التفاصيل البيبلوغرافية
| العنوان: |
Effects of Creatine Supplementation on the Myostatin Pathway and Myosin Heavy Chain Isoforms in Different Skeletal Muscles of Resistance-Trained Rats |
| المؤلفون: |
Marianna Rabelo de Carvalho, Ellen Fernandes Duarte, Maria Lua Marques Mendonça, Camila Souza de Morais, Gabriel Elias Ota, Jair José Gaspar-Junior, Wander Fernando de Oliveira Filiú, Felipe Cesar Damatto, Marina Politi Okoshi, Katashi Okoshi, Rodrigo Juliano Oliveira, Paula Felippe Martinez, Silvio Assis de Oliveira-Junior |
| المصدر: |
Nutrients; Volume 15; Issue 9; Pages: 2224 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2023 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
strength training, myostatin, muscle anabolism, creatine, muscle fibers |
| جغرافية الموضوع: |
agris |
| الوصف: |
Creatine has been used to maximize resistance training effects on skeletal muscles, including muscle hypertrophy and fiber type changes. This study aimed to evaluate the impact of creatine supplementation on the myostatin pathway and myosin heavy chain (MyHC) isoforms in the slow- and fast-twitch muscles of resistance-trained rats. Twenty-eight male Wistar rats were divided into four groups: a sedentary control (Cc), sedentary creatine supplementation (Cr), resistance training (Tc), and resistance training combined with creatine supplementation (Tcr). Cc and Tc received standard commercial chow; Cr and Tcr received a 2% creatine-supplemented diet. Tc and Tcr performed a resistance training protocol on a ladder for 12 weeks. Morphology, MyHC isoforms, myostatin, follistatin, and ActRIIB protein expressions were analyzed in soleus and white gastrocnemius portion samples. The results were analyzed using two-way ANOVA and Tukey’s test. Tc and Tcr exhibited higher performance than their control counterparts. Resistance training increased the ratio between muscle and body weight, the cross-sectional area, as well as the interstitial collagen fraction. Resistance training alone increased MyHC IIx and follistatin while reducing myostatin (p < 0.001) and ActRIIB (p = 0.040) expressions in the gastrocnemius. Resistance training induced skeletal muscle hypertrophy and interstitial remodeling, which are more evident in the gastrocnemius muscle. The effects were not impacted by creatine supplementation. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Sports Nutrition; https://dx.doi.org/10.3390/nu15092224Test |
| DOI: |
10.3390/nu15092224 |
| الإتاحة: |
https://doi.org/10.3390/nu15092224Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.6CE61E9B |
| قاعدة البيانات: |
BASE |
