دورية أكاديمية
The effect of connective tissue graft or a collagen matrix on epithelial differentiation around teeth and implants : a preclinical study in minipigs
| العنوان: | The effect of connective tissue graft or a collagen matrix on epithelial differentiation around teeth and implants : a preclinical study in minipigs |
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| المؤلفون: | Stähli, Alexandra, Párkányi, László, Aroca, Sofia, Stavropoulos, Andreas, Schwarz, Frank, Sculean, Anton, Bosshardt, Dieter D |
| بيانات النشر: | Malmö universitet, Odontologiska fakulteten (OD) Department of Periodontology, School of Dental Medicine, University of Bern, Freiburgstrasse 7, 3010, Bern, Switzerland Department of Periodontology, Faculty of Dentistry, University of Szeged, 6720 Tisza Lajos Körút 64, Szeged, Hungary Department of Oral Surgery and Implantology, Goethe University, Theodor-Stern-Kai 7, 60596, Frankfurt, Germany Department of Periodontology, School of Dental Medicine, University of Bern, Freiburgstrasse 7, 3010, Bern, Switzerland; Robert K. Schenk Laboratory of Oral Histology, School of Dental Medicine, University of Bern, Freiburgstrasse 3, 3010, Bern, Switzerland |
| سنة النشر: | 2023 |
| المجموعة: | Malmö University Electronic Publishing (MUEP) |
| مصطلحات موضوعية: | Connective tissue graft, Dental implants, Keratinization, Minipig, Single tooth, Dentistry, Odontologi |
| الوصف: | OBJECTIVES: This study aimed to histologically evaluate the healing at 8 weeks after coronally advanced flap (CAF) with either a superficial (SCTG) or deep palatal connective tissue graft (DCTG), or a collagen matrix (CM) to cover recession defects at teeth and implants. MATERIAL AND METHODS: One mandibular side of 6 miniature pigs received each 3 titanium implants 12 weeks after extraction. Eight weeks later, recession defects were created around implants and contralateral premolars and 4 weeks later randomly subjected to CAF + SCTG, CAF + DCTG, or CAF + CM. After 8 weeks, block biopsies were histologically analyzed. RESULTS: For the primary outcome, i.e., keratinization of the epithelium, all teeth and implants exhibited a keratinized epithelium with no histological differences among them also not in terms of statistically significant differences in length (SCTG 0.86 ± 0.92 mm, DCTG 1.13 ± 0.62 mm, and Cm, 1.44 ± 0.76 mm). Pocket formation was histologically seen at all teeth, around most implants with SCTG and DCTG, however not in the CM implant group. The connective tissue grafts showed hardly signs of degradation, whereas the CM was partly degraded and integrated in connective tissue. The mean gain in gingival height was similar in all experimental groups (SCTG 3.89 ± 0.80 mm, DCTG 4.01 ± 1.40 mm, CM 4.21 ± 0.64 mm). Statistically significant differences were found in the height of the junctional epithelium between the control teeth and the connective tissue groups (p = 0.009 and 0.044). CONCLUSIONS: In this animal model, the use of either a superficial or deep connective tissue graft or a collagen membrane did not seem to have any impact on the epithelial keratinization around both teeth and implants. All procedures (CAF + SCTG/DCTG/CM) resulted in a long JE that was even longer at implants. CLINICAL RELEVANCE: Deep/superficial palatal connective tissue graft yielded similar keratinization around teeth/implants. Given the absence of pocket formation and inflammatory processes at implants when using a CM, ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Clinical Oral Investigations, 1432-6981, 2023, 27:8, s. 4553-4566; orcid:0000-0001-8161-3754; http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-61378Test; PMID 37300738; ISI:001004055300002; Scopus 2-s2.0-85161405691 |
| DOI: | 10.1007/s00784-023-05080-5 |
| الإتاحة: | https://doi.org/10.1007/s00784-023-05080-5Test http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-61378Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.EF14A032 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00784-023-05080-5 |
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