التفاصيل البيبلوغرافية
| العنوان: |
Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways |
| المؤلفون: |
Xi-Lin Lu, Zhong-Liang Xu, Xiao-Li Yao, Feng-Juan Su, Cheng-Hui Ye, Jing Li, Yong-Cheng Lin, Guang-Lei Wang, Jin-Sheng Zeng, Ru-Xun Huang, Jing-Song Ou, Hong-Shuo Sun, Li-Ping Wang, Ji-Yan Pang, Zhong Pei |
| المصدر: |
Marine Drugs; Volume 10; Issue 6; Pages: 1307-1320 |
| بيانات النشر: |
Molecular Diversity Preservation International |
| سنة النشر: |
2012 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
angiogenesis, marine cyclotripeptide, zebrafish, endothelial nitric oxide synthase, xyloallenoide A |
| جغرافية الموضوع: |
agris |
| الوصف: |
Cyclotripeptide X-13 is a core of novel marine compound xyloallenoide A isolated from mangrove fungus Xylaria sp. (no. 2508). We found that X-13 dose-dependently induced angiogenesis in zebrafish embryos and in human endothelial cells, which was accompanied by increased phosphorylation of eNOS and Akt and NO release. Inhibition of PI3K/Akt/eNOS by LY294002 or l-NAME suppressed X-13-induced angiogenesis. The present work demonstrates that X-13 promotes angiogenesis via PI3K/Akt/eNOS pathways. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
https://dx.doi.org/10.3390/md10061307Test |
| DOI: |
10.3390/md10061307 |
| الإتاحة: |
https://doi.org/10.3390/md10061307Test |
| حقوق: |
https://creativecommons.org/licenses/by/3.0Test/ |
| رقم الانضمام: |
edsbas.FD995A3D |
| قاعدة البيانات: |
BASE |
