التفاصيل البيبلوغرافية
| العنوان: |
Delivery of Nitric Oxide in the Cardiovascular System: Implications for Clinical Diagnosis and Therapy |
| المؤلفون: |
Tianxiang Ma, Zhexi Zhang, Yu Chen, Haoran Su, Xiaoyan Deng, Xiao Liu, Yubo Fan |
| المصدر: |
International Journal of Molecular Sciences; Volume 22; Issue 22; Pages: 12166 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2021 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
nitric oxide delivery, computational modeling, flow-mediated dilation, NO release platform, inhaled NO therapy, stem cell therapy |
| جغرافية الموضوع: |
agris |
| الوصف: |
Nitric oxide (NO) is a key molecule in cardiovascular homeostasis and its abnormal delivery is highly associated with the occurrence and development of cardiovascular disease (CVD). The assessment and manipulation of NO delivery is crucial to the diagnosis and therapy of CVD, such as endothelial dysfunction, atherosclerotic progression, pulmonary hypertension, and cardiovascular manifestations of coronavirus (COVID-19). However, due to the low concentration and fast reaction characteristics of NO in the cardiovascular system, clinical applications centered on NO delivery are challenging. In this tutorial review, we first summarized the methods to estimate the in vivo NO delivery process, based on computational modeling and flow-mediated dilation, to assess endothelial function and vulnerability of atherosclerotic plaque. Then, emerging bioimaging technologies that have the potential to experimentally measure arterial NO concentration were discussed, including Raman spectroscopy and electrochemical sensors. In addition to diagnostic methods, therapies aimed at controlling NO delivery to regulate CVD were reviewed, including the NO release platform to treat endothelial dysfunction and atherosclerosis and inhaled NO therapy to treat pulmonary hypertension and COVID-19. Two potential methods to improve the effectiveness of existing NO therapy were also discussed, including the combination of NO release platform and computational modeling, and stem cell therapy, which currently remains at the laboratory stage but has clinical potential for the treatment of CVD. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
https://dx.doi.org/10.3390/ijms222212166Test |
| DOI: |
10.3390/ijms222212166 |
| الإتاحة: |
https://doi.org/10.3390/ijms222212166Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.D1D0BF3C |
| قاعدة البيانات: |
BASE |
