دورية أكاديمية
Calorie restriction improves lipid-related emerging cardiometabolic risk factors in healthy adults without obesity: Distinct influences of BMI and sex from CALERIE™ a multicentre, phase 2, randomised controlled trial
| العنوان: | Calorie restriction improves lipid-related emerging cardiometabolic risk factors in healthy adults without obesity: Distinct influences of BMI and sex from CALERIE™ a multicentre, phase 2, randomised controlled trial |
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| المؤلفون: | Huffman, Kim M, Parker, Daniel C, Bhapkar, Manjushri, Racette, Susan B, Martin, Corby K, Redman, Leanne M, Das, Sai Krupa, Connelly, Margery A, Pieper, Carl F, Orenduff, Melissa, Ross, Leanna M, Ramaker, Megan E, Dorling, James L, Rosen, Clifford J, Shalaurova, Irina, Otvos, James D, Kraus, Virginia B, Kraus, William E |
| المصدر: | Maine Medical Center |
| بيانات النشر: | MaineHealth Knowledge Connection |
| سنة النشر: | 2022 |
| المجموعة: | MaineHealth Knowledge Connection |
| مصطلحات موضوعية: | Cardiovascular disease, Insulin resistance, Nuclear magnetic resonance spectroscopy, Type 2 diabetes risk |
| الوصف: | BACKGROUND: For many cardiovascular risk factors there is no lower limit to which further reduction will result in decreased disease risk; this includes values within ranges considered normal for healthy adults. This seems to be true for new emerging metabolic risk factors identified by innovative technological advances. Further, there seems to be ever evolving evidence of differential responses to lifestyle interventions by sex and body compositions in the normal range. In this secondary analysis, we had the opportunity to test these principles for newly identified molecular biomarkers of cardiometabolic risk in a young (21-50 years), normal weight healthy population undergoing calorie restriction for two years. METHODS: The Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE™) was a 24-month, multicenter, randomized controlled trial (May 2007-November 2012) in healthy, adults without obesity to evaluate the potential for calorie restriction (CR) to promote anti-aging adaptations, including those associated with disease risk. 218 participants (age 37.9 ± 7.2 years and body mass index (BMI) 25.1 ± 1.7 kg/m, mean±SD) were randomized 2:1 to 24 months of CR (prescribed as 25% reduction from baseline calorie intake) versus ad libitum (AL). Fasting plasma from baseline, 12, and 24 months was used for assessments of lipoproteins, metabolites, and inflammatory markers using nuclear magnetic resonance spectroscopy. FINDINGS: Averaging 11.9% CR, the CR group had reductions at 12 and 24 months in the cardiovascular disease risk markers, apolipoprotein B and GlycA, and risks for insulin resistance and type 2 diabetes-Lipoprotein Insulin Resistance Index and Diabetes Risk Index (all ≤0.0009). Insulin resistance and diabetes risk improvements resulted from CR-induced alterations in lipoproteins, specifically reductions in triglyceride-rich lipoprotein particles and low-density lipoprotein particles, a shift to larger high-density lipoprotein particles (more effective cholesterol transporters), ... |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://knowledgeconnection.mainehealth.org/mmc/3531Test; https://pubmed.ncbi.nlm.nih.gov/35028547Test/ |
| الإتاحة: | https://knowledgeconnection.mainehealth.org/mmc/3531Test https://pubmed.ncbi.nlm.nih.gov/35028547Test/ |
| رقم الانضمام: | edsbas.9D5C3C2C |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |