التفاصيل البيبلوغرافية
| العنوان: |
Non-Steroidal Anti-Inflammatory Drugs in the Carcinogenesis of the Gastrointestinal Tract |
| المؤلفون: |
Debora Compare, Olga Nardone, Gerardo Nardone |
| المصدر: |
Pharmaceuticals; Volume 3; Issue 8; Pages: 2495-2516 |
| بيانات النشر: |
Molecular Diversity Preservation International |
| سنة النشر: |
2010 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
cyclooxygenase-2, non-steroidal anti-inflammatory drugs, esophageal cancer, gastric cancer, colorectal cancer |
| الوصف: |
It is estimated that underlying infections and inflammatory responses are linked to 15–20% of all deaths from cancer worldwide. Inflammation is a physiologic process in response to tissue damage resulting from microbial pathogen infection, chemical irritation, and/or wounding. Tissues injured throughout the recruitment of inflammatory cells such as macrophages and neutrophils, generate a great amount of growth factors, cytokines, and reactive oxygen and nitrogen species that may cause DNA damage that in turn predisposes to the transformation from chronic inflammation to neoplasia. Cyclooxygenase (COX), playing a key role in cell homeostasis, angiogenesis and tumourigenesis, may represent the link between inflammation and cancer. Currently COX is becoming a pharmacological target for cancer prevention and treatment.It is estimated that underlying infections and inflammatory responses are linked to 15–20% of all deaths from cancer worldwide. Inflammation is a physiologic process in response to tissue damage resulting from microbial pathogen infection, chemical irritation, and/or wounding. Tissues injured throughout the recruitment of inflammatory cells such as macrophages and neutrophils, generate a great amount of growth factors, cytokines, and reactive oxygen and nitrogen species that may cause DNA damage that in turn predisposes to the transformation from chronic inflammation to neoplasia. Cyclooxygenase (COX), playing a key role in cell homeostasis, angiogenesis and tumourigenesis, may represent the link between inflammation and cancer. Currently COX is becoming a pharmacological target for cancer prevention and treatment. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
https://dx.doi.org/10.3390/ph3082495Test |
| DOI: |
10.3390/ph3082495 |
| الإتاحة: |
https://doi.org/10.3390/ph3082495Test |
| حقوق: |
https://creativecommons.org/licenses/by/3.0Test/ |
| رقم الانضمام: |
edsbas.9BCA6488 |
| قاعدة البيانات: |
BASE |
