دورية أكاديمية
Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron.
| العنوان: | Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron. |
|---|---|
| المؤلفون: | Lindström, Nils O, Lawrence, Melanie L, Burn, Sally F, Johansson, Jeanette A, Bakker, Elvira R M, Ridgway, Rachel A, Chang, C-Hong, Karolak, Michele J, Oxburgh, Leif, Headon, Denis J, Sansom, Owen J, Smits, Ron, Davies, Jamie A, Hohenstein, Peter |
| المصدر: | Maine Medical Center |
| بيانات النشر: | MaineHealth Knowledge Connection |
| سنة النشر: | 2015 |
| المجموعة: | MaineHealth Knowledge Connection |
| مصطلحات موضوعية: | Animals, Body Patterning, Bone Morphogenetic Proteins, Cell Differentiation, Diffusion Chambers, Culture, Embryo, Mammalian, Epithelial Cells, Gene Expression Regulation, Developmental, Mice, Transgenic, Nephrons, Organ Culture Techniques, PTEN Phosphohydrolase, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, RNA, Small Interfering, Receptors, Notch, Signal Transduction, beta Catenin, Medical Cell Biology, Medical Molecular Biology, Nephrology |
| الوصف: | The different segments of the nephron and glomerulus in the kidney balance the processes of water homeostasis, solute recovery, blood filtration, and metabolite excretion. When segment function is disrupted, a range of pathological features are presented. Little is known about nephron patterning during embryogenesis. In this study, we demonstrate that the early nephron is patterned by a gradient in β-catenin activity along the axis of the nephron tubule. By modifying β-catenin activity, we force cells within nephrons to differentiate according to the imposed β-catenin activity level, thereby causing spatial shifts in nephron segments. The β-catenin signalling gradient interacts with the BMP pathway which, through PTEN/PI3K/AKT signalling, antagonises β-catenin activity and promotes segment identities associated with low β-catenin activity. β-catenin activity and PI3K signalling also integrate with Notch signalling to control segmentation: modulating β-catenin activity or PI3K rescues segment identities normally lost by inhibition of Notch. Our data therefore identifies a molecular network for nephron patterning. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://knowledgeconnection.mainehealth.org/mmc/480Test; https://ncbi.nlm.nih.gov/pubmed/25647637Test/ |
| الإتاحة: | https://knowledgeconnection.mainehealth.org/mmc/480Test https://ncbi.nlm.nih.gov/pubmed/25647637Test/ |
| رقم الانضمام: | edsbas.13F3D8AE |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |