التفاصيل البيبلوغرافية
| العنوان: |
Zytoprotektion mit Amifostin (Ethyol®) in der Chemotherapie: Meta-Analyse zum pharmakokinetischen Interaktionspotential mit Zytostatika |
| المؤلفون: |
Martin Czejka, Johannes Schüller, Heidemarie Kletzl |
| المصدر: |
Scientia Pharmaceutica; Volume 69; Issue 4; Pages: 289-297 |
| بيانات النشر: |
Austrian Pharmaceutical Society |
| سنة النشر: |
2001 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
amifostine, pharmacokinetics, drug interaction, cytostatics |
| الوصف: |
The cytoprotective agent amifostine (AMI) is capable to protect healthy cells (contrary to tumor cells) due to higher activity of alkaline phosphatase at the membrane site of normal cells. In seven clinical trials the influence of AMI on the pharmacokinetics of different cytostatics was investigated. Preadministration of AMI increased Cmax of doxorubicin (+ 44 %, p < 0.06), epirubicin (+ 31 %, P < 0.08), mitomycin C (+ 41 %, p < 0.01) and docetaxel (+ 31 % and + 17 %, not significant). In contrary, the peak concentration of pirarubicin , the tetrahydropyranyl-prodrug of doxorubicin was decreased (- 50 %, P < 0.03), leading to an equal higher concentrationof doxorubicin in the blood . In accordance to the peak concentrations, the AUC'ast was increased by chemoprotection: doxorubicin + 53 % (p < 0.01) and epirubicin + 23 % (not significant), docetaxel + 25 % and + 31 % (not significant). AUC'ast of mitomycin C and paclitaxel seemed to be unaffected by preadministered AMI. A particular inhibition of the protein binding by AMI has been identified as one reason for higher serum concentrations of anthracycline drugs. After cytoprotection, a possible increase of the cytostatic's Serum concentrations should be taken into account for optimal dosage schedules. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
https://dx.doi.org/10.3797/scipharm.aut-01-200Test |
| DOI: |
10.3797/scipharm.aut-01-200 |
| الإتاحة: |
https://doi.org/10.3797/scipharm.aut-01-200Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.A2FA8F64 |
| قاعدة البيانات: |
BASE |
