genistein was observed. In contrast, no alteration in orexin expression was detected in any of the structures analyzed in either males or females. In conclusion, genistein can modulate estradiol’s programming actions on the hypothalamic feeding circuits differentially in male and female rats during development. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Endocrinology and Clinical Metabolic Research; https://dx.doi.org/10.3390/metabo11050293Test |
| DOI: |
10.3390/metabo11050293 |
| الإتاحة: |
https://doi.org/10.3390/metabo11050293Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.7009D3C7 |
| قاعدة البيانات: |
BASE |
