التفاصيل البيبلوغرافية
| العنوان: |
Alteration of the Functional Connectivity of the Cortical Areas Characterized by the Presence of Von Economo Neurons in Schizophrenia, a Pilot Study |
| المؤلفون: |
Claudio Brasso, Mario Stanziano, Francesca Marina Bosco, Rosalba Morese, Maria Consuelo Valentini, Alessandro Vercelli, Paola Rocca |
| المصدر: |
Journal of Clinical Medicine; Volume 12; Issue 4; Pages: 1377 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2023 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
von Economo neurons, VENs, fMRI, schizophrenia, resting-state functional connectivity, salience network, negative symptoms, functioning, anterior insula, ventral tegmental area |
| الوصف: |
Von Economo neurons (VENs) are rod, stick, or corkscrew cells mostly located in layer V of the frontoinsular and anterior cingulate cortices. VENs are projection neurons related to human-like social cognitive abilities. Post-mortem histological studies found VEN alterations in several neuropsychiatric disorders, including schizophrenia (SZ). This pilot study aimed to evaluate the role of VEN-containing areas in shaping patterns of resting-state brain activation in patients with SZ (n = 20) compared to healthy controls (HCs; n = 20). We performed a functional connectivity analysis seeded in the cortical areas with the highest density of VENs followed by fuzzy clustering. The alterations found in the SZ group were correlated with psychopathological, cognitive, and functioning variables. We found a frontotemporal network that was shared by four clusters overlapping with the salience, superior-frontal, orbitofrontal, and central executive networks. Differences between the HC and SZ groups emerged only in the salience network. The functional connectivity of the right anterior insula and ventral tegmental area within this network were negatively correlated with experiential negative symptoms and positively correlated with functioning. This study provides some evidence to show that in vivo, VEN-enriched cortical areas are associated with an altered resting-state brain activity in people with SZ. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Mental Health; https://dx.doi.org/10.3390/jcm12041377Test |
| DOI: |
10.3390/jcm12041377 |
| الإتاحة: |
https://doi.org/10.3390/jcm12041377Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.73E771E7 |
| قاعدة البيانات: |
BASE |
